{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:01:08Z","timestamp":1789131668989,"version":"build-2803163510"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Antiepileptic drugs (AEDs) are often administered prophylactically following brain tumor resection. With conflicting evidence and unestablished guidelines, however, the nature of this practice among tumor surgeons is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>On November 24, 2015, a REDCap (Research Electronic Database Capture) survey was sent to members of the AANS\/CNS Section on Tumors to query practice patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Responses were received from 144 individuals, including 18.8% of board-certified neurosurgeons surveyed (across 86 institutions, 16 countries, and 5 continents). The majority reported practicing in an academic setting (85%) as a tumor specialist (71%). Sixty-three percent reported always or almost always prescribing AED prophylaxis postoperatively in patients with a supratentorial brain tumor without a prior seizure history. Meanwhile, 9% prescribed occasionally and 28% rarely prescribed AED prophylaxis. The most common agent was levetiracetam (85%). The duration of seizure prophylaxis varied widely: 25% of surgeons administered prophylaxis for 7 days, 16% for 2 weeks, 21% for 2 to 6 weeks, and 13% for longer than 6 weeks. Most surgeons (61%) believed that tumor pathology influences epileptogenicity, with high-grade glioma (39%), low-grade glioma (31%), and metastases (24%) carrying the greatest seizure risk. While the majority used prophylaxis, 62% did not believe or were unsure if prophylactic AEDs reduced seizures postoperatively. The vast majority (82%) stated that a well-designed randomized trial would help guide their future clinical decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Wide knowledge and practice gaps exist regarding the frequency, duration, and setting of AED prophylaxis for seizure-naive patients undergoing brain tumor resection. Acceptance of universal practice guidelines on this topic is unlikely until higher-level evidence supporting or refuting the value of modern seizure prophylaxis is demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2016.4.jns16245","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T21:03:09Z","timestamp":1466888589000},"page":"1772-1778","source":"Crossref","is-referenced-by-count":87,"title":["Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS\/CNS Section on Tumors survey"],"prefix":"10.3171","volume":"126","author":[{"given":"Michael C.","family":"Dewan","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven N.","family":"Kalkanis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Henry Ford Health System, Detroit, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred G.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Massachusetts General Hospital, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos G.","family":"Hadjipanayis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns16245","series-title":"BMC Health Serv Res","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1472-6963-3-23","article-title":"Can surveying practitioners about their practices help identify priority clinical practice guideline topics?","volume":"3","author":"Brouwers MC,","year":"2003","unstructured":"Brouwers MC, Chambers A, Perry J: Can surveying practitioners about their practices help identify priority clinical practice guideline topics?. BMC Health Serv Res 3:23, 200310.1186\/1472-6963-3-2314687426"},{"key":"b2-jns16245","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1227\/00006123-198509000-00021","article-title":"Anticonvulsant prophylaxis in neurological surgery","volume":"17","author":"Deutschman CS,","year":"1985","unstructured":"Deutschman CS, Haines SJ: Anticonvulsant prophylaxis in neurological surgery. Neurosurgery 17:510\u2013517, 198510.1227\/00006123-198509000-000212864654"},{"key":"b3-jns16245","series-title":"J Neurointerv Surg","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1136\/neurintsurg-2013-011075","article-title":"Current practice regarding seizure prophylaxis in aneurysmal subarachnoid hemorrhage across academic centers","volume":"7","author":"Dewan MC,","year":"2015","unstructured":"Dewan MC, Mocco J: Current practice regarding seizure prophylaxis in aneurysmal subarachnoid hemorrhage across academic centers. J Neurointerv Surg 7:146\u2013149, 201510.1136\/neurintsurg-2013-01107524474163"},{"key":"b4-jns16245","series-title":"J Neurosurg","article-title":"Perioperative seizure in patients with glioma is associated with longer hospitalization, higher readmission, and decreased overall survival","author":"Dewan MC,","unstructured":"Dewan MC, White-Dzuro GA, Brinson PR, Thompson RC, Chambless LB: Perioperative seizure in patients with glioma is associated with longer hospitalization, higher