{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:14:53Z","timestamp":1769148893433,"version":"3.49.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Craniopharyngioma is a benign, cystic suprasellar tumor that can be treated with intracystic chemotherapy. Interferon-\u03b1 (IFN-\u03b1) has been gaining popularity as an intracystic treatment for craniopharyngioma because of its efficacy and supposed benign neurotoxicity profile. In this case report the authors describe a patient who, while receiving intracystic IFN-\u03b1, suffered a neurological event, which was believed to be related to drug leakage outside the cyst. This is the first report of a focal neurological deficit potentially attributable to intracystic IFN-\u03b1 therapy, highlighting the fact that IFN-\u03b1 may have neurotoxic effects on the central nervous system. Given this case and the results of a literature review, the authors suggest that a positive leak test is a relative contraindication to intracystic IFN-\u03b1 treatment.<\/jats:p>","DOI":"10.3171\/2015.2.peds14656","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:03:50Z","timestamp":1432908230000},"page":"301-304","source":"Crossref","is-referenced-by-count":17,"title":["Intracystic interferon-\u03b1 treatment leads to neurotoxicity in craniopharyngioma: case report"],"prefix":"10.3171","volume":"16","author":[{"given":"Julia","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of British Columbia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Bonfield","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Surgery, University of British Columbia and British Columbia Children\u2019s Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ash","family":"Singhal","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of British Columbia;"},{"name":"Division of Pediatric Neurosurgery, Department of Surgery, University of British Columbia and British Columbia Children\u2019s Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Hukin","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Steinbok","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of British Columbia;"},{"name":"Division of Pediatric Neurosurgery, Department of Surgery, University of British Columbia and British Columbia Children\u2019s Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds14656","series-title":"J Immunol","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.4049\/jimmunol.161.9.5016","article-title":"Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration","volume":"161","author":"Akwa","year":"1998"},{"key":"b2-peds14656","series-title":"Front Endocrinol (Lausanne)","first-page":"39","article-title":"Intracystic therapies for cystic craniopharyngioma in childhood","volume":"3","author":"Bartels","year":"2012"},{"key":"b3-peds14656","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s00381-005-1226-1","article-title":"Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma","volume":"21","author":"Cavalheiro","year":"2005"},{"issue":"4","key":"b4-peds14656","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/2010.1.FOCUS09310","article-title":"Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases","volume":"28","author":"Cavalheiro","year":"2010"},{"key":"b5-peds14656","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1002\/cncr.10547","article-title":"A phase II trial of intra-cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis","volume":"94","author":"Chamberlain","year":"2002"},{"key":"b6-peds14656","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1177\/088307380301801201","article-title":"Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study","volume":"18","author":"Gascon","year":"2003"},{"key":"b7-peds14656","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/ana.410440608","article-title":"Aicardi-Gouti\u00e8res syndrome: an update and results of interferon-alpha studies","volume":"44","author":"Gouti\u00e8res","year":"1998"},{"key":"b8-peds14656","series-title":"Brain Dev","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0387-7604(03)00017-2","article-title":"Combination therapy with intraventricular interferon-alpha and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay","volume":"25","author":"Hara","year":"2003"},{"key":"b9-peds14656","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/cncr.22633","article-title":"Intracystic bleomycin therapy for craniopharyngioma in children: the Canadian experience","volume":"109","author":"Hukin","year":"2007"},{"key":"b10-peds14656","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00381-007-0409-3","article-title":"Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas","volume":"23","author":"Ierardi","year":"2007"},{"issue":"4 Suppl","key":"b11-peds14656","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3171\/ped.2007.107.4.318","article-title":"Neuroradiological findings of bleomycin leakage in cystic craniopharyngioma. Report of three cases","volume":"107","author":"Lafay-Cousin","year":"2007"},{"key":"b12-peds14656","series-title":"Adv Pediatr","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.yapd.2006.04.013","article-title":"Craniopharyngioma in childhood","volume":"53","author":"May","year":"2006"},{"key":"b13-peds14656","series-title":"ICJRI","first-page":"719","article-title":"Unexpected brain atrophy following administration of intratumoral interferon alpha-2b for cystic craniopharyngioma: A case report","volume":"4","author":"Mohammed","year":"2013"},{"key":"b14-peds14656","series-title":"J Neurooncol","first-page":"61","article-title":"Phase I clinical trial of intralesional or intraventricular leukocyte interferon for intracranial malignancies","volume":"3","author":"Obbens","year":"1985"},{"key":"b15-peds14656","series-title":"Pharm World Sci","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s11096-005-1319-7","article-title":"Side effects of interferon-alpha therapy","volume":"27","author":"Sleijfer","year":"2005"},{"issue":"4","key":"b16-peds14656","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.3171\/2010.1.FOCUS09315","article-title":"Intracystic treatments for craniopharyngioma","volume":"28","author":"Steinbok","year":"2010"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/16\/3\/article-p301.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/16\/3\/article-p301.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/16\/3\/article-p301.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:59:31Z","timestamp":1681559971000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/16\/3\/article-p301.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":16,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2015.2.peds14656","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}