{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:16:09Z","timestamp":1760577369422},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>In 1955, Vincent du Vigneaud (1901\u20131978), the chairman of the Department of Biochemistry at Cornell University Medical College, was awarded the Nobel Prize for Chemistry for his research on insulin and for the first synthesis of the posterior pituitary hormones\u2014oxytocin and vasopressin. His tremendous contribution to organic chemistry, which began as an interest in sulfur-containing compounds, paved the way for a better understanding of the pituitary gland and for the development of diagnostic and therapeutic tools for diseases of the pituitary. His seminal research continues to impact neurologists, endocrinologists, and neurosurgeons, and enables them to treat patients who had no alternatives prior to du Vigneaud\u2019s breakthroughs in peptide structure and synthesis. The ability of neurosurgeons to aggressively operate on parasellar pathology was directly impacted and related to the ability to replace these hormones after surgery. The authors review the life and career of Vincent du Vigneaud, his groundbreaking discoveries, and his legacy of the understanding and treatment of the pituitary gland in health and disease.<\/jats:p>","DOI":"10.3171\/2015.5.jns141952","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T14:03:06Z","timestamp":1446213786000},"page":"1538-1542","source":"Crossref","is-referenced-by-count":4,"title":["Vincent du Vigneaud: following the sulfur trail to the discovery of the hormones of the posterior pituitary gland at Cornell Medical College"],"prefix":"10.3171","volume":"124","author":[{"given":"Malte","family":"Ottenhausen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sackler Brain and Spine Center;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imithri","family":"Bodhinayake","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sackler Brain and Spine Center;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matei A.","family":"Banu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sackler Brain and Spine Center;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"Stieg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sackler Brain and Spine Center;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sackler Brain and Spine Center;"},{"name":"Department of Otolaryngology; and"},{"name":"Department of Neuroscience, Brain and Mind Institute, Weill Medical College of Cornell University, NewYork-Presbyterian Hospital, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns141952","series-title":"J Nutr","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/jn\/112.8.1463","article-title":"Vincent du Vigneaud (1901\u20131978): a biographical sketch","volume":"112","author":"Bing","year":"1982"},{"key":"b2-jns141952","series-title":"Eur J Obstet Gynecol Reprod Biol","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S0301-2115(00)00311-0","article-title":"History and use of oxytocics","volume":"94","author":"den Hertog","year":"2001"},{"key":"b3-jns141952","series-title":"Obstet Gynecol","first-page":"363","article-title":"Vasopressin as a hemostatic in gynecologic surgery; a preliminary report","volume":"11","author":"Dillon","year":"1958"},{"key":"b4-jns141952","series-title":"A Trail of Research in Sulfur Chemistry and Metabolism, and Related Fields","author":"du Vigneaud","year":"1952"},{"key":"b5-jns141952","series-title":"Science","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1126\/science.123.3205.967","article-title":"Trail of sulfur research: from insulin to oxytocin","volume":"123","author":"du Vigneaud","year":"1956"},{"key":"b6-jns141952","series-title":"Vincent du Vigneaud 1901\u20131978","author":"Hofmann","year":"1987"},{"key":"b7-jns141952","series-title":"Am J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/0002-9378(54)90261-6","article-title":"Oxytocin and milk ejection","volume":"67","author":"Nickerson","year":"1954"},{"key":"b8-jns141952","series-title":"J Chem Educ","first-page":"8","article-title":"Interview with Vincent du Vigneaud","volume":"53","author":"Plane","year":"1973"},{"key":"b9-jns141952","series-title":"J Pept Sci","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/psc.864","article-title":"The Nobel trail of Vincent du Vigneaud","volume":"13","author":"Ragnarsson","year":"2007"},{"key":"b10-jns141952","series-title":"Mayo Clin Proc","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1016\/j.mayocp.2012.01.032","article-title":"Vincent du Vigneaud\u2014Nobel Prize in chemistry","volume":"88","author":"Shampo","year":"2013"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/124\/5\/article-p1538.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/124\/5\/article-p1538.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/124\/5\/article-p1538.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T09:56:07Z","timestamp":1709978167000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/124\/5\/article-p1538.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2015.5.jns141952","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}