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In this combined electrophysiology and imaging study, the authors investigated the electrophysiology within this tractography-defined VIM (T-VIM).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Thalamic neurons were classified based on their relative location to the T-VIM: dorsal, within, and ventral to the T-VIM. The authors identified the movement-responsive cells (kinesthetic and tremor cells), performed spike analysis (firing rate and burst index), and local field potential analysis (area under the curve for 13\u201330 Hz). Tremor efficacy in response to microstimulation along the electrode trajectory was also assessed in relation to the T-VIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Seventy-three cells from a total of 9 microelectrode tracks were included for this analysis. Movement-responsive cells (20 kinesthetic cells and 26 tremor cells) were identified throughout the electrode trajectories. The mean firing rate and burst index of cells (n = 27) within the T-VIM are 18.8 \u00b1 9.8 Hz and 4.5 \u00b1 5.4, respectively. Significant local field potential beta power was identified within the T-VIM (area under the curve for 13\u201330 Hz = 6.6 \u00b1 7.7) with a trend toward higher beta power in the dorsal T-VIM. The most significant reduction in tremor was also observed in the dorsal T-VIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The electrophysiological findings within the VIM thalamus defined by tractography, or T-VIM, correspond with the known microelectrode recording characteristics of the VIM in patients with tremor.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.3.jns151992","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T14:00:05Z","timestamp":1469196005000},"page":"1669-1675","source":"Crossref","is-referenced-by-count":40,"title":["Microelectrode recording findings within the tractography-defined ventral intermediate nucleus"],"prefix":"10.3171","volume":"126","author":[{"given":"Nicolas Kon Kam","family":"King","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"},{"name":"Department of Neurosurgery, National Neuroscience Institute, Singapore; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhor","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"},{"name":"Center for Neuromodulation, Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diellor","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Physiology, Toronto Western Hospital, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Elias","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Hodaie","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"},{"name":"Division of Brain Imaging, Behaviour Systems Neuroscience, Toronto Western Research Institute;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Hutchison","sequence":"additional","affiliation":[{"name":"Department of Physiology, Toronto Western Hospital, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns151992","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1227\/NEU.0b013e3181f74105","article-title":"An assessment of current brain targets for deep brain stimulation surgery with susceptibility-weighted imaging at 7 tesla","volume":"67","author":"Abosch A","year":"2010","unstructured":"Abosch A, Yacoub E, Ugurbil K, Harel N: An assessment of current brain targets for deep brain stimulation surgery with susceptibility-weighted imaging at 7 tesla. 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