{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:40:06Z","timestamp":1787503206637,"version":"build-2736575974"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>The biological origin of cerebellar liponeurocytomas is unknown, and hereditary forms of this disease have not been described. Here, the authors present clinical and histopathological findings of a young patient with a cerebellar liponeurocytoma who had multiple immediate family members who harbored similar intracranial tumors. A 37-year-old otherwise healthy woman presented with a history of progressive headaches. Lipomatous medulloblastoma had been diagnosed previously in her mother and maternal grandfather, and her maternal uncle had a supratentorial liponeurocytoma. MRI revealed a large, poorly enhancing, lipomatous mass emanating from the superior vermis that produced marked compression of posterior fossa structures. An uncomplicated supracerebellar infratentorial approach was used to resect the lesion. Genetic and histopathological analyses of the lesion revealed neuronal, glial, and lipomatous differentiation and confirmed the diagnosis of cerebellar liponeurocytoma. A comparison of the tumors resected from the patient and, 22 years previously, her mother revealed similar features. Cerebellar liponeurocytoma is a poorly understood entity. This report provides novel evidence of an inheritable predisposition for tumor development. Accurate diagnosis and reporting of clinical outcomes and associated genetic and histopathological changes are necessary for guiding prognosis and developing recommendations for patient care.<\/jats:p>","DOI":"10.3171\/2015.6.jns142965","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T09:59:35Z","timestamp":1448618375000},"page":"57-61","source":"Crossref","is-referenced-by-count":16,"title":["Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report"],"prefix":"10.3171","volume":"125","author":[{"given":"Amparo","family":"Wolf","sequence":"first","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Alghefari","sequence":"additional","affiliation":[{"name":"Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Krivosheya","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Staudt","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Bowden","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"},{"name":"Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharan","family":"Goobie","sequence":"additional","affiliation":[{"name":"Pediatrics, London Health Sciences Centre, London Regional Cancer Centre, and Western University Schulich School of Medicine and Dentistry, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew O.","family":"Hebb","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1-jns142965","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.3171\/2014.9.FOCUS14505","article-title":"Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma","volume":"37","author":"Agnihotri","year":"2014"},{"key":"b2-jns142965","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11060-004-9172-4","article-title":"Cerebellar liponeurocytoma\/lipidized medulloblastoma","volume":"71","author":"Aker","year":"2005"},{"key":"b3-jns142965","series-title":"J Neuroradiol","first-page":"121","article-title":"Cerebellar liponeurocytoma (lipomatous medulloblastoma)","volume":"30","author":"Akhaddar","year":"2003"},{"key":"b4-jns142965","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/00006123-199803000-00035","article-title":"Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: case report","volume":"42","author":"Alleyne","year":"1998"},{"key":"b5-jns142965","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s11060-012-0853-0","article-title":"FABP4 is a candidate marker of cerebellar liponeurocytomas","volume":"108","author":"Anghileri","year":"2012"},{"key":"b6-jns142965","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF00690447","article-title":"Mixed mesenchymal and neuroectodermal tumor of the cerebellum","volume":"41","author":"Bechtel","year":"1978"},{"key":"b7-jns142965","series-title":"Neuropathology","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1440-1789.2004.00574.x","article-title":"Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case","volume":"25","author":"Buccoliero","year":"2005"},{"key":"b8-jns142965","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11060-010-0361-z","article-title":"Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature","volume":"103","author":"Chakraborti","year":"2011"},{"key":"b9-jns142965","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/0046-8177(93)90113-U","article-title":"Lipidized medulloblastoma in adults","volume":"24","author":"Davis","year":"1993"},{"key":"b10-jns142965","series-title":"Neuropathol Appl Neurobiol","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2990.1993.tb00410.x","article-title":"Neurocytoma\/lipoma (neurolipocytoma) of the cerebellum","volume":"19","author":"Ellison","year":"1993"},{"key":"b11-jns142965","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/00000478-199606000-00002","article-title":"Medullocytoma (lipidized medulloblastoma). 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