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The average age of the patients was 56.4 \u00b1 12.5 years. Seventy-nine percent of the tumors were located within the anterior skull base. Neurological examinations and neuropsychological testing were performed at 3 time points: 1 day prior to surgery (T1), 3\u20135 months after surgery (T2), and 9\u201312 months after surgery (T3). The average follow-up duration was 13.8 months. Neuropsychological assessment consisted of quality of life, depression and anxiety, verbal learning and memory, cognitive speed, attention and concentration, figural memory, and visual-motor speed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Following surgery, 23% of patients showed transient neurological deficits and 12% showed permanent new neurological deficits with varying grades of manifestation. Postoperative quality of life, however, remained stable and was slightly improved at follow-up examinations at T3 (60.6 \u00b1 21.5 vs 63.6 \u00b1 24.1 points), and there was no observed effect on anxiety and depression. Long-term verbal memory, working memory, and executive functioning were slightly affected within the first months following surgery and appeared to be the most vulnerable to impairment by the tumor or the resection but were stable or improved in the majority of patients at long-term follow-up examinations after 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This report describes the first prospective study of neuropsychological outcomes following resection of skull base meningiomas and, as such, contributes to a better understanding of postoperative impairment in these patients. Despite deterioration in a minority of patients on subscales of the measures used, the majority demonstrated stable or improved outcome at follow-up assessments.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.10.jns161936","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T15:00:31Z","timestamp":1486738831000},"page":"1242-1248","source":"Crossref","is-referenced-by-count":31,"title":["Prospective analysis of neuropsychological deficits following resection of benign skull base meningiomas"],"prefix":"10.3171","volume":"127","author":[{"given":"Klaus","family":"Zweckberger","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Giese","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Schick","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas W.","family":"Unterberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns161936","series-title":"J Natl Cancer Inst","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson NK,","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, : The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. 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