{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:38:57Z","timestamp":1791815937573,"version":"4.3.4"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The goal of this study was to provide insight into the influence of gliomas on gestational outcomes, the impact of pregnancy on gliomas, and the identification of patients at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In this multiinstitutional retrospective study, the authors identified 52 pregnancies in 50 women diagnosed with a glioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>For gliomas known prior to pregnancy (n = 24), we found the following: 1) An increase in the quantified imaging growth rates occurred during pregnancy in 87% of cases. 2) Clinical deterioration occurred in 38% of cases, with seizures alone resolving after delivery in 57.2% of cases. 3) Oncological treatments were immediately performed after delivery in 25% of cases. For gliomas diagnosed during pregnancy (n = 28), we demonstrated the following: 1) The tumor was discovered during the second and third trimesters in 29% and 54% of cases, respectively, with seizures being the presenting symptom in 68% of cases. 2) The quantified imaging growth rates did not significantly decrease after delivery and before oncological treatment. 3) Clinical deterioration resolved after delivery in 21.4% of cases. 4) Oncological treatments were immediately performed after delivery in 70% of cases. Gliomas with a high grade of malignancy, negative immunoexpression of alpha-internexin, or positive immunoexpression for p53 were more likely to be associated with tumor progression during pregnancy. Deliveries were all uneventful (cesarean section in 54.5% of cases and vaginal delivery in 45.5%), and the infants were developmentally normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>When a woman harboring a glioma envisions a pregnancy, or when a glioma is discovered in a pregnant patient, the authors suggest informing her and her partner that pregnancy may impact the evolution of the glioma clinically and radiologically. They strongly advise a multidisciplinary approach to management.<\/jats:p><jats:p><jats:bold>\u25a0 CLASSIFICATION OF EVIDENCE<\/jats:bold> Type of question: association; study design: case series; evidence: Class IV.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.10.jns16710","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T14:59:15Z","timestamp":1488553155000},"page":"3-13","source":"Crossref","is-referenced-by-count":48,"title":["Interactions between glioma and pregnancy: insight from a 52-case multicenter series"],"prefix":"10.3171","volume":"128","author":[{"given":"Sophie","family":"Peeters","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sainte-Anne Hospital, Paris;"},{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris;"},{"name":"Department of Neuropathology, Sainte-Anne Hospital, Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gauchotte","sequence":"additional","affiliation":[{"name":"Department of Pathology, CHU Nancy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saint-Louis Hospital, Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Cartalat-Carel","sequence":"additional","affiliation":[{"name":"Department of Neuro-oncology, Hospices Civils de Lyon, H\u00f4pital Neurologique, Bron;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Guillamo","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Caen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Capelle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris;"},{"name":"R\u00e9seau d'Etude des Gliomes, REG, Groland; 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