{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:53:56Z","timestamp":1791312836683,"version":"4.3.1"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>OBJECT<\/jats:title><jats:p>World Health Organization Grade 2 meningiomas are aggressive tumors associated with a high recurrence rate leading to repeated surgical procedures, which can seriously worsen a patient's neurological status. Although radiosurgery is an increasingly popular technique, its role in the management of Grade 2 meningiomas has yet to be defined. In this study the authors aimed to evaluate radiosurgery in achieving control of proven tumor progression occurring after resection of Grade 2 meningioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This retrospective study included consecutive patients who, between 2000 and 2012, had undergone radiosurgery for radiologically proven progression of a previously surgically treated Grade 2 meningioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty-seven patients were eligible for analysis. There were 9 men and 18 women with a mean age of 59 years. The mean radiation dose was 15.2 Gy (range 12\u201321 Gy), and the mean target volume was 5.4 cm<jats:sup>3<\/jats:sup>(range 0.194\u201314.2 cm<jats:sup>3<\/jats:sup>). Thirty-four radiosurgical procedures were performed in the 27 patients. The mean progression-free survival after radiosurgery was 32.4 months among those with progression in a target irradiated volume and 26.4 months among those with progression in any intracranial meninges. With a mean follow-up of 56.4 months (range 12\u2013108 months), the 12-, 24-, and 36-month actuarial local control rates for all patients were 75%, 52%, and 40%, respectively, and the regional control rates were 75%, 48%, and 33%. A single case of transient hemiparesis completely resolved without sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Radiosurgery appears to be a safe and effective treatment for the local control of delayed progression after resection of a Grade 2 meningioma. Higher radiation doses similar to those applied for malignant tumors should be recommended when possible.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.9.jns14233","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T14:58:59Z","timestamp":1425653939000},"page":"1157-1162","source":"Crossref","is-referenced-by-count":33,"title":["Grade 2 meningioma and radiosurgery"],"prefix":"10.3171","volume":"122","author":[{"given":"Rabih","family":"Aboukais","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahed","family":"Zairi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Le Rhun","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Vermandel","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Blond","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Devos","sequence":"additional","affiliation":[{"name":"Statistics, Lille University Hospital, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Reyns","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns14233","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s00701-013-1775-0","article-title":"Early postoperative radiotherapy improves progression free survival in patients with grade 2 meningioma","volume":"155","author":"Aboukais","year":"2013"},{"key":"b2-jns14233","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.ijrobp.2011.08.010","article-title":"Long-term outcome after radiotherapy in patients with atypical and malignant meningiomas\u2014clinical results in 85 patients treated in a single institution leading to optimized guidelines for early radiation therapy","volume":"83","author":"Adeberg","year":"2012"},{"key":"b3-jns14233","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11060-012-0828-1","article-title":"Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery","volume":"108","author":"Attia","year":"2012"},{"key":"b4-jns14233","series-title":"J Neurosurg Sci","first-page":"21","article-title":"Therapeutic strategy of late cerebral radionecrosis. 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