{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:22:53Z","timestamp":1762017773296},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\nObject<\/jats:title>\nMeningiomas are benign extraaxial tumors with a slow progression. Some of them, in spite of being benign in nature, may show an aggressive progression pattern. To investigate the behavioral characteristics of meningiomas, researchers have studied matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), interstitial collagens, proteins, vascular endothelial growth factors (VEGF), and tumor necrosis factors.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nIn this study, the authors investigated MMP2<\/jats:italic> and TIMP2<\/jats:italic> gene polymorphisms in formalin-fixed paraffin-embedded tissue samples obtained from meningioma patients who had previously undergone surgery at the authors' institution. In addition, brain invasion, Ki-67 index, and MMP-2 and TIMP-2 expressions were investigated using immunohistochemical methods. MMP2<\/jats:italic> (735C>T, 1575G>A, 1306C>T) and TIMP2<\/jats:italic> (418G>C, 303C>T) gene polymorphisms were investigated from paraffin-embedded tissue sections using the polymerase chain reaction\u2013restriction fragment length polymorphism method.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThere were statistically significant differences between genotype (p = 0.001) and allele frequencies (p = 0.001 and OR 7.4 [95% CI 1.5\u201336.2]) in patient and control groups for MMP2<\/jats:italic> 1306C>T polymorphism. The authors did not find a statistically significant difference for other polymorphisms. GA genotype was found to be more frequent when brain invasion was suspected for MMP2<\/jats:italic> 1575G>A polymorphism (p = 0.006). There was not a statistically significant difference for other MMP2<\/jats:italic> or TIMP2<\/jats:italic> gene polymorphisms.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe authors' results support the importance of MMPs and their tissue inhibitors in meningioma pathogenesis. In future studies, these gene polymorphisms, especially MMP2<\/jats:italic> 1306C>T and 1575G>A, should be investigated for meningioma or brain invasion susceptibility in larger study groups.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.8.jns13515","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T15:24:25Z","timestamp":1411745065000},"page":"1478-1482","source":"Crossref","is-referenced-by-count":10,"title":["Presence of matrix metalloproteinase\u20132 and tissue inhibitor matrix metalloproteinase\u20132 gene polymorphisms and immunohistochemical expressions in intracranial meningiomas"],"prefix":"10.3171","volume":"121","author":[{"given":"\u0130lker","family":"Coven","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge","family":"Ozer","sequence":"additional","affiliation":[{"name":"Medical Genetics, 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