{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:31:57Z","timestamp":1791235917235,"version":"4.1.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Pediatric intracranial aneurysms are exceedingly rare and account for less than 5% of all intracranial aneurysms. Open surgery to treat such aneurysms has been shown to be more durable than endovascular techniques, and durability of treatment is particularly important in the pediatric population. Over the past 2 decades, however, a marked shift in aneurysm treatment from open surgery toward endovascular procedures has occurred for adults.<\/jats:p>\n<jats:p>The authors describe their early experience in treating 3 unruptured pediatric brain aneurysms using the Pipeline embolization device (PED). The first patient, a girl with Majewski osteodysplastic primordial dwarfism Type II who was harboring multiple intracranial aneurysms, underwent two flow diversion procedures for a vertebrobasilar aneurysm and a supraclinoid internal carotid artery aneurysm. The second patient underwent PED placement on a previously coiled but enlarging posterior communicating artery aneurysm. All procedures were uneventful, with no postsurgical complications, and led to complete angiographic obliteration of the aneurysms. To the authors' knowledge, this is the first series of flow diversion procedures in children reported in the medical literature.<\/jats:p>\n<jats:p>While flow diversion is a new and relatively untested technology in children, outcomes in adults have been promising. For challenging lesions in the pediatric population, flow diversion may have a valuable role as a well-tolerated, safe treatment with durable results. Many issues remain to be addressed, such as the durability of flow diverters over a very long follow-up and vessel response to growth in the presence of an endoluminal device.<\/jats:p>","DOI":"10.3171\/2014.9.peds14333","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T14:59:45Z","timestamp":1420210785000},"page":"276-281","source":"Crossref","is-referenced-by-count":55,"title":["Flow diversion for complex intracranial aneurysms in young children"],"prefix":"10.3171","volume":"15","author":[{"given":"Ramon","family":"Navarro","sequence":"first","affiliation":[{"name":"Endovascular Surgical Neuroradiology, Mayo Clinic;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Endovascular Surgical Neuroradiology, Mayo Clinic;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Beier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, University of Florida College of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Ranalli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, University of Florida College of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Aldana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, University of Florida College of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Hanel","sequence":"additional","affiliation":[{"name":"Endovascular Surgical Neuroradiology, Mayo Clinic;"},{"name":"Department of Pediatric Neurosurgery, University of Florida College of Medicine; and"},{"name":"Lyerly Neurosurgery, Baptist Hospital, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds14333","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3171\/2014.4.PEDS13213","article-title":"Optic chiasm compression from mass effect and thrombus formation following unsuccessful treatment of a giant supraclinoid ICA aneurysm with the Pipeline device: open surgical bailout with STA-MCA bypass and parent vessel occlusion","volume":"14","author":"Abla","year":"2014"},{"key":"b2-peds14333","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1007\/s00381-005-1152-2","article-title":"The role of endovascular treatment for pediatric aneurysms","volume":"21","author":"Agid","year":"2005"},{"key":"b3-peds14333","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3171\/2014.4.PEDS13464","article-title":"Treatment of cerebral aneurysms in children: analysis of the Kids' Inpatient Database","volume":"14","author":"Alawi","year":"2014"},{"key":"b4-peds14333","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"E623","DOI":"10.1227\/01.NEU.0000365370.82554.08","article-title":"Infectious aneurysm of the cavernous carotid artery in a child treated with a new-generation of flow-diverting stent graft: case report","volume":"66","author":"Appelboom","year":"2010"},{"key":"b5-peds14333","series-title":"Am J Med Genet A","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1002\/ajmg.a.33252","article-title":"Majewski osteodysplastic primordial dwarfism type II (MOPD II): expanding the vascular phenotype","volume":"152A","author":"Bober","year":"2010"},{"key":"b6-peds14333","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00381-013-2336-9","article-title":"Pediatric intracranial aneurysms\u2014our experience and review of literature","volume":"30","author":"Garg","year":"2014"},{"key":"b7-peds14333","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.surneu.2004.11.023","article-title":"Intracranial aneurysms in the pediatric population: case series and literature review","volume":"63","author":"Huang","year":"2005"},{"key":"b8-peds14333","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1227\/01.NEU.0000371727.71991.64","article-title":"Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes","volume":"67","author":"Kakarla","year":"2010"},{"key":"b9-peds14333","series-title":"Interv Neuroradiol","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/159101999700300304","article-title":"Aneurysmal disease in children. Review of 20 cases with intracranial arterial localisations","volume":"3","author":"Lasjaunias","year":"1997"},{"key":"b10-peds14333","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00381-008-0725-2","article-title":"The clinical features and treatment of pediatric intracranial aneurysm","volume":"25","author":"Liang","year":"2009"},{"key":"b11-peds14333","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jocn.2013.03.014","article-title":"Treatment of unruptured intracranial aneurysms with the pipeline embolization device","volume":"21","author":"Murthy","year":"2014"},{"issue":"2 Suppl","key":"b12-peds14333","series-title":"J Neurosurg","first-page":"82","article-title":"Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular management","volume":"104","author":"Sanai","year":"2006"},{"key":"b13-peds14333","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3171\/2012.5.PEDS1210","article-title":"Intracranial pediatric aneurysms: endovascular treatment and its outcome","volume":"10","author":"Saraf","year":"2012"},{"key":"b14-peds14333","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1227\/01.NEU.0000327573.42267.CC","article-title":"Endovascular and surgical treatment of ruptured cerebral aneurysms in pediatric patients","volume":"63","author":"Stiefel","year":"2008"},{"key":"b15-peds14333","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00381-012-1945-z","article-title":"Pediatric intracranial aneurysms: current national trends in patient management and treatment","volume":"29","author":"Vasan","year":"2013"},{"key":"b16-peds14333","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3171\/2009.6.PEDS08137","article-title":"Multiple intracranial aneurysms and moyamoya disease associated with microcephalic osteodysplastic primordial dwarfism type II: surgical considerations","volume":"4","author":"Waldron","year":"2009"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/15\/3\/article-p276.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/15\/3\/article-p276.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/15\/3\/article-p276.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T20:08:13Z","timestamp":1681589293000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/15\/3\/article-p276.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":16,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2014.9.peds14333","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}