{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:41:20Z","timestamp":1791650480009,"version":"4.3.4"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>OBJECT<\/jats:title><jats:p>Histopathological examination has revealed that ruptured cerebral aneurysms have different hemostatic patterns depending on the location of the clot formation. In this study, the authors investigated whether the hemostatic patterns had specific hemodynamic features using computational fluid dynamics (CFD) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty-six ruptured middle cerebral artery aneurysms were evaluated by 3D CT angiography and harvested at the time of clipping. The hemostatic patterns at the rupture points were assessed by means of histopathological examination, and morphological parameters were obtained. Transient analysis was performed, and wall shear stress\u2013related hemodynamic parameters and invariant Q (vortex core region) were calculated. The morphological and hemodynamic parameters were compared among the hemostatic patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Hematoxylin and eosin staining of the aneurysm wall showed 13 inside-pattern, 9 outside-pattern, and 4 other-pattern aneurysms. Three of the 26 aneurysms were excluded from further analysis, because their geometry models could not be generated due to low vascular CT values. Mann-Whitney U-tests showed that lower dome volume (0.04 cm<jats:sup>3<\/jats:sup> vs 0.12 cm<jats:sup>3<\/jats:sup>, p = 0.014), gradient oscillatory number (0.0234 vs 0.0289, p = 0.023), invariant Q (\u22120.801 10<jats:sup>\u22122<\/jats:sup>\/sec<jats:sup>2<\/jats:sup> vs \u22120.124 10<jats:sup>\u22122<\/jats:sup>\/sec<jats:sup>2<\/jats:sup>, p = 0.045) and higher aneurysm formation indicator (0.986 vs 0.963, p = 0.041) were significantly related to inside-pattern aneurysms when compared with outside-pattern aneurysms.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Inside-pattern aneurysms may have simpler flow patterns and less flow stagnation than outside-pattern aneurysms. CFD may be useful to characterize the hemostatic pattern of ruptured cerebral aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.3.jns152264","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T14:01:58Z","timestamp":1464962518000},"page":"1566-1572","source":"Crossref","is-referenced-by-count":28,"title":["Stagnation and complex flow in ruptured cerebral aneurysms: a possible association with hemostatic pattern"],"prefix":"10.3171","volume":"126","author":[{"given":"Masanori","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Research Institute for Brain and Blood Vessels, Akita, Akita;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujimaro","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization, Tsu, Mie; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization, Tsu, Mie; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanemura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization, Tsu, Mie; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shimosaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization, Tsu, Mie; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns152264","series-title":"Ann Biomed Eng","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1007\/s10439-013-0794-6","article-title":"Investigating the influence of haemodynamic stimuli on intracranial aneurysm inception","volume":"41","author":"Chen H","year":"2013","unstructured":"Chen H, Selimovic A, Thompson H, Chiarini A, Penrose J, Ventikos Y, : Investigating the influence of haemodynamic stimuli on intracranial aneurysm inception. 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