{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:31:58Z","timestamp":1782401518904,"version":"3.54.5"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>Unruptured posterior communicating artery (PCoA) aneurysms with oculomotor nerve palsy (ONP) have a very high risk of rupture. This study investigated the hemodynamic and morphological characteristics of intracranial aneurysms with high rupture risk by analyzing PCoA aneurysms with ONP.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Fourteen unruptured PCoA aneurysms with ONP, 33 ruptured PCoA aneurysms, and 21 asymptomatic unruptured PCoA aneurysms were included in this study. The clinical, morphological, and hemodynamic characteristics were compared among the different groups.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The clinical characteristics did not differ among the 3 groups (p &gt; 0.05), whereas the morphological and hemodynamic analyses showed that size, aspect ratio, size ratio, undulation index, nonsphericity index, ellipticity index, normalized wall shear stress (WSS), and percentage of low WSS area differed significantly (p &lt; 0.05) among the 3 groups. Furthermore, multiple comparisons revealed that these parameters differed significantly between the ONP group and the asymptomatic unruptured group and between the ruptured group and the asymptomatic unruptured group, except for size, which differed significantly only between the ONP group and the asymptomatic unruptured group (p = 0.0005). No morphological or hemodynamic parameters differed between the ONP group and the ruptured group.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Unruptured PCoA aneurysms with ONP demonstrated a distinctive morphological-hemodynamic pattern that was significantly different compared with asymptomatic unruptured PCoA aneurysms and was similar to ruptured PCoA aneurysms. The larger size, more irregular shape, and lower WSS might be related to the high rupture risk of PCoA aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.6.jns15267","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T18:47:20Z","timestamp":1449254840000},"page":"264-268","source":"Crossref","is-referenced-by-count":31,"title":["Hemodynamic and morphological characteristics of unruptured posterior communicating artery aneurysms with oculomotor nerve palsy"],"prefix":"10.3171","volume":"125","author":[{"given":"Nan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Karmonik","sequence":"additional","affiliation":[{"name":"Cerebrovascular Center, Department of Neurosurgery, Houston Methodist, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns15267","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1161\/STROKEAHA.108.521617","article-title":"Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study","volume":"39","author":"Boussel","year":"2008"},{"key":"b2-jns15267","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3174\/ajnr.A2419","article-title":"Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms","volume":"32","author":"Cebral","year":"2011"},{"key":"b3-jns15267","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1227\/01.NEU.0000316847.64140.81","article-title":"Morphology parameters for intracranial aneurysm rupture risk assessment","volume":"63","author":"Dhar","year":"2008"},{"key":"b4-jns15267","series-title":"J Neurointerv Surg","article-title":"Morphological and hemodynamic analysis of posterior communicating artery aneurysms prone to rupture: a matched case-control study","author":"Duan","year":"2014"},{"key":"b5-jns15267","series-title":"Surg Neurol Int","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4103\/2152-7806.74147","article-title":"A review of the management of posterior communicating artery aneurysms in the modern era","volume":"1","author":"Golshani","year":"2010"},{"key":"b6-jns15267","series-title":"J Biomech Eng","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1115\/1.2795948","article-title":"Pulsatile flow in the human left coronary artery bifurcation: average conditions","volume":"118","author":"He","year":"1996"},{"key":"b7-jns15267","series-title":"J Neurointerv Surg","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1136\/neurintsurg-2012-010596.rep","article-title":"Computational fluid dynamics simulation of an anterior communicating artery ruptured during angiography","volume":"6","author":"Hodis","year":"2014"},{"key":"b8-jns15267","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.3174\/ajnr.A1180","article-title":"Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery","volume":"29","author":"Jou","year":"2008"},{"key":"b9-jns15267","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00701-013-1773-2","article-title":"Changes in wall shear stress magnitude after aneurysm rupture","volume":"155","author":"Kono","year":"2013"},{"key":"b10-jns15267","series-title":"Schweiz Rundsch Med Prax","first-page":"3","article-title":"[Is early diagnosis possible in cerebral aneurysm? 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