{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:47:16Z","timestamp":1791402436240,"version":"4.3.3"},"reference-count":44,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n OBJECTIVE<\/jats:title>\n The pathophysiological mechanisms responsible for the formation of intracranial aneurysms (IAs) remain only partially elucidated. However, current evidence suggests a genetic component. The purpose of this study was to investigate the specific anatomical variations in the arterial complex that are associated with the presence of anterior communicating artery (ACoA) aneurysms in the familial forms of IAs.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n This multicenter study investigated bifurcation IAs in patients who had a sporadic ACoA IA without a family history of IA (SACAA group), in patients who had an ACoA IA with a family history of IA (FACAA group), and in their healthy first-degree relatives (HFDRs). Through the use of MR angiography (MRA) reconstructions, the symmetry of the A\n 1<\/jats:sub>\n segments and the angle between the A\n 1<\/jats:sub>\n and A\n 2<\/jats:sub>\n segments were analyzed on 3D models for each group. These measurements were then compared among the 3 groups.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Twenty-four patients with SACAA, 24 patients with FACAA, and 20 HFDRs were included in the study. Asymmetrical configuration of the A\n 1<\/jats:sub>\n segments was more frequent in the FACAA group than in the HFDR group (p = 0.002). The aneurysm-side A\n 1<\/jats:sub>\n \u2013A\n 2<\/jats:sub>\n angle was lower in the FACAA group (p = 0.003) and SACAA group (p = 0.007) than in the HFDR group. On the contralateral side, there was no difference in A\n 1<\/jats:sub>\n \u2013A\n 2<\/jats:sub>\n angles between groups.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The anatomical shape of the ACoA complex seems to be similarly associated with the presence of ACoA IAs in both the FACAA and SACAA groups. This highlights the role played by hemodynamic constraints in aneurysm formation and questions the hypothesis of the hereditary character of these anatomical shapes.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2016.4.jns153032","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T10:01:52Z","timestamp":1466157712000},"page":"1598-1605","source":"Crossref","is-referenced-by-count":11,"title":["Is there an inherited anatomical conformation favoring aneurysmal formation of the anterior communicating artery?"],"prefix":"10.3171","volume":"126","author":[{"given":"Romain","family":"Bourcier","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Hospital Guillaume et Ren\u00e9 Laennec;"},{"name":"CNRS, UMR 6291, Universit\u00e9 de Nantes, Nantes; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lenoble","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Hospital Guillaume et Ren\u00e9 Laennec;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Guyomarch-Delasalle","sequence":"additional","affiliation":[{"name":"INSERM, UMR1087, l'institut du thorax, CHU de Nantes;"},{"name":"CNRS, UMR 6291, Universit\u00e9 de Nantes, Nantes; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Daumas-Duport","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Hospital Guillaume et Ren\u00e9 Laennec;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Papagiannaki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, CHU Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Redon","sequence":"additional","affiliation":[{"name":"INSERM, UMR1087, l'institut du thorax, CHU de Nantes;"},{"name":"CNRS, UMR 6291, Universit\u00e9 de Nantes, Nantes; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Desal","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Hospital Guillaume et Ren\u00e9 Laennec;"},{"name":"CNRS, UMR 6291, Universit\u00e9 de Nantes, Nantes; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns153032","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1001\/archneur.1978.00500340051010","article-title":"Familial incidence of ruptured intracranial aneurysms. 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