{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:17:55Z","timestamp":1793377075592,"version":"4.5.0"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2016,6]]},"abstract":"\nOBJECTIVE<\/jats:title>\nMagnetic resonance\u2013guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive treatment that has multiple advantages in pediatric use and broad applicability for different types of lesions. Here, the authors report the preliminary results of the first series of pediatric brain tumors treated with MRgLITT at Golisano Children's Hospital in Syracuse, New York.<\/jats:p><\/jats:sec>\n\nMETHODS<\/jats:title>\nPediatric brain tumors treated with MRgLITT between February 2012 and August 2014 at Golisano Children's Hospital were evaluated retrospectively. Medical records, radiological findings, surgical data, complications, and results of tumor volumetric analyses were reviewed. The Visualase thermal laser system (Medtronic) was used in all MRgLITT procedures.<\/jats:p><\/jats:sec>\n\nRESULTS<\/jats:title>\nThis series included 11 patients with 12 tumors (pilocytic astrocytoma, ependymoma, medulloblastoma, choroid plexus xanthogranuloma, subependymal giant cell astrocytoma, and ganglioglioma). A single laser and multiple overlapping ablations were used for all procedures. The mean laser dose was 10.23 W, and the mean total ablation time was 68.95 seconds. The mean initial target volume was 6.79 cm3<\/jats:sup>, and the mean immediate post-ablation volume was 7.86 cm3<\/jats:sup>. The mean hospital stay was 3.25 days, and the mean follow-up time was 24.5 months. Tumor volume decreased in the first 3 months after surgery (n = 11; p = 0.007) and continued to decrease by the 4- to 6-month followup (n = 11; mean volume 2.61 cm3<\/jats:sup>; p = 0.009). Two patients experienced post-ablation complications: transient right leg weakness in one patient, and transient hemiparesis, akinetic mutism, and eye movement disorder in the other.<\/jats:p><\/jats:sec>\n\nCONCLUSIONS<\/jats:title>\nMagnetic resonance\u2013guided laser interstitial thermal therapy is an effective first- or second-line treatment for select pediatric brain tumors. Larger multiinstitutional clinical trials are necessary to evaluate its use for different types of lesions to further standardize practices.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.11.peds15242","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T14:58:43Z","timestamp":1454684323000},"page":"723-733","source":"Crossref","is-referenced-by-count":64,"title":["Magnetic resonance\u2013guided laser interstitial thermal therapy: report of a series of pediatric brain tumors"],"prefix":"10.3171","volume":"17","author":[{"given":"Zulma","family":"Tovar-Spinoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds15242","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s11060-010-0511-3","article-title":"Photothermal treatment of glioma; an in vitro study of macrophage-mediated delivery of gold nanoshells","volume":"104","author":"Baek","year":"2011"},{"key":"b2-peds15242","series-title":"Acta Neurochir Suppl (Wien)","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-7091-9160-6_23","article-title":"Stereotactic laser therapy in cerebral gliomas","volume":"52","author":"Bettag","year":"1991"},{"key":"b3-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/lsm.22025","article-title":"MR-guided laser-induced thermal therapy (LITT) for recurrent glioblastomas","volume":"44","author":"Carpentier","year":"2012"},{"key":"b4-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/lsm.21138","article-title":"Laser thermal therapy: real-time MRI-guided and computer-controlled procedures for metastatic brain tumors","volume":"43","author":"Carpentier","year":"2011"},{"issue":"1 Suppl 1","key":"b5-peds15242","series-title":"Neurosurgery","first-page":"ONS21","article-title":"Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors","volume":"63","author":"Carpentier","year":"2008"},{"key":"b6-peds15242","series-title":"Photonics Lasers Med","first-page":"107","article-title":"MRI-guided laser interstitial thermal therapy of intracranial tumors and epilepsy: State-of-the-art review and a case study from pediatrics","volume":"3","author":"Choi","year":"2014"},{"key":"b7-peds15242","series-title":"Epilepsy Behav","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.yebeh.2012.04.135","article-title":"MR-guided stereotactic laser ablation of epileptogenic foci in children","volume":"24","author":"Curry","year":"2012"},{"issue":"Suppl 14","key":"b8-peds15242","series-title":"Fed Proc","first-page":"129","article-title":"Central nervous system effects of laser radiation","volume":"24","author":"Earle","year":"1965"},{"issue":"Suppl 