{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:02:24Z","timestamp":1787025744481,"version":"build-2736575974"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECT<\/jats:title>\n                    <jats:p>The study aim was to examine the effect of gradually reducing the opening pressure on symptoms and signs in the shunt treatment of idiopathic normal pressure hydrocephalus (iNPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In this prospective double-blinded, randomized, controlled, double-center study on patients with iNPH, a ventriculoperitoneal shunt with an adjustable Codman Medos Valve was implanted in 68 patients randomized into 2 groups. In 1 group (the 20\u20134 group) the valve setting was initially set to 20 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O and gradually reduced to 4 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O over the course of the 6-month study period. In the other group (the 12 group), the valve was kept at a medium level of 12 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O during the whole study period. All patients were clinically evaluated using 4 tests preoperatively as well as postoperatively at 1, 2, 3, 4, and 6 months. The test scores between the 2 groups (20\u20134 and 12) were compared for each clinical evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Fifty-five patients (81%) were able to complete the study. There were no significant differences between the 2 groups (20\u20134 and 12) preoperatively or at any time postoperatively. Both groups exhibited significant clinical improvement after shunt insertion at all valve settings compared with the preoperative score, with the greatest improvement observed at the first postoperative evaluation. The clinical improvement was significant within the first 3 months, and thereafter no significant improvement was seen in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Gradual reduction of the valve setting from 20 to 4 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O did not improve outcome compared with a fixed valve setting of 12 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O. Improvement after shunt surgery in iNPH patients was evident within 3 months, irrespective of valve setting.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2015.1.jns141301","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:50:23Z","timestamp":1440762623000},"page":"359-367","source":"Crossref","is-referenced-by-count":31,"title":["A double-blind randomized trial on the clinical effect of different shunt valve settings in idiopathic normal pressure hydrocephalus"],"prefix":"10.3171","volume":"124","author":[{"given":"Dan","family":"Farahmand","sequence":"first","affiliation":[{"name":"Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje","family":"S\u00e6hle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Kristian","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and"},{"name":"Faculty of Medicine, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Tisell","sequence":"additional","affiliation":[{"name":"Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 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