{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:31:15Z","timestamp":1788852675905,"version":"build-2803163510"},"reference-count":206,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Osteoblastomas are primary bone tumors with an affinity for the spine. They typically involve the posterior elements, although extension through the pedicles into the vertebral body is not uncommon. Histologically, they are usually indistinguishable from osteoid osteomas. However, there are different variants of osteoblastomas, with the more aggressive type causing more pronounced bone destruction, soft-tissue infiltration, and epidural extension. A bone scan is the most sensitive radiographic examination used to evaluate osteoblastomas. These osseous neoplasms usually present in the 2nd decade of life with dull aching pain, which is difficult to localize. At times, they can present with a painful scoliosis, which usually resolves if the osteoblastoma is resected in a timely fashion. Neurological manifestations such as radiculopathy or myelopathy do occur as well, most commonly when there is mass effect on nerve roots or the spinal cord itself. The mainstay of treatment involves surgical intervention. Curettage has been a surgical option, although marginal excision or wide en bloc resection are preferred options. Adjuvant radiotherapy and chemotherapy are generally not undertaken, although some have advocated their use after less aggressive surgical maneuvers or with residual tumor. In this manuscript, the authors have aimed to systematically review the literature and to put forth an extensive, comprehensive overview of this rare osseous tumor.<\/jats:p>","DOI":"10.3171\/2016.5.focus16122","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T03:37:36Z","timestamp":1470022656000},"page":"E4","source":"Crossref","is-referenced-by-count":80,"title":["Osteoblastomas of the spine: a comprehensive review"],"prefix":"10.3171","volume":"41","author":[{"given":"Michael A.","family":"Galgano","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R.","family":"Goulart","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Iwenofu","sequence":"additional","affiliation":[{"name":"Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Chin","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lavelle","sequence":"additional","affiliation":[{"name":"Orthopedics, State University of New York, Upstate Medical University, Syracuse, New York; and\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Mendel","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16122","series-title":"J Bone Joint Surg Am","first-page":"1146","article-title":"Scoliosis caused by benign osteoblastoma of the thoracic or lumbar spine","volume":"63","author":"Akbarnia","year":"1981"},{"key":"b2-focus16122","series-title":"Spine (Phila Pa 1976)","first-page":"212","article-title":"Rib osteoblastoma: a clinical manifestation","volume":"13","author":"Albi\u00f1ana","year":"1988"},{"key":"b3-focus16122","series-title":"J Pediatr Orthop","first-page":"555","article-title":"Osteoblastoma in the skeletally immature","volume":"28","author":"Arkader","year":"2008"},{"key":"b4-focus16122","series-title":"J Assoc Physicians India","first-page":"790","article-title":"Osteoblastoma. 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