{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:23:40Z","timestamp":1785410620621,"version":"3.56.0"},"reference-count":74,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The object of this study was to determine the percentage of high-dose (1800\u20132600 cGy) single-fraction stereotactic radiosurgery (SF-SRS) treatments to the spine that result in peripheral nervous system (PNS) injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>All patients treated with SF-SRS for primary or metastatic spine tumors between January 2004 and May 2013 and referred to the Rehabilitation Medicine Service for evaluation and treatment of neuromuscular, musculoskeletal, or functional impairments or pain were retrospectively identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Five hundred fifty-seven SF-SRS treatments in 447 patients resulted in 14 PNS injuries in 13 patients. All injures resulted from SF-SRS delivered to the cervical or lumbosacral spine at 2400 cGy. The overall percentage of SF-SRS treatments resulting in PNS injury was 2.5%, increasing to 4.5% when the thoracic spine was excluded from analysis. The median time to symptom onset following SF-SRS was 10 months (range 4\u201332 months). The plexus (cervical, brachial, and\/or lumbosacral) was affected clinically and\/or electrophysiologically in 12 (86%) of 14 cases, the nerve root in 2 (14%) of 14, and both in 6 (43%) of 14 cases. All patients experienced pain and most (93%) developed weakness. Peripheral nervous system injuries were CTCAE Grade 1 in 14% of cases, 2 in 64%, and 3 in 21%. No dose relationship between SF-SRS dose and PNS injury was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Single-fraction SRS to the spine can result in PNS injury with major implications for function and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2016.11.focus16348","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T03:45:07Z","timestamp":1488339907000},"page":"E12","source":"Crossref","is-referenced-by-count":44,"title":["Peripheral nervous system injury after high-dose single-fraction image-guided stereotactic radiosurgery for spine tumors"],"prefix":"10.3171","volume":"42","author":[{"given":"Michael D.","family":"Stubblefield","sequence":"first","affiliation":[{"name":"Kessler Institute for Rehabilitation Select Medical, West Orange, New Jersey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rehabilitation Medicine Service;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyn R.","family":"Riedel","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Barzilai","sequence":"additional","affiliation":[{"name":"Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Laufer","sequence":"additional","affiliation":[{"name":"Neurosurgery,"},{"name":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lis","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Bilsky","sequence":"additional","affiliation":[{"name":"Neurosurgery,"},{"name":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16348","series-title":"J Neurosurg Spine","first-page":"556","article-title":"Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma","volume":"17","author":"Balagamwala EH,","year":"2012","unstructured":"Balagamwala EH, Angelov L, Koyfman SA, Suh JH, Reddy CA, Djemil T, : Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma. 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