14","key":"b9-peds15242","series-title":"Fed Proc","first-page":"35","article-title":"Interaction of laser radiation with biologic systems. I Studies on interaction with tissues","volume":"24","author":"Fine","year":"1965"},{"key":"b10-peds15242","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1227\/NEU.0000000000000144","article-title":"Magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions: single-institution series","volume":"73","author":"Hawasli","year":"2013"},{"key":"b11-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/1096-9101(2001)28:1<80::AID-LSM1020>3.0.CO;2-1","article-title":"Metabolic activity and DNA integrity in human hepatic metastases after interstitial laser coagulation (ILC)","volume":"28","author":"Heisterkamp","year":"2001"},{"issue":"1 Suppl Operative","key":"b12-peds15242","series-title":"Neurosurgery","first-page":"133","article-title":"Magnetic resonance thermometry-guided laser-induced thermal therapy for intracranial neoplasms: initial experience","volume":"71","author":"Jethwa","year":"2012"},{"key":"b13-peds15242","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3171\/2011.8.PEDS11148","article-title":"Treatment of a supratentorial primitive neuroectodermal tumor using magnetic resonance-guided laser-induced thermal therapy","volume":"8","author":"Jethwa","year":"2011"},{"key":"b14-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/lsm.20069","article-title":"Thermal therapy of canine cerebral tumors using a 980 nm diode laser with MR temperature-sensitive imaging feedback","volume":"35","author":"Kangasniemi","year":"2004"},{"key":"b15-peds15242","series-title":"Evaluation of Chemotherapeutic Agents","first-page":"191","article-title":"The clinical evaluation of chemotherapeutic agents in cancer","author":"Karnofsky","year":"1949"},{"key":"b16-peds15242","series-title":"Minim Invasive Neurosurg","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1055\/s-2001-13581","article-title":"Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR-unit","volume":"44","author":"Leonardi","year":"2001"},{"key":"b17-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/lsm.1900050202","article-title":"Temperature rise in biological tissue during Nd:YAG laser irradiation","volume":"5","author":"Marchesini","year":"1985"},{"key":"b18-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/lsm.10243","article-title":"MR thermometry-based feedback control of laser interstitial thermal therapy at 980 nm","volume":"34","author":"McNichols","year":"2004"},{"key":"b19-peds15242","series-title":"Int J Hyperthermia","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/02656730310001611035","article-title":"Technical developments for cerebral thermal treatment: water-cooled diffusing laser fibre tips and temperature-sensitive MRI using intersecting image planes","volume":"20","author":"McNichols","year":"2004"},{"issue":"3","key":"b20-peds15242","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.3171\/2014.12.FOCUS14762","article-title":"Renaissance of laser interstitial thermal ablation","volume":"38","author":"Missios","year":"2015"},{"key":"b21-peds15242","series-title":"Cancer Med","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/cam4.266","article-title":"The role of laser interstitial thermal therapy in enhancing progression-free survival of difficult-to-access high-grade gliomas: a multicenter study","volume":"3","author":"Mohammadi","year":"2014"},{"key":"b22-peds15242","series-title":"BioMed Res Int","first-page":"761312","article-title":"Magnetic resonance-guided laser induced thermal therapy for glioblastoma multiforme: a review","volume":"2014","author":"Norred","year":"2014"},{"key":"b23-peds15242","series-title":"Lasers Surg Med Aug","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/lsm.22151","article-title":"Volumetric trends associated with MRI-guided laser-induced thermal therapy (LITT) for intracranial tumors","volume":"45","author":"Patel","year":"2013"},{"key":"b24-peds15242","series-title":"Oncology","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000362817","article-title":"MRI-guided laser interstitial thermal therapy in neuro-oncology: a review of its current clinical applications","volume":"87","author":"Rahmathulla","year":"2014"},{"key":"b25-peds15242","series-title":"Transl Pediatr","first-page":"229","article-title":"Laser induced thermal therapy (LITT) for pediatric brain tumors: case-based review","volume":"3","author":"Riordan","year":"2014"},{"key":"b26-peds15242","series-title":"Acta Neurochir (Wien)","first-page":"803","article-title":"Laser-induced thermotherapy of neoplastic lesions in the brain\u2014underlying tissue alterations, MRI-monitoring and clinical