{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:18:51Z","timestamp":1792808331182,"version":"4.5.0"},"reference-count":70,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECT<\/jats:title>\n                    <jats:p>Meningioma is the most common benign intracranial tumor, and patients with supratentorial meningioma frequently suffer from seizures. The rates and predictors of seizures in patients with meningioma have been significantly under-studied, even in comparison with other brain tumor types. Improved strategies for the prediction, treatment, and prevention of seizures in patients with meningioma is an important goal, because tumor-related epilepsy significantly impacts patient quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors performed a systematic review of PubMed for manuscripts published between January 1980 and September 2014, examining rates of pre- and postoperative seizures in supratentorial meningioma, and evaluating potential predictors of seizures with separate meta-analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The authors identified 39 observational case series for inclusion in the study, but no controlled trials. Preoperative seizures were observed in 29.2% of 4709 patients with supratentorial meningioma, and were significantly predicted by male sex (OR 1.74, 95% CI 1.30\u20132.34); an absence of headache (OR 1.77, 95% CI 1.04\u20133.25); peritumoral edema (OR 7.48, 95% CI 6.13\u20139.47); and non\u2013skull base location (OR 1.77, 95% CI 1.04\u20133.25). After surgery, seizure freedom was achieved in 69.3% of 703 patients with preoperative epilepsy, and was more than twice as likely in those without peritumoral edema, although an insufficient number of studies were available for formal meta-analysis of this association. Of 1085 individuals without preoperative epilepsy who underwent resection, new postoperative seizures were seen in 12.3% of patients. No difference in the rate of new postoperative seizures was observed with or without perioperative prophylactic anticonvulsants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Seizures are common in supratentorial meningioma, particularly in tumors associated with brain edema, and seizure freedom is a critical treatment goal. Favorable seizure control can be achieved with resection, but evidence does not support routine use of prophylactic anticonvulsants in patients without seizures. Limitations associated with systematic review and meta-analysis should be considered when interpreting these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2015.4.jns142742","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:47:20Z","timestamp":1449236840000},"page":"1552-1561","source":"Crossref","is-referenced-by-count":155,"title":["Seizures in supratentorial meningioma: a systematic review and meta-analysis"],"prefix":"10.3171","volume":"124","author":[{"given":"Dario J.","family":"Englot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Magill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunggu J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel S.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns142742","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s003819900205","article-title":"Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature","volume":"16","author":"Amirjamshidi","year":"2000"},{"key":"b2-jns142742","series-title":"Epileptic Disord","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1684\/epd.2010.0303","article-title":"The evolution of antiepileptic drug development and regulation","volume":"12","author":"Arzimanoglou","year":"2010"},{"key":"b3-jns142742","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1136\/jnnp.67.4.474","article-title":"Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects","volume":"67","author":"Beenen","year":"1999"},{"key":"b4-jns142742","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00701-008-0006-6","article-title":"Surgical strategies for giant medial sphenoid wing meningiomas: a new scoring system for predicting extent of resection","volume":"150","author":"Behari","year":"2008"},{"key":"b5-jns142742","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.wneu.2012.02.051","article-title":"Seizure control for patients undergoing meningioma surgery","volume":"79","author":"Chaichana","year":"2013"},{"key":"b6-jns142742","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3171\/jns.1984.60.1.0052","article-title":"Morbidity, mortality, and quality of life following surgery for intracranial meningiomas. 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