{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:42:42Z","timestamp":1790196162835,"version":"4.1.0"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The authors undertook this study to validate the feasibility and safety of stereotactic radiofrequency thermocoagulation (SRT) for the surgical treatment of giant hypothalamic hamartoma (HH).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Of the 109 patients who underwent SRT for hypothalamic hamartoma (HH) at the authors' institution between 1997 and 2013, 16 patients (9 female, 7 male) had giant HHs (maximum diameter \u2265 30 mm). The clinical records of these 16 patients were retrospectively reviewed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The patients' age at first SRT ranged from 1 to 22 years (median 5 years). The maximum diameter of their HHs was 30\u201380 mm (mean 38.5 mm). Eleven HHs had bilateral attachments to the hypothalamus. All patients had gelastic seizures (GS), and 12 had types of seizures other than GS. Some of these patients also had mental retardation (n = 10, 62.5%), behavioral disorders (n = 8, 50.0%), and precocious puberty (n = 11, 68.8%). A total of 22 SRT procedures were performed; 5 patients underwent repeat SRT procedures. There was no mortality or permanent morbidity. After 17 of the 22 procedures, the patients experienced transient complications, including high fever (n = 7), hyperphagia (n = 3), hyponatremia (n = 6), disturbance of consciousness (n = 1), cyst enlargement (n = 1), and epidural hematoma (n = 1). Thirteen patients (81.3%) achieved freedom from GS after the final SRT procedure during a follow-up period ranging from 6 to 60 months (mean 23 months). Twelve patients had nongelastic seizures in addition to GS, and 7 (58.3%) of these 12 patients experienced freedom from their nongelastic seizures.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>SRT provided minimal invasiveness and excellent seizure outcomes even in patients with giant HHs. Repeat SRT is safe for residual GS. SRT is a feasible single surgical strategy for HH regardless of the tumor's size or shape.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.6.jns15200","type":"journal-article","created":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T15:00:18Z","timestamp":1451660418000},"page":"812-821","source":"Crossref","is-referenced-by-count":37,"title":["Stereotactic radiofrequency thermocoagulation for giant hypothalamic hamartoma"],"prefix":"10.3171","volume":"125","author":[{"given":"Hiroshi","family":"Shirozu","sequence":"first","affiliation":[{"name":"Department of Functional Neurosurgery and"},{"name":"Hypothalamic Hamartoma Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and"},{"name":"Hypothalamic Hamartoma Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and"},{"name":"Hypothalamic Hamartoma Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and"},{"name":"Hypothalamic Hamartoma Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and"},{"name":"Hypothalamic Hamartoma Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl","key":"b1-jns15200","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3171\/2010.8.GKS101027","article-title":"Gamma Knife surgery for hypothalamic hamartomas and epilepsy: patient selection and outcomes","volume":"113","author":"Abla","year":"2010"},{"key":"b2-jns15200","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00381-013-2022-y","article-title":"Giant hypothalamic hamartoma: case report and literature review","volume":"29","author":"Alves","year":"2013"},{"key":"b3-jns15200","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2176\/nmc.45.221","article-title":"Hypothalamic hamartoma","volume":"45","author":"Arita","year":"2005"},{"key":"b4-jns15200","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1157.1997.tb01072.x","article-title":"Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature","volume":"38","author":"Berkovic","year":"1997"},{"key":"b5-jns15200","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1046\/j.1528-1157.2003.59102.x","article-title":"Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy","volume":"44","author":"Berkovic","year":"2003"},{"key":"b6-jns15200","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10143-008-0142-8","article-title":"Stereotactic disconnection of hypothalamic hamartoma to control seizure and behavior disturbance: case report and literature review","volume":"31","author":"de Almeida","year":"2008"},{"key":"b7-jns15200","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2176\/nmc.43.61","article-title":"Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification","volume":"43","author":"Delalande","year":"2003"},{"issue":"2","key":"b8-jns15200","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2011.1.FOCUS10240","article-title":"Giant solid-cystic hypothalamic hamartoma. 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