{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:24:32Z","timestamp":1794324272814,"version":"4.9.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Thyroid disorder has been known to affect vascular function and has been associated with aortic aneurysm formation in some cases; however, the connection has not been well studied. The authors hypothesized that hypothyroidism is associated with the formation of cerebral aneurysms.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The authors performed a retrospective case-control study of consecutive patients who had undergone cerebral angiography at an academic, tertiary care medical center in the period from April 2004 through April 2014. Patients with unruptured aneurysms were identified from among those who had undergone 3-vessel catheter angiography. Age-matched controls without cerebral aneurysms on angiography were also identified from the same database. Patients with previous subarachnoid hemorrhage or intracranial hemorrhage were excluded. History of hypothyroidism and other risk factors were recorded.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Two hundred forty-three patients with unruptured cerebral aneurysms were identified and age matched with 243 controls. Mean aneurysm size was 9.6 \u00b1 0.8 mm. Hypothyroidism was present in 40 patients (16.5%) and 9 matched controls (3.7%; adjusted OR 3.2, 95% CI 1.3\u20137.8, p = 0.01). Subgroup analysis showed that men with hypothyroidism had higher odds of an unruptured cerebral aneurysm diagnosis than the women with hypothyroidism, with an adjusted OR of 12.7 (95% CI 1.3\u2013121.9) versus an OR of 2.5 (95% CI 1.0\u20136.4) on multivariate analysis.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Hypothyroidism appears to be independently associated with unruptured cerebral aneurysms, with a higher effect seen in men. Given the known pathophysiological associations between hypothyroidism and vascular dysfunction, this finding warrants further exploration.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2016.10.jns161953","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T09:59:48Z","timestamp":1487325588000},"page":"511-514","source":"Crossref","is-referenced-by-count":12,"title":["Association of hypothyroidism with unruptured cerebral aneurysms: a case-control study"],"prefix":"10.3171","volume":"128","author":[{"given":"Kunakorn","family":"Atchaneeyasakul","sequence":"first","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tipirneni","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyank","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudheer","family":"Ambekar","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Snelling","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushrut","family":"Dharmadhikari","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Dong","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Guada","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Ramdas","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seemant","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep R.","family":"Yavagal","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"},{"name":"Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns161953","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/0002-9343(85)90218-9","article-title":"Risk factors for the development and rupture of intracranial berry aneurysms","volume":"78","author":"de la Monte SM,","year":"1985","unstructured":"de la Monte SM, Moore GW, Monk MA, Hutchins GM: Risk factors for the development and rupture of intracranial berry aneurysms. Am J Med 78:957\u2013964, 198510.1016\/0002-9343(85)90218-9"},{"key":"b2-jns161953","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1056\/NEJM199812103392401","article-title":"Unruptured intracranial aneurysms\u2014risk of rupture and risks of surgical intervention","volume":"339","author":"International Study of Unruptured Intracranial Aneurysms Investigators","year":"1998","unstructured":"International Study of Unruptured Intracranial Aneurysms Investigators: Unruptured intracranial aneurysms\u2014risk of rupture and risks of surgical intervention. N Engl J Med 339:1725\u20131733, 1998. (Erratum in N Engl J Med 340: 744, 1999)986755010.1056\/NEJM199812103392401"},{"key":"b3-jns161953","series-title":"Endokrinologie","first-page":"116","article-title":"The mucopolysaccharide content of the human aorta in hypothyroidism","volume":"50","author":"J\u00f3zsa L,","year":"1966","unstructured":"J\u00f3zsa L, Szederk\u00e9nyi J: The mucopolysaccharide content of the human aorta in hypothyroidism. Endokrinologie 50:116\u2013122, 19665998871"},{"key":"b4-jns161953","series-title":"J Endocrinol Invest","first-page":"96","article-title":"Endothelial dysfunction and subclinical hypothyroidism: a brief review","volume":"35","author":"La Vignera S,","year":"2012","unstructured":"La Vignera S, Condorelli R, Vicari E, Calogero AE: Endothelial dysfunction and subclinical hypothyroidism: a brief review. J Endocrinol Invest 35:96\u2013103, 2012"},{"key":"b5-jns161953","series-title":"A population-based case-control study Ann Intern Med","first-page":"168","article-title":"Subarachnoid hemorrhage and hormonal factors in women","volume":"121","author":"Longstreth WT,","year":"1994","unstructured":"Longstreth WT, Nelson LM, Koepsell TD, van Belle G: Subarachnoid hemorrhage and hormonal factors in women. A population-based case-control study Ann Intern Med 121:168\u2013173, 1994"},{"key":"b6-jns161953","series-title":"BMJ","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/bmj.4.5884.110-b","article-title":"Association between hypothyroidism and abdominal aneurysm","volume":"4","author":"Niarchos AP,","year":"1973","unstructured":"Niarchos AP, Finn R: Association between hypothyroidism and abdominal aneurysm. BMJ 4:110, 1973. (Letter)10.1136\/bmj.4.5884.110-b4745334"},{"key":"b7-jns161953","series-title":"Metabolism","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.metabol.2003.10.003","article-title":"Treating hypothyroidism improves endothelial function","volume":"53","author":"Papaioannou GI,","year":"2004","unstructured":"Papaioannou GI, Lagasse M, Mather JF, Thompson PD: Treating hypothyroidism improves endothelial function. Metabolism 53:278\u2013279, 20041501513610.1016\/j.metabol.2003.10.003"},{"key":"b8-jns161953","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review","volume":"29","author":"Rinkel GJ,","year":"1998","unstructured":"Rinkel GJ, Djibuti M, Algra A, van Gijn J: Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 29:251\u2013256, 1998944535910.1161\/01.STR.29.1.251"},{"key":"b9-jns161953","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S0140-6736(97)80009-8","article-title":"Familial intracranial aneurysms","volume":"349","author":"Ronkainen A,","year":"1997","unstructured":"Ronkainen A, Hernesniemi J, Puranen M, Niemitukia L, Vanninen R, Ryyn\u00e4nen M, : Familial intracranial aneurysms. Lancet 349:380\u2013384, 1997903346310.1016\/S0140-6736(97)80009-8"},{"key":"b10-jns161953","series-title":"Postgrad Med J","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1136\/pgmj.58.685.706","article-title":"Aortic aneurysm in a patient with long-standing hypothyroidism","volume":"58","author":"Savage C,","year":"1982","unstructured":"Savage C, Deanfield JE, Jung RT: Aortic aneurysm in a patient with long-standing hypothyroidism. Postgrad Med J 58:706\u2013707, 198210.1136\/pgmj.58.685.706"},{"key":"b11-jns161953","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"Vlak MH,","year":"2011","unstructured":"Vlak MH, Algra A, Brandenburg R, Rinkel GJ: Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 10:626\u2013636, 201110.1016\/S1474-4422(11)70109-021641282"},{"key":"b12-jns161953","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/STROKEAHA.111.000329","article-title":"Independent risk factors for intracranial aneurysms and their joint effect: a case-control study","volume":"44","author":"Vlak MH,","year":"2013","unstructured":"Vlak MH, Rinkel GJ, Greebe P, Algra A: Independent risk factors for intracranial aneurysms and their joint effect: a case-control study. Stroke 44:984\u2013987, 20132342208810.1161\/STROKEAHA.111.000329"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/128\/2\/article-p511.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/128\/2\/article-p511.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/128\/2\/article-p511.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T23:19:33Z","timestamp":1743376773000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/128\/2\/article-p511.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":12,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2016.10.jns161953","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}