{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:43:04Z","timestamp":1782938584960,"version":"3.54.5"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Obesity and low-back pain associated with degenerative spondylosis or spondylolisthesis are common comorbid conditions. Many patients report that the pain and disability associated with degenerative lumbar disease are key factors in their inability to lose weight. The aim of this retrospective study was to determine if there is an association between improved functional status and weight loss following a successful transforaminal lumbar interbody fusion (TLIF) procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective cohort study of patients who underwent single-level TLIF was performed. Inclusion criteria were preoperative body mass index (BMI) greater than 30 kg\/m<jats:sup>2<\/jats:sup>, achievement of minimum clinically important difference in the Oswestry Disability Index (ODI, defined as improvement of 15 points), and minimum 1-year postoperative followup BMI. Preoperative and postoperative BMI, ODI, and visual analog scale (VAS) scores were compared. A subgroup analysis of patients who achieved substantial clinical benefit (SCB, defined as a net improvement of 18.8 points on the ODI) was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 56 patients met the inclusion criteria. The mean age of the study population was 55.6 \u00b1 13.7 years. The mean preoperative BMI was 34.8 \u00b1 4.6 kg\/m<jats:sup>2<\/jats:sup>, the mean preoperative ODI was 66.2 \u00b1 10.1, and the mean preoperative VAS score was 7.1 \u00b1 1.7. The mean change in ODI was \u221233.1 \u00b1 13.5 (p &lt; 0.01) and the mean change in the VAS score was \u22124.1 \u00b1 2.1 (p &lt; 0.01). The mean change in BMI was +0.15 \u00b1 2.1 kg\/m<jats:sup>2<\/jats:sup> (range \u22124.2 to +6.5 kg\/m<jats:sup>2<\/jats:sup>; p = 0.6). SCB was achieved in 46 patients on the ODI. The mean preoperative BMI for patients with SCB was 34.8 \u00b1 4.8 kg\/m<jats:sup>2<\/jats:sup>, and the mean postoperative BMI was 34.7 \u00b1 5.0 kg\/m<jats:sup>2<\/jats:sup>. The mean change in BMI was \u22120.03 \u00b1 1.9 kg\/m<jats:sup>2<\/jats:sup> (p = 0.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite successful surgical intervention via TLIF with achievement of improved function and pain, obese patients did not have significant change in weight postoperatively.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.11.spine16973","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T14:03:59Z","timestamp":1490969039000},"page":"705-708","source":"Crossref","is-referenced-by-count":10,"title":["Does clinical improvement of symptomatic degenerative lumbar disease impact obesity?"],"prefix":"10.3171","volume":"26","author":[{"given":"Jacob R.","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishaan","family":"Farooqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyne N.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"La Marca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine16973","series-title":"Int J Obes","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/sj.ijo.0803715","article-title":"The impact of obesity on the musculoskeletal system","volume":"32","author":"Anandacoomarasamy A,","year":"2008","unstructured":"Anandacoomarasamy A, Caterson I, Sambrook P, Fransen M, March L: The impact of obesity on the musculoskeletal system. Int J Obes 32:211\u2013222, 200810.1038\/sj.ijo.0803715"},{"key":"b2-spine16973","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0140-6736(99)01312-4","article-title":"Epidemiological features of chronic low-back pain","volume":"354","author":"Andersson GB:","year":"1999","unstructured":"Andersson GB: Epidemiological features of chronic low-back pain. Lancet 354:581\u2013585, 199910.1016\/S0140-6736(99)01312-410470716"},{"key":"b3-spine16973","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"478","DOI":"10.7326\/0003-4819-147-7-200710020-00006","article-title":"Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society","volume":"147","author":"Chou R,","year":"2007","unstructured":"Chou R, Qaseem A, Snow V, Casey D, Cross JT Jr, Shekelle P, : Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med 147:478\u2013491, 20071790920910.7326\/0003-4819-147-7-200710020-00006"},{"key":"b4-spine16973","series-title":"Spine J","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.spinee.2007.11.006","article-title":"Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales","volume":"8","author":"Copay AG,","year":"2008","unstructured":"Copay AG, Glassman SD, Subach BR, Berven S, Schuler TC, Carreon LY: Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales. Spine J 8:968\u2013974, 200810.1016\/j.spinee.2007.11.00618201937"},{"key":"b5-spine16973","series-title":"Spine J","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.spinee.2007.01.008","article-title":"Understanding the minimum clinically important difference: a review of