{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:19:33Z","timestamp":1770887973463,"version":"3.50.1"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The authors delineate the long-term results of surgical treatment for pediatric low-grade midbrain glioma.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A series of 15 consecutive patients (age range 0\u201315 years) who underwent primary tumor resection for a low-grade midbrain glioma during the years 1989\u20132010 were included in this retrospective study on surgical morbidity, mortality rate, academic achievement, and\/or work participation. Gross motor function and activities of daily living were scored according to the Barthel Index.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Of the 15 patients, 10 were in their 1st decade (age 0\u20139 years) and 5 were in their 2nd decade of life (age 10\u201315 years) at the time of surgery. The male\/female ratio was 0.50 (5:10). No patients were lost to follow-up. One patient died in the postoperative period (32 days posttreatment). Another 2 patients died during follow-up. One patient succumbed to acute bleeding in the resection cavity 8 months after surgery, and the other died of shunt failure 21 years after initial treatment. Twelve patients are alive at the time of this writing, with follow-up periods from 3 to 24 years (median 8 years).<\/jats:p>\n<jats:p>Among the 12 survivors, the Barthel Index scores were normal (100) in 11 patients and 80 in 1 patient. A total of 25 tumor resections were performed. In 1 patient, further resection was performed 5 days after initial resection due to MRI-confirmed residual tumor. Another 5 patients underwent repeat tumor resection after MRI-confirmed progressive tumor disease and clinical deterioration ranging from 3 months to 4 years after the initial operation. Three of these 5 patients also underwent a third resection, and 1 of the 3 underwent a fourth operation. Six children received adjuvant therapy: local radiotherapy in 2 patients, chemotherapy in 3 patients, and both in 1 patient. Twelve (80%) of the 15 patients needed treatment for persistent hydrocephalus.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Selected cases of low-grade midbrain gliomas may clearly benefit from resection with favorable results, even for prolonged periods. Three patients in the present series died, one of whom had a prolonged survival period of 21 years. Among the 12 survivors, stable long-term results appeared obtainable in at least 9. One patient died of acute hemorrhage 8 months after initial resection; otherwise, rapid tumor progression and death were not observed. Forty percent of the patients received adjuvant treatment, with local radiotherapy, chemotherapy, or both.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.9.peds1462","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T13:58:48Z","timestamp":1413554328000},"page":"598-603","source":"Crossref","is-referenced-by-count":12,"title":["Neurosurgical treatment of pediatric low-grade midbrain tumors: a single consecutive institutional series of 15 patients"],"prefix":"10.3171","volume":"14","author":[{"given":"Tryggve","family":"Lundar","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernt Johan","family":"Due-T\u00f8nnessen","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arild","family":"Egge","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Scheie","sequence":"additional","affiliation":[{"name":"Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Brandal","sequence":"additional","affiliation":[{"name":"Oncology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Stensvold","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Due-T\u00f8nnessen","sequence":"additional","affiliation":[{"name":"Radiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds1462","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/BF00335126","article-title":"Benign cerebellar astrocytoma in childhood: experience at the Hospital for Sick Children 1980\u20131992","volume":"10","author":"Abdollahzadeh","year":"1994"},{"key":"b2-peds1462","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3171\/jns.1986.65.6.0751","article-title":"Prognostic factors in pediatric brain-stem gliomas","volume":"65","author":"Albright","year":"1986"},{"key":"b3-peds1462","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3171\/2012.11.PEDS12265","article-title":"Neurosurgical treatment of low grade cerebellar astrocytoma in children and adolescents: a single institution series of 100 patients. 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