{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:15:00Z","timestamp":1783026900764,"version":"3.54.6"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are rare, affecting only a small portion of the general population. In many cases, MPNSTs occur in association with neurofibromatosis Type 1 and at times arise secondary to previous radiation therapy (RT). These tumors can be found essentially anywhere a peripheral nerve is present, but they rarely originate primarily from the spinal nerve or cauda equina and cause leptomeningeal spread. This report describes the treatment course of a 43-year-old man with a history of testicular seminoma treated with RT a decade before, who was found to have a large sacral MPNST. The patient underwent complete sacrectomy for gross-total resection. Despite this effort, he was eventually found to have metastatic lesions throughout the spine and brain, ultimately resulting in acute hydrocephalus and death. Biopsy results of these metastatic lesions proved to be characteristic of his original MPNST. The literature is also reviewed and the diagnostic modalities, management strategies, and prognosis of MPNST are discussed.<\/jats:p>","DOI":"10.3171\/2014.7.spine13802","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T08:25:08Z","timestamp":1414830308000},"page":"719-726","source":"Crossref","is-referenced-by-count":12,"title":["Radiation-induced intradural malignant peripheral nerve sheath tumor of the cauda equina with diffuse leptomeningeal metastasis"],"prefix":"10.3171","volume":"21","author":[{"given":"Darryl","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic H.","family":"Moon","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School and\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Park","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Hervey-Jumper","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"McKeever","sequence":"additional","affiliation":[{"name":"Departments of Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Orringer","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine13802","series-title":"Neurol Sci","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s100720100009","article-title":"Malignant peripheral nerve sheath tumor of the cauda equina","volume":"22","author":"Acharya","year":"2001"},{"key":"b2-spine13802","series-title":"Clin Neuropathol","first-page":"245","article-title":"Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma","volume":"23","author":"Adamson","year":"2004"},{"key":"b3-spine13802","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s11060-005-9086-9","article-title":"A case of intra-dural malignant peripheral nerve sheath tumor in thoracic spine associated with neurofibromatosis type 1","volume":"78","author":"Albayrak","year":"2006"},{"key":"b4-spine13802","series-title":"Eur Urol","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.eururo.2011.05.038","article-title":"EAU guidelines on testicular cancer: 2011 update","volume":"60","author":"Albers","year":"2011"},{"key":"b5-spine13802","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"E506","DOI":"10.1097\/01.brs.0000143168.87295.ca","article-title":"Radiotherapy-induced malignant peripheral nerve sheath tumor of the cauda equina","volume":"29","author":"Amin","year":"2004"},{"key":"b6-spine13802","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1212\/01.WNL.0000078813.05925.2C","article-title":"Malignant peripheral nerve sheath tumor: the clinical spectrum and outcome of treatment","volume":"61","author":"Baehring","year":"2003"},{"key":"b7-spine13802","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3109\/00016926209169572","article-title":"Changes in peripheral nerve tissue after irradiation with high energy protons","volume":"58","author":"Bergstrom","year":"1962"},{"key":"b8-spine13802","series-title":"Front Oncol","first-page":"73","article-title":"Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk","volume":"3","author":"Braunstein","year":"2013"},{"key":"b9-spine13802","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/BF02307414","article-title":"Primary spinal malignant schwannomas: clinical and prognostic remarks","volume":"135","author":"Celli","year":"1995"},{"key":"b10-spine13802","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6","article-title":"Malignant peripheral nerve sheath tumors. 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