concepts and methods","volume":"7","author":"Copay AG,","year":"2007","unstructured":"Copay AG, Subach BR, Glassman SD, Polly DW Jr, Schuler TC: Understanding the minimum clinically important difference: a review of concepts and methods. Spine J 7:541\u2013546, 200710.1016\/j.spinee.2007.01.00817448732"},{"key":"b6-spine16973","series-title":"Spine J","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.spinee.2015.02.001","article-title":"The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies","volume":"15","author":"Dario AB,","year":"2015","unstructured":"Dario AB, Ferreira ML, Refshauge KM, Lima TS, Ordo\u00f1ana JR, Ferreira PH: The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies. Spine J 15:1106\u20131117, 20152566143210.1016\/j.spinee.2015.02.001"},{"key":"b7-spine16973","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/BRS.0000000000000655","article-title":"The impact of obesity on short- and long-term outcomes after lumbar fusion","volume":"40","author":"De la Garza-Ramos R,","year":"2015","unstructured":"De la Garza-Ramos R, Bydon M, Abt NB, Sciubba DM, Wolinsky JP, Bydon A, : The impact of obesity on short- and long-term outcomes after lumbar fusion. Spine (Phila Pa 1976) 40:56\u201361, 201510.1097\/BRS.0000000000000655"},{"key":"b8-spine16973","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/00007632-200202010-00021","article-title":"Association between obesity and functional status in patients with spine disease","volume":"27","author":"Fanuele JC,","year":"2002","unstructured":"Fanuele JC, Abdu WA, Hanscom B, Weinstein JN: Association between obesity and functional status in patients with spine disease. Spine (Phila Pa 1976) 27:306\u2013312, 200210.1097\/00007632-200202010-0002111805697"},{"key":"b9-spine16973","series-title":"Orthopade","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1007\/s00132-005-0817-6","article-title":"[Obesity and low back pain\u2014biology, biomechanics and epidemiology]","volume":"34","author":"Flamme CH:","year":"2005","unstructured":"Flamme CH: [Obesity and low back pain\u2014biology, biomechanics and epidemiology]. Orthopade 34:652\u2013657, 2005. (Ger)10.1007\/s00132-005-0817-615918049"},{"key":"b10-spine16973","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"Flegal KM,","year":"2012","unstructured":"Flegal KM, Carroll MD, Kit BK, Ogden CL: Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010. JAMA 307:491\u2013497, 201210.1001\/jama.2012.3922253363"},{"key":"b11-spine16973","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.wneu.2015.06.020","article-title":"Does obesity affect outcomes after decompressive surgery for lumbar spinal stenosis? A multi-center, observational, registry-based study","volume":"84","author":"Giannadakis C,","year":"2015","unstructured":"Giannadakis C, Nerland US, Solheim O, Jakola AS, Gulati M, Weber C, : Does obesity affect outcomes after decompressive surgery for lumbar spinal stenosis? A multi-center, observational, registry-based study. World Neurosurg 84:1227\u20131234, 201510.1016\/j.wneu.2015.06.020"},{"key":"b12-spine16973","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.2106\/JBJS.G.01095","article-title":"Defining substantial clinical benefit following lumbar spine arthrodesis","volume":"90","author":"Glassman SD,","year":"2008","unstructured":"Glassman SD, Copay AG, Berven SH, Polly DW, Subach BR, Carreon LY: Defining substantial clinical benefit following lumbar spine arthrodesis. J Bone Joint Surg Am 90:1839\u20131847, 20081876264210.2106\/JBJS.G.01095"},{"key":"b13-spine16973","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/01.brs.0000250979.12398.96","article-title":"Degenerative lumbar spondylolisthesis: an epidemiological perspective: the Copenhagen Osteoarthritis Study","volume":"32","author":"Jacobsen S,","year":"2007","unstructured":"Jacobsen S, Sonne-Holm S, Rovsing H, Monrad H, Gebuhr P: Degenerative lumbar spondylolisthesis: an epidemiological perspective: the Copenhagen Osteoarthritis Study. Spine (Phila Pa 1976) 32:120\u2013125, 200710.1097\/01.brs.0000250979.12398.9617202902"},{"key":"b14-spine16973","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"586","DOI":"10.7326\/0003-4819-137-7-200210010-00010","article-title":"Diagnostic evaluation of low back pain with emphasis on imaging","volume":"137","author":"Jarvik JG,","year":"2002","unstructured":"Jarvik JG, Deyo RA: Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med 137:586\u2013597, 20021235394610.7326\/0003-4819-137-7-200210010-00010"},{"key":"b15-spine16973","series-title":"Rev Med Brux","first-page":"147","article-title":"[Evolution of low back pain after bariatric surgery.]","volume":"36","author":"Koulischer S,","year":"2015","unstructured":"Koulischer S, Cadi\u00e8re B, Cadi\u00e8re GB, Fabeck L: [Evolution of low back pain after bariatric surgery.]