{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:49:54Z","timestamp":1792756194130,"version":"4.5.0"},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Patients with skull base (anterior and middle fossa) and convexity (anterior and posterior) meningiomas (n = 54) underwent neuropsychological examination prior to and 1 year after surgery. A control group (n = 52) of healthy volunteers matched for age, sex, and education underwent the same examination. Assessments included executive, memory, and motor functions with standardized testing. Patients with convexity meningiomas were clinically assessed for parietal association cortex functions.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>All patients performed significantly worse (p &lt; 0.05) in most neurocognitive domains than controls. The skull base group showed more disturbances in memory than the convexity group (p &lt; 0.05). The anterior convexity group showed more deficits in executive function than the posterior convexity group, which presented with parietal association cortex deficits. Verbal deficits were more pronounced in the left hemisphere than in the right hemisphere. Patients with a large tumor (&gt; 4 cm) had more severe neurocognitive deficits than those with a small tumor (&lt; 4 cm). Postoperatively, patients showed no deterioration in neurocognitive function. Instead, significant improvement (p &lt; 0.05) was observed in some executive, motor, and parietal association cortex functions.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>According to the authors\u2019 findings, intracranial meningiomas may cause neurocognitive deficits in patients. Surgery does not cause a deterioration in cognitive function; instead, it may lead to improvements in some functions. Permanent neuropsychological postoperative deficits should be interpreted as tumor-induced rather than due to surgery.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2015.6.jns1549","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:47:20Z","timestamp":1449236840000},"page":"1578-1584","source":"Crossref","is-referenced-by-count":45,"title":["Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study"],"prefix":"10.3171","volume":"124","author":[{"given":"Evangelia","family":"Liouta","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital; and"},{"name":"Hellenic Center for Neurosurgical Research \u201cProf. Petros Kokkalis,\u201d Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Koutsarnakis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidon","family":"Liakos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Stranjalis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital; and"},{"name":"Hellenic Center for Neurosurgical Research \u201cProf. Petros Kokkalis,\u201d Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns1549","series-title":"South Med J","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1097\/00007611-198108000-00022","article-title":"Frontal lobe lesions and behavior","volume":"74","author":"Andy","year":"1981"},{"key":"b2-jns1549","series-title":"Br J Psychiatry","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1192\/bjp.119.548.19","article-title":"Seven cases of frontal tumour with psychiatric presentation","volume":"119","author":"Avery","year":"1971"},{"key":"b3-jns1549","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3171\/jns.1984.60.1.0052","article-title":"Morbidity, mortality, and quality of life following surgery for intracranial meningiomas. 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