readmission, and decreased overall survival. J Neurosurg [epub ahead of print February 19, 2016. DOI: 10.3171\/2015.10.JNS151956]26894454"},{"key":"b5-jns16245","series-title":"J Neurosurg","article-title":"Seizures in supratentorial meningioma: a systematic review and meta-analysis","author":"Englot DJ,","unstructured":"Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW: Seizures in supratentorial meningioma: a systematic review and meta-analysis. J Neurosurg [epub ahead of print December 4, 2015. DOI: 10.3171\/2015.5.JNS15935]26636386"},{"key":"b6-jns16245","series-title":"Can J Neurol Sci","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1017\/S0317167100053361","article-title":"Prophylactic anticonvulsants in patients with brain tumour","volume":"30","author":"Forsyth PA,","year":"2003","unstructured":"Forsyth PA, Weaver S, Fulton D, Brasher PMA, Sutherland G, Stewart D, : Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 30:106\u2013112, 20031277494910.1017\/S0317167100053361"},{"key":"b7-jns16245","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF01665108","article-title":"The natural history of postoperative seizures","volume":"57","author":"Foy PM,","year":"1981","unstructured":"Foy PM, Copeland GP, Shaw MD: The natural history of postoperative seizures. Acta Neurochir (Wien) 57:15\u201322, 198110.1007\/BF01665108"},{"key":"b8-jns16245","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1212\/WNL.54.10.1886","article-title":"Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"54","author":"Glantz MJ,","year":"2000","unstructured":"Glantz MJ, Cole BF, Forsyth PA, Recht LD, Wen PY, Chamberlain MC, : Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 54:1886\u20131893, 200010.1212\/WNL.54.10.188610822423"},{"key":"b9-jns16245","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1212\/WNL.46.4.985","article-title":"A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors","volume":"46","author":"Glantz MJ,","year":"1996","unstructured":"Glantz MJ, Cole BF, Friedberg MH, Lathi E, Choy H, Furie K, : A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. Neurology 46:985\u2013991, 1996878007710.1212\/WNL.46.4.985"},{"key":"b10-jns16245","series-title":"J Biomed Inform","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris PA,","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG: Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377\u2013381, 200910.1016\/j.jbi.2008.08.01018929686"},{"key":"b11-jns16245","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jocn.2011.07.021","article-title":"Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy","volume":"19","author":"Kern K,","year":"2012","unstructured":"Kern K, Schebesch KM, Schlaier J, Hansen E, Feigl GC, Brawanski AT, : Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy. J Clin Neurosci 19:99\u2013100, 20122213381510.1016\/j.jocn.2011.07.021"},{"key":"b12-jns16245","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3171\/2011.4.JNS101585","article-title":"Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy","volume":"115","author":"Komotar RJ,","year":"2011","unstructured":"Komotar RJ, Raper DMS, Starke RM, Iorgulescu JB, Gutin PH: Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy. J Neurosurg 115:483\u2013490, 20112163969810.3171\/2011.4.JNS101585"},{"key":"b13-jns16245","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.clineuro.2015.04.010","article-title":"A meta-analysis: Do prophylactic antiepileptic drugs in patients with brain tumors decrease the incidence of seizures?","volume":"134","author":"Kong X,","year":"2015","unstructured":"Kong X, Guan J, Yang Y, Li Y, Ma W, Wang R: A meta-analysis: Do prophylactic antiepileptic drugs in patients with brain tumors decrease the incidence of seizures?. Clin Neurol Neurosurg 134:98\u2013103, 20152597800910.1016\/j.clineuro.2015.04.010"},{"key":"b14-jns16245","series-title":"Seizure","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1059-1311(96)80023-9","article-title":"Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis","volume":"5","author":"Kuijlen JM,","year":"1996","unstructured":"Kuijlen JM, Teernstra OP, Kessels AG, Herpers MJ, Beuls EA: Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis. Seizure 5:291\u2013298, 199610.1016\/S1059-1311(96)80023-98952015"},{"key":"b15-jns16245","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0090-3019(89)90067-0","article-title":"Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures","volume":"31","author":"Lee ST,","year":"1989","unstructured":"Lee ST, Lui TN, Chang CN, Cheng WC, Wang DJ, Heimburger RF, : Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surg Neurol 31:361\u2013364, 1989271130910.1016\/0090-3019(89)90067-0"},{"key":"b16-jns16245","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2176\/nmc.43.589","article-title":"Postoperative seizures: epidemiology, pathology, and