{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:31:10Z","timestamp":1770895870720,"version":"3.50.1"},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>This case report documents the migration of 3 iodine-125 (<jats:sup>125<\/jats:sup>I) seeds from the tumor resection cavity into brain parenchyma over a 7-year period. A 66-year-old woman had a history of metastatic ovarian carcinoma, nickel allergy, and reaction to a titanium hip implant that required reoperation for hardware removal. In this unique case of parenchymal migration, the seed paths seemed to follow white matter tracts, traveling between 18.5 and 35.5 mm from the initial implant site. The patient's initial neurological decline, which was thought to be related to radiation necrosis, appeared to stabilize with medical therapy. She subsequently developed progressive right hemispheric edema that resulted in neurological deterioration and death. Considering her previous reactions to nickel and titanium, the authors now speculate that her later clinical course reflected an allergic reaction to the titanium casing of the <jats:sup>125<\/jats:sup>I seeds. Containing a trace amount of nickel, <jats:sup>125<\/jats:sup>I seeds can elicit a delayed hypersensitivity reaction in patients with a history of nickel dermatitis. Preoperative patch testing is recommended in these patients, and <jats:sup>125<\/jats:sup>I seed implantation should be avoided in those who test positive.<\/jats:p>","DOI":"10.3171\/2015.11.jns151464","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T15:05:01Z","timestamp":1456499101000},"page":"1167-1170","source":"Crossref","is-referenced-by-count":17,"title":["Iodine-125 seed migration within brain parenchyma after brachytherapy for brain metastasis: case report"],"prefix":"10.3171","volume":"125","author":[{"given":"Bledi","family":"Brahimaj","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois;\u00a0"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lamba","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"},{"name":"Brain Tumor Center at University of Cincinnati Neuroscience Institute; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Breneman","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"},{"name":"Brain Tumor Center at University of Cincinnati Neuroscience Institute; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald E.","family":"Warnick","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Cincinnati College of Medicine;"},{"name":"Brain Tumor Center at University of Cincinnati Neuroscience Institute; and"},{"name":"Mayfield Clinic, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4 Suppl 4","key":"b1-jns151464","series-title":"Surg Neurol Int","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.4103\/2152-7806.134813","article-title":"Life-threatening allergic vasculitis after clipping an unruptured aneurysm: case report, weighing the risk of nickel allergy","volume":"5","author":"Grande","year":"2014"},{"key":"b2-jns151464","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11060-008-9686-2","article-title":"Surgical resection and permanent iodine-125 brachytherapy for brain metastases","volume":"91","author":"Huang","year":"2009"},{"key":"b3-jns151464","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2214\/AJR.09.3957","article-title":"Radiation dose for routine clinical adult brain CT: Variability on different scanners at one institution","volume":"195","author":"Jaffe","year":"2010"},{"key":"b4-jns151464","series-title":"Neuro Oncol","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1215\/S1152851703000425","article-title":"Permanent iodine 125 brachytherapy in patients with progressive or recurrent glioblastoma multiforme","volume":"6","author":"Larson","year":"2004"},{"key":"b5-jns151464","series-title":"Biomed Res Int","first-page":"137287","article-title":"Biomaterial hypersensitivity: is it real? 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