{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:09:08Z","timestamp":1775898548361,"version":"3.50.1"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECT<\/jats:title>\n                    <jats:p>Hemangioblastomas are rare, benign, highly vascularized tumors that can be found throughout the neuraxis but are mainly located in the cerebellum and in the spinal cord. Spinal hemangioblastomas can present with motor and sensory deficits, whose severity varies according to the size and location of the tumor. Resection is the best treatment option to avoid neurological deterioration. The authors report surgical results in the treatment of intramedullary hemangioblastomas and discuss the technical nuances important to achieving total resection without adding new deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A consecutive series of patients with intramedullary hemangioblastomas operated on between 2000 and 2014 by the senior author (H.T.) is presented. The functional scale proposed by McCormick was used to evaluate the patients' neurological status before and after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Sixteen patients were included in the study and underwent 17 surgeries. Follow-up was at least 6 months. Age at presentation varied from 13 to 58 years (mean 33.8 years). Ten patients (62.5%) were males and 6 patients (37.5%) were females. Seven (43.75%) of the 16 patients had associated von Hippel\u2014Lindau syndrome, with hemangioblastomas also presenting in other locations. Three patients had multiple tumors in the same segment in the spinal cord, and 10 patients (62.5%) presented with cysts. According to the site of presentation, 11 tumors (68.75%) were localized at the cervical region (including the cervicomedullary junction) and 5 tumors (31.25%) at the thoracic level. Total resection was achieved in all cases, evidenced by postoperative MRI. Four patients had some functional worsening immediately after surgery. After 6 months, 1 patient had functional worsening compared with preoperative status, and 2 patients had clinical improvement. The majority of the patients remained clinically stable postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Adequate knowledge of anatomy and the correct use of microsurgical techniques allowed total resection of these tumors, with minimal morbidity and maximum functional recovery. Outcome seems to be directly related to the neurological status before surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2015.5.focus15171","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T03:39:09Z","timestamp":1438400349000},"page":"E18","source":"Crossref","is-referenced-by-count":28,"title":["Intramedullary hemangioblastomas: surgical results in 16 patients"],"prefix":"10.3171","volume":"39","author":[{"given":"Andrei F.","family":"Joaquim","sequence":"first","affiliation":[{"name":"Neurosurgery Division,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Ghizoni","sequence":"additional","affiliation":[{"name":"Neurosurgery Division,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Juliano dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Neurosurgery Division,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Gomes C.","family":"Valadares","sequence":"additional","affiliation":[{"name":"Neurosurgery Division,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Soares da","family":"Silva","sequence":"additional","affiliation":[{"name":"State University of Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helder","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Neurosurgery Division,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-focus15171","series-title":"Neurosurgery","first-page":"1215","article-title":"Hemangioblastomas of central nervous system: molecular genetic analysis and clinical management","volume":"56","author":"Catapano","year":"2005"},{"key":"b2-focus15171","series-title":"Neurosurgery","first-page":"28","article-title":"Treatment of hemangioblastomas in von Hippel-Lindau disease with linear accelerator-based radiosurgery","volume":"43","author":"Chang","year":"1998"},{"key":"b3-focus15171","series-title":"Neurosurgery","first-page":"55","article-title":"Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease","volume":"48","author":"Conway","year":"2001"},{"key":"b4-focus15171","series-title":"Acta Neurochir (Wien)","first-page":"333","article-title":"Surgical management of intramedullary hemangioblastoma of the spinal cord","volume":"141","author":"Cristante","year":"1999"},{"key":"b5-focus15171","series-title":"J Clin Neurosci","first-page":"1150","article-title":"Surgical management of intradural extramedullary tumors located anteriorly to the spinal cord","volume":"19","author":"Joaquim","year":"2012"},{"key":"b6-focus15171","series-title":"Spine J","first-page":"1067","article-title":"Postoperative spinal deformity after treatment of intracanal spine lesions","volume":"12","author":"Joaquim","year":"2012"},{"key":"b7-focus15171","series-title":"Coluna\/Columna","first-page":"274","article-title":"Surgical management of intramedullary hemangioblastomas","volume":"8","author":"Joaquim","year":"2009"},{"key":"b8-focus15171","series-title":"Science","first-page":"1317","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993"},{"key":"b9-focus15171","series-title":"J Neurosurg","first-page":"106","article-title":"Surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau disease","volume":"98","author":"Lonser","year":"2003"},{"key":"b10-focus15171","series-title":"J Neurosurg","first-page":"523","article-title":"Intramedullary ependymoma of the spinal cord","volume":"72","author":"McCormick","year":"1990"},{"key":"b11-focus15171","series-title":"Am J Med","first-page":"595","article-title":"Lindau\u2019s disease: Review of the literature and study of a large kindred","volume":"36","author":"Melmon","year":"1964"},{"key":"b12-focus15171","series-title":"J Neurooncol","first-page":"253","article-title":"Hemangioblastomas and other uncommon intramedullary tumors","volume":"47","author":"Miller","year":"2000"},{"key":"b13-focus15171","series-title":"J Neurosurg","first-page":"24","article-title":"Hemangioblastomas of the central nervous system. 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