{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:04:21Z","timestamp":1770512661470,"version":"3.49.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>Congenital hydrocephalus has a major impact on the lives of patients and their relatives, as well as their long-term neurological development and social integration. The aim of this study was to assess the self-reported health-related quality of life (HRQOL) of patients after reaching adulthood.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A total of 31 patients who required CSF shunt treatment for congenital hydrocephalus within the 1st year of life (between 1963 and 1987) agreed to undergo a structured SF-36 self-assessment. An age-matched German standard cohort was used as control. Additional parameters of surgical, social, and global neurological outcome were analyzed. The mean patient age was 35 years (range 26\u201351 years, 13 females and 18 males). Hydrocephalus etiologies were posthemorrhagic hydrocephalus (n = 9), postinfectious hydrocephalus (n = 5), aqueductal stenosis (n = 10), myelomeningocele (n = 2), and unknown cause (n = 5).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The mean modified Rankin Scale score was 1.6 (range 0\u20134). Hydrocephalic patients achieved lower scores for the SF-36 items physical functioning (70.5 vs 93.5, p &lt; 0.05), physical role functioning (74.2 vs 88.3, p &lt; 0.05), and general health perceptions (64.5 vs 72.3, p &lt; 0.05). Emotional, social role functioning, and mental health items did not differ between the groups. Assessment of vitality and pain resulted in a trend to worse values. Whereas the Physical Component Summary score was lower (46.1 vs 54.3, p &lt; 0.05), the Mental Component Summary score was not significantly different (50.2 vs 48.7, p = 0.3). There was neither a statistically significant difference between subgroups of different etiologies nor an association with the number of subsequent hydrocephalus-related surgeries.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Adult HRQOL for patients with congenital hydrocephalus appears to be similar to that for healthy con with regard to mental health and social functioning aspects. Physical impairment is a predominant factor of compro quality of life.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.4.peds15106","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T13:59:09Z","timestamp":1441375149000},"page":"621-625","source":"Crossref","is-referenced-by-count":24,"title":["Adult long-term health-related quality of life of congenital hydrocephalus patients"],"prefix":"10.3171","volume":"16","author":[{"given":"Anja","family":"Kutscher","sequence":"first","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Nestler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias K.","family":"Bernhard","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Merkenschlager","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Thome","sequence":"additional","affiliation":[{"name":"Department of Neonatology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieland","family":"Kiess","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schob","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, University Hospital Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Meixensberger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Preuss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds15106","series-title":"Bundesgesundheitsbl","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00103-013-1700-y","article-title":"Gesundheitsbezogene Lebensqualit\u00e4t bei Erwachsenen in Deutschland","volume":"56","author":"Ellert","year":"2013"},{"key":"b2-peds15106","series-title":"Dev Med Child Neurol","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1017\/S0012162206001162","article-title":"The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability","volume":"48","author":"Eliasson","year":"2006"},{"key":"b3-peds15106","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/jnnp.54.12.1044","article-title":"The United Kingdom Transient Ischaemic Attack (UK-TIA) Aspirin Trial: final results","volume":"54","author":"Farrell","year":"1991"},{"key":"b4-peds15106","series-title":"J Psychiatr Res","first-page":"189","article-title":"\u201cMini-mental state\u201d. 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