. Rev Med Brux 36:147\u2013151, 2015. (Fr)26372975"},{"key":"b16-spine16973","series-title":"Int J Obes Relat Metab Disord","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/sj.ijo.0802534","article-title":"Influence of weight loss on pain, perceived disability and observed functional limitations in obese women","volume":"28","author":"Larsson UE:","year":"2004","unstructured":"Larsson UE: Influence of weight loss on pain, perceived disability and observed functional limitations in obese women. Int J Obes Relat Metab Disord 28:269\u2013277, 20041461053310.1038\/sj.ijo.0802534"},{"key":"b17-spine16973","series-title":"Int J Obes Relat Metab Disord","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/sj.ijo.0801805","article-title":"Perceived disability and observed functional limitations in obese women","volume":"25","author":"Larsson UE,","year":"2001","unstructured":"Larsson UE, Mattsson E: Perceived disability and observed functional limitations in obese women. Int J Obes Relat Metab Disord 25:1705\u20131712, 200110.1038\/sj.ijo.080180511753594"},{"issue":"2","key":"b18-spine16973","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2013.5.FOCUS13154","article-title":"Comparison of perioperative outcomes following open versus minimally invasive transforaminal lumbar interbody fusion in obese patients","volume":"35","author":"Lau D,","year":"2013","unstructured":"Lau D, Khan A, Terman SW, Yee T, La Marca F, Park P: Comparison of perioperative outcomes following open versus minimally invasive transforaminal lumbar interbody fusion in obese patients. Neurosurg Focus 35:2E10, 201310.3171\/2013.5.FOCUS1315423905948"},{"key":"b19-spine16973","series-title":"Obesity (Silver Spring)","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/oby.21160","article-title":"Weight loss outcomes in patients with pain","volume":"23","author":"Masheb RM,","year":"2015","unstructured":"Masheb RM, Lutes LD, Kim HM, Holleman RG, Goodrich DE, Janney CA, : Weight loss outcomes in patients with pain. Obesity (Silver Spring) 23:1778\u20131784, 20152623711210.1002\/oby.21160"},{"key":"b20-spine16973","series-title":"Eur J Intern Med","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejim.2007.09.011","article-title":"Barriers to obesity treatment","volume":"19","author":"Mauro M,","year":"2008","unstructured":"Mauro M, Taylor V, Wharton S, Sharma AM: Barriers to obesity treatment. Eur J Intern Med 19:173\u2013180, 20081839516010.1016\/j.ejim.2007.09.011"},{"key":"b21-spine16973","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States, 2011\u20132012","volume":"311","author":"Ogden CL,","year":"2014","unstructured":"Ogden CL, Carroll MD, Kit BK, Flegal KM: Prevalence of childhood and adult obesity in the United States, 2011\u20132012. JAMA 311:806\u2013814, 201410.1001\/jama.2014.73224570244"},{"key":"b22-spine16973","series-title":"J Neurosurg Spine","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3171\/2010.12.SPINE10472","article-title":"Utility of minimum clinically important difference in assessing pain, disability, and health state after transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis","volume":"14","author":"Parker SL,","year":"2011","unstructured":"Parker SL, Adogwa O, Paul AR, Anderson WN, Aaronson O, Cheng JS, : Utility of minimum clinically important difference in assessing pain, disability, and health state after transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis. J Neurosurg Spine 14:598\u2013604, 20112133228110.3171\/2010.12.SPINE10472"},{"key":"b23-spine16973","series-title":"J Neurosurg Spine","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3171\/2014.2.SPINE13794","article-title":"Minimally invasive versus open transforaminal lumbar interbody fusion: comparison of clinical outcomes among obese patients","volume":"20","author":"Terman SW,","year":"2014","unstructured":"Terman SW, Yee TJ, Lau D, Khan AA, La Marca F, Park P: Minimally invasive versus open transforaminal lumbar interbody fusion: comparison of clinical outcomes among obese patients. J Neurosurg Spine 20:644\u2013652, 20142474535510.3171\/2014.2.SPINE13794"},{"key":"b24-spine16973","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0140-6736(11)60814-3","article-title":"Health and economic burden of the projected obesity trends in the USA and the UK","volume":"378","author":"Wang YC,","year":"2011","unstructured":"Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M: Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378:815\u2013825, 201110.1016\/S0140-6736(11)60814-321872750"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/26\/6\/article-p705.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/26\/6\/article-p705.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/26\/6\/article-p705.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T22:21:12Z","timestamp":1681597272000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/26\/6\/article-p705.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":24,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2016.11.spine16973","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}