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In this report, however, the authors describe a rare case of a 61-year-old woman with hyperprolactinemia, hypothyroidism, and acromegaly (elevation of insulin-like growth factor-1 [IGF-1]) with elevated growth hormone\u2013releasing hormone (GHRH) in whom an MRI demonstrated diffuse enlargement of the pituitary gland. Despite medical treatment, the patient had persistent elevation of IGF-1. She underwent a transsphenoidal biopsy, which yielded a diagnosis of DLBCL with an activated B-cell immunophenotype with somatotroph hyperplasia. After stereo-tactic radiation therapy in combination with chemotherapy, she is currently in remission from her lymphoma and has normalized IGF-1 levels without medical therapy, 8 months after her histopathological diagnosis. This is the only reported case of its kind and displays the importance of a broad differential diagnosis, multidisciplinary evaluation, and critical intraoperative decision-making when treating atypical sellar lesions.<\/jats:p>","DOI":"10.3171\/2016.5.jns16828","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T18:26:49Z","timestamp":1471026409000},"page":"1725-1730","source":"Crossref","is-referenced-by-count":25,"title":["Primary pituitary diffuse large B-cell lymphoma with somatotroph hyperplasia and acromegaly: case report"],"prefix":"10.3171","volume":"126","author":[{"given":"Vijay M.","family":"Ravindra","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center and Huntsman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol","family":"Raheja","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center and Huntsman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Corn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine","family":"Welt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra L.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Couldwell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center and Huntsman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns16828","series-title":"Med Pediatr Oncol","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/(SICI)1096-911X(199704)28:4<255::AID-MPO3>3.0.CO;2-H","article-title":"Intracranial Hodgkin's disease in two patients with familial Hodgkin's disease","volume":"28","author":"Ashigbi MY","year":"1997","unstructured":"Ashigbi MY, Venkatraj U, Agarwal V, Bello J, Wiernik PH: Intracranial Hodgkin's disease in two patients with familial Hodgkin's disease. 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