applicability","volume":"146","author":"Schulze","year":"2004"},{"key":"b27-peds15242","series-title":"Med Laser Appl","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1078\/1615-1615-00057","article-title":"Basic principles of laser induced interstitial thermotherapy in brain tumors","volume":"17","author":"Schwarzmaier","year":"2002"},{"key":"b28-peds15242","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3171\/2013.1.JNS1291","article-title":"Results of the NeuroBlate System first-in-humans Phase I clinical trial for recurrent glioblastoma: clinical article","volume":"118","author":"Sloan","year":"2013"},{"key":"b29-peds15242","series-title":"Crit Rev Biomed Eng","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1615\/CritRevBiomedEng.v38.i1.70","article-title":"Laser-induced thermal therapy for tumor ablation","volume":"38","author":"Stafford","year":"2010"},{"key":"b30-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/lsm.1900050607","article-title":"Thermal and optical properties of living tissue: application to laser-induced hyperthermia","volume":"5","author":"Svaasand","year":"1985"},{"key":"b31-peds15242","series-title":"Photochem Photobiol","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1751-1097.1985.tb03450.x","article-title":"Optical penetration in human intracranial tumors","volume":"41","author":"Svaasand","year":"1985"},{"key":"b32-peds15242","series-title":"Photochem Photobiol","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1751-1097.1983.tb02674.x","article-title":"Optical properties of human brain","volume":"38","author":"Svaasand","year":"1983"},{"key":"b33-peds15242","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s11060-013-1142-2","article-title":"Stereotactic laser induced thermotherapy (LITT): a novel treatment for brain lesions regrowing after radiosurgery","volume":"113","author":"Torres-Reveron","year":"2013"},{"key":"b34-peds15242","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00381-013-2169-6","article-title":"The use of MRI-guided laser-induced thermal ablation for epilepsy","volume":"29","author":"Tovar-Spinoza","year":"2013"},{"key":"b35-peds15242","series-title":"Lasers Surg Med","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/lsm.1900130110","article-title":"Comparison of magnetic resonance images and the histopathological findings of lesions induced by interstitial laser photocoagulation in the brain","volume":"13","author":"Tracz","year":"1993"},{"key":"b36-peds15242","series-title":"Photonics Lasers Med","first-page":"77","article-title":"Laser interstitial thermal therapy with and without MRI guidance for treatment of brain neoplasms. A systematic review of the literature","volume":"3","author":"Voigt","year":"2014"},{"key":"b37-peds15242","series-title":"Med Laser Appl","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1078\/1615-1615-00060","article-title":"LITT (laser-induced interstitial thermotherapy) of benign and malignant gliomas in the open MRT (0.5 Tesla, GE Signa SP)","volume":"17","author":"von Tempelhoff","year":"2002"},{"key":"b38-peds15242","series-title":"Photonics Lasers Med","first-page":"67","article-title":"Laser interstitial thermal therapy (LITT) of the brain","volume":"3","author":"von Tempelhoff","year":"2014"},{"key":"b39-peds15242","series-title":"Optical\u2013Thermal Response of Laser-Irradiated Tissue","author":"Welch","year":"1995"},{"key":"b40-peds15242","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1227\/NEU.0000000000000343","article-title":"Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy","volume":"74","author":"Willie","year":"2014"},{"key":"b41-peds15242","series-title":"Phys Med Biol","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1088\/0031-9155\/47\/12\/305","article-title":"Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range","volume":"47","author":"Yaroslavsky","year":"2002"},{"key":"b42-peds15242","series-title":"Med Phys","doi-asserted-by":"publisher","first-page":"5313","DOI":"10.1118\/1.3490085","article-title":"Quantitative comparison of thermal dose models in normal canine brain","volume":"37","author":"Yung","year":"2010"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/17\/6\/article-p723.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/17\/6\/article-p723.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/17\/6\/article-p723.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T13:15:36Z","timestamp":1681564536000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/17\/6\/article-p723.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":42,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2015.11.peds15242","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}