{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:51:41Z","timestamp":1769125901933,"version":"3.49.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>Progressive postnatal pansynostosis (PPP) is a rare form of craniosynostosis that is characterized by a normal head shape, insidious decrease in percentile head circumference, and high rates of elevated intracranial pressure (ICP). This investigation describes the clinical, radiographic, and genetic features of this entity.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors\u2019 craniofacial database for the period 1997\u20132013 was retrospectively culled to identify patients who had a normal or near-normal head shape and CT-confirmed multiple-suture synostosis. Patients with kleeblatt-sch\u00e4del or previous craniofacial surgery were excluded. All demographic information was collected and analyzed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Seventeen patients fit the inclusion criteria. Nine patients had a syndromic diagnosis: Crouzon syndrome (n = 4), Pfeiffer syndrome (n = 2), Saethre-Chotzen syndrome (n = 1), Apert syndrome (n = 1), and achondroplasia (n = 1). With the exception of 3 patients with mild turricephaly, all patients had a relatively normal head shape. Patients were diagnosed at an average age of 62.9 months. Nearly all patients had some combination of clinical, radiographic, or ophthalmological evidence of increased ICP.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>PPP is insidious; diagnosis is typically delayed because the clinical signs are subtle and appear gradually. All normocephalic infants or children with a known or suspected craniosynostotic disorder should be carefully monitored; any decrease in percentile head circumference or signs\/symptoms of increased ICP should prompt CT evaluation.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.1.peds14464","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T14:06:25Z","timestamp":1433513185000},"page":"309-316","source":"Crossref","is-referenced-by-count":30,"title":["Progressive postnatal pansynostosis: an insidious and pernicious form of craniosynostosis"],"prefix":"10.3171","volume":"16","author":[{"given":"Benjamin C.","family":"Wood","sequence":"first","affiliation":[{"name":"Departments of Plastic Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert K.","family":"Oh","sequence":"additional","affiliation":[{"name":"Departments of Plastic Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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