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More than 20 previously described morphological and physiological parameters were derived to assess quantitatively the impact of surgery. Postsurgical clinical outcomes were assessed in 2 ways, based on resolution of the patient's chief complaint and using a modified Chicago Chiari Outcome Scale (CCOS). Statistical analyses were performed to identify measures that were different between the unfavorable- and favorable-outcome cohorts. Multivariate analysis was used to identify the strongest predictors of outcome.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The strongest physiological parameter predictive of outcome was the preoperative maximal cord displacement in the upper cervical region during the cardiac cycle, which was significantly larger in the favorable-outcome subcohorts for both outcome types (p &lt; 0.05). Several hydrodynamic measures revealed significantly larger preoperative-to-postoperative changes in the favorable-outcome subcohort. Predictor sets for the chief-complaint classification included the cord displacement, percent venous drainage through the jugular veins, and normalized cerebral blood flow with 93.3% accuracy. Maximal cord displacement combined with intracranial volume change predicted outcome based on the modified CCOS classification with similar accuracy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Tested physiological measures were stronger predictors of outcome than the morphological measures in patients with CM-I. Maximal cord displacement and intracranial volume change during the cardiac cycle together with a measure that reflects the cerebral venous drainage pathway emerged as likely predictors of decompression outcome in patients with CM-I.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.5.spine1621","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T14:11:33Z","timestamp":1470406293000},"page":"28-38","source":"Crossref","is-referenced-by-count":33,"title":["Magnetic resonance imaging\u2013based measures predictive of short-term surgical outcome in patients with