{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:50:09Z","timestamp":1769500209631,"version":"3.49.0"},"reference-count":29,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>Craniopharyngiomas are associated with a high rate of recurrence. The surgical management of recurrent lesions has been among the most challenging neurosurgical procedures because of the craniopharyngioma's complex topographical relationship with surrounding structures. The aim of this study was to define the determinative role of the site of origin on the growth pattern and clinical features of recurrent craniopharyngiomas.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors performed a retrospective analysis of 52 patients who had undergone uniform treatment by a single surgeon. For each patient, data concerning symptoms and signs, imaging features, hypothalamic-pituitary function, and recurrence-free survival rate were collected.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>For children, delayed puberty was more frequent in the group with Type I (infradiaphragmatic) craniopharyngioma than in the group with Type TS (tuberoinfundibular and suprasellar extraventricular) lesions (p &lt; 0.05). For adults, blindness was more frequent in the Type I group than in the Type TS group (p &lt; 0.05). Nausea or vomiting, delayed puberty, and growth retardation were more frequent in children than in adults (p &lt; 0.05). Overall clinical outcome was good in 48.07% of the patients and poor in 51.92%. Patients with Type TS recurrent tumors had significantly worse functional outcomes and hypothalamic function than patients with the Type I recurrent tumors but better pituitary function especially in children.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The origin of recurrent craniopharyngiomas significantly affected the symptoms, signs, functional outcomes, and hypothalamic-pituitary functions of patients undergoing repeated surgery. Differences in tumor growth patterns and site of origin should be considered when one is comparing outcomes and survival across treatment paradigms in patients with recurrent craniopharyngiomas.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.6.jns141883","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T17:01:58Z","timestamp":1449853318000},"page":"24-32","source":"Crossref","is-referenced-by-count":33,"title":["Origin of craniopharyngiomas: implications for growth pattern, clinical characteristics, and outcomes of tumor recurrence"],"prefix":"10.3171","volume":"125","author":[{"given":"Yun","family":"Bao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-tao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-tao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-xiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns141883","series-title":"AJNR Am J Neuroradiol","first-page":"406","article-title":"Frontal lobe implantation of craniopharyngioma by repeated needle aspirations","volume":"9","author":"Barloon","year":"1988"},{"key":"b2-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3171\/jns.1996.85.1.0073","article-title":"Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?","volume":"85","author":"De Vile","year":"1996"},{"key":"b3-jns141883","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/00006123-200002000-00007","article-title":"Long-term outcomes for surgically resected craniopharyngiomas","volume":"46","author":"Duff","year":"2000"},{"key":"b4-jns141883","series-title":"AJNR Am J Neuroradiol","first-page":"1427","article-title":"Craniopharyngioma: radiologic and histologic findings and recurrence","volume":"17","author":"Eldevik","year":"1996"},{"key":"b5-jns141883","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3171\/2009.7.PEDS09215","article-title":"Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children","volume":"5","author":"Elliott","year":"2010"},{"key":"b6-jns141883","series-title":"Neuro Oncol","first-page":"123","article-title":"Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis","volume":"4","author":"Elmaci","year":"2002"},{"key":"b7-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3171\/jns.1999.90.2.0237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999"},{"key":"b8-jns141883","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00381-009-0917-4","article-title":"Metastatic craniopharyngioma: case report and literature review","volume":"25","author":"Frangou","year":"2009"},{"key":"b9-jns141883","series-title":"AJNR Am J Neuroradiol","first-page":"1059","article-title":"Metastatic craniopharyngioma","volume":"20","author":"Gupta","year":"1999"},{"issue":"Suppl 1","key":"b10-jns141883","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000120861","article-title":"Surgical management of craniopharyngioma","volume":"21","author":"Hoffman","year":"1994"},{"key":"b11-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3171\/jns.1992.76.1.0047","article-title":"Aggressive surgical management of craniopharyngiomas in children","volume":"76","author":"Hoffman","year":"1992"},{"key":"b12-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3171\/jns.1999.90.2.0251","article-title":"Surgical treatment of craniopharyngiomas: endocrinological results","volume":"90","author":"Honegger","year":"1999"},{"key":"b13-jns141883","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1159\/000277620","article-title":"Repeat operations in pediatric patients with recurrent craniopharyngiomas","volume":"45","author":"Jang","year":"2009"},{"key":"b14-jns141883","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The Index of ADL: a standardized measure of biological and psychosocial function","volume":"185","author":"Katz","year":"1963"},{"key":"b15-jns141883","series-title":"Clin Endocrinol (Oxf)","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1365-2265.2005.02231.x","article-title":"Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up","volume":"62","author":"Karavitaki","year":"2005"},{"key":"b16-jns141883","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s003810100458","article-title":"Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors","volume":"17","author":"Kim","year":"2001"},{"key":"b17-jns141883","series-title":"Case report J Neurosurg","first-page":"804","article-title":"Remote recurrence of craniopharyngioma in the epidural space","volume":"77","author":"Malik","year":"1992"},{"key":"b18-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3171\/jns.2005.103.2.0224","article-title":"Surgical management of the recurrence and regrowth of craniopharyngiomas","volume":"103","author":"Minamida","year":"2005"},{"key":"b19-jns141883","series-title":"Clin Endocrinol (Oxf)","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1365-2265.1995.tb02664.x","article-title":"Hypothalamic-pituitary dysfunction in patients with craniopharyngioma","volume":"42","author":"Paja","year":"1995"},{"key":"b20-jns141883","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.wneu.2012.07.033","article-title":"Predictive factors for craniopharyngioma recurrence: a systematic review and illustrative case report of a rapid recurrence","volume":"79","author":"Prieto","year":"2013"},{"key":"b21-jns141883","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00701-010-0940-y","article-title":"Anatomic relations of the arachnoidea around the pituitary stalk: relevance for surgical removal of craniopharyngiomas","volume":"153","author":"Qi","year":"2011"},{"key":"b22-jns141883","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000120827","article-title":"A critical review of personal experiences with craniopharyngioma: clinical history, surgical technique and operative results. 1983","volume":"21","author":"Raimondi","year":"1994"},{"key":"b23-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3171\/jns.1979.50.5.0617","article-title":"Craniopharyngiomas in childhood. A rational approach to treatment","volume":"50","author":"Shapiro","year":"1979"},{"key":"b24-jns141883","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000120693","article-title":"Radical resections of childhood craniopharyngiomas","volume":"19","author":"Tomita","year":"1993"},{"key":"b25-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3171\/jns.2002.97.1.0003","article-title":"Craniopharyngioma in adults and children: a study of 122 surgical cases","volume":"97","author":"Van Effenterre","year":"2002"},{"key":"b26-jns141883","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1227\/00006123-199412000-00001","article-title":"Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome","volume":"35","author":"Weiner","year":"1994"},{"issue":"Suppl 1","key":"b27-jns141883","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000120871","article-title":"Surgical management of recurrent craniopharyngiomas","volume":"21","author":"Wisoff","year":"1994"},{"key":"b28-jns141883","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3171\/jns.1990.73.1.0003","article-title":"Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients","volume":"73","author":"Ya\u015fargil","year":"1990"},{"key":"b29-jns141883","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00381-005-1201-x","article-title":"Radical resection of craniopharyngioma","volume":"21","author":"Zuccaro","year":"2005"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/125\/1\/article-p24.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/125\/1\/article-p24.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/125\/1\/article-p24.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T23:59:46Z","timestamp":1682812786000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/125\/1\/article-p24.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":29,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2015.6.jns141883","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}