prophylaxis","volume":"43","author":"Manaka S,","year":"2003","unstructured":"Manaka S, Ishijima B, Mayanagi Y: Postoperative seizures: epidemiology, pathology, and prophylaxis. Neurol Med Chir (Tokyo) 43:589\u2013600, 200310.2176\/nmc.43.589"},{"key":"b17-jns16245","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11060-009-0056-5","article-title":"The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline","volume":"96","author":"Mikkelsen T,","year":"2010","unstructured":"Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, : The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96:97\u2013102, 201010.1007\/s11060-009-0056-519957015"},{"key":"b18-jns16245","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1212\/01.wnl.0000324624.52935.46","article-title":"Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery","volume":"71","author":"Milligan TA,","year":"2008","unstructured":"Milligan TA, Hurwitz S, Bromfield EB: Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology 71:665\u2013669, 20081872559110.1212\/01.wnl.0000324624.52935.46"},{"key":"b19-jns16245","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11060-008-9595-4","article-title":"Guidelines for the treatment of newly diagnosed glioblastoma: introduction","volume":"89","author":"Olson JJ,","year":"2008","unstructured":"Olson JJ, Ryken T: Guidelines for the treatment of newly diagnosed glioblastoma: introduction. J Neurooncol 89:255\u2013258, 200810.1007\/s11060-008-9595-418498002"},{"key":"b20-jns16245","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s11060-013-1329-6","article-title":"Introduction, rationale, and methodology","volume":"118","author":"Olson JJ,","year":"2014","unstructured":"Olson JJ, Ryken TC, Kalkanis SN: Introduction, rationale, and methodology. J Neurooncol 118:429\u2013434, 20142471565510.1007\/s11060-013-1329-6"},{"key":"b21-jns16245","series-title":"Curr Opin Neurol","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/WCO.0b013e32833e996c","article-title":"Epilepsy in brain tumor patients","volume":"23","author":"Rossetti AO,","year":"2010","unstructured":"Rossetti AO, Stupp R: Epilepsy in brain tumor patients. Curr Opin Neurol 23:603\u2013609, 201010.1097\/WCO.0b013e32833e996c20733482"},{"key":"b22-jns16245","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11060-004-6912-4","article-title":"Results of a survey of neurosurgical practice patterns regarding the prophylactic use of anti-epilepsy drugs in patients with brain tumors","volume":"74","author":"Siomin V,","year":"2005","unstructured":"Siomin V, Angelov L, Li L, Vogelbaum MA: Results of a survey of neurosurgical practice patterns regarding the prophylactic use of anti-epilepsy drugs in patients with brain tumors. J Neurooncol 74:211\u2013215, 200510.1007\/s11060-004-6912-416193395"},{"key":"b23-jns16245","series-title":"Surg Pract","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/1744-1633.12102","article-title":"Risk factors for seizures and antiepileptic drug-associated adverse effects in high-grade glioma patients: A multicentre, retrospective study in Hong Kong","volume":"19","author":"Woo PYM,","year":"2015","unstructured":"Woo PYM, Chan DTM, Chan KY, Wong WK, Po YC, Kwok JCK, : Risk factors for seizures and antiepileptic drug-associated adverse effects in high-grade glioma patients: A multicentre, retrospective study in Hong Kong. Surg Pract 19:2\u20138, 201510.1111\/1744-1633.12102"},{"key":"b24-jns16245","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3171\/2012.12.JNS111970","article-title":"A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors","volume":"118","author":"Wu AS,","year":"2013","unstructured":"Wu AS, Trinh VT, Suki D, Graham S, Forman A, Weinberg JS, : A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg 118:873\u2013883, 201310.3171\/2012.12.JNS11197023394340"},{"key":"b25-jns16245","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11060-010-0235-4","article-title":"Perioperative levetiracetam for prevention of seizures in supratentorial brain tumor surgery","volume":"101","author":"Zachenhofer I,","year":"2011","unstructured":"Zachenhofer I, Donat M, Oberndorfer S, Roessler K: Perioperative levetiracetam for prevention of seizures in supratentorial brain tumor surgery. J Neurooncol 101:101\u2013106, 201110.1007\/s11060-010-0235-420526797"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/126\/6\/article-p1772.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/126\/6\/article-p1772.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/126\/6\/article-p1772.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T23:09:45Z","timestamp":1742684985000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/126\/6\/article-p1772.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":25,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2016.4.jns16245","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}