{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:54:12Z","timestamp":1793084052141,"version":"4.5.0"},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Patients with Gorham-Stout disease (GSD), a rare disease of poorly understood etiopathophysiology, suffer from progressive osteolysis. Destruction of bone matrix is caused by lymphatic vessels, which can lead to CSF leakage if parts of bony structures adjacent to CSF spaces are involved. So far, fewer than 200 patients have been reported in the literature; only 4 of these patients presented with CSF leakage. The authors report the case of a 30-year-old man with GSD and CSF leakage due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine. Neurosurgical intervention, including dura repair, was needed. Experimental medical therapy with rapamycin was started, leading to disease control for more than 12 months. Progression of GSD can lead to destruction of the meninges, causing CSF leakage. The authors review 4 other cases reported in the literature and discuss therapeutic options.<\/jats:p>","DOI":"10.3171\/2014.8.spine131064","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T14:01:07Z","timestamp":1413554467000},"page":"956-960","source":"Crossref","is-referenced-by-count":21,"title":["Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine"],"prefix":"10.3171","volume":"21","author":[{"given":"Eric Jose","family":"Suero Molina","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Niederstadt","sequence":"additional","affiliation":[{"name":"Clinical Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Ruland","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital of M\u00fcnster; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Kayser","sequence":"additional","affiliation":[{"name":"Institute of Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Stummer","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ewelt","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine131064","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"E198","DOI":"10.3174\/ajnr.A2413","article-title":"Intraosseous CSF fistula in a patient with Gorham disease resulting in intracranial hypotension","volume":"32","author":"Adler","year":"2011"},{"key":"b2-spine131064","series-title":"Ann Thorac Surg","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0003-4975(00)02417-6","article-title":"Chylothorax complicating Gorham's disease","volume":"72","author":"Chavanis","year":"2001"},{"key":"b3-spine131064","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/MAO.0b013e3181de46c5","article-title":"Gorhamstout syndrome of the petrous apex causing chronic cerebrospinal fluid leak","volume":"31","author":"Cushing","year":"2010"},{"key":"b4-spine131064","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3171\/2011.3.JNS10434","article-title":"Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acidbased photodynamic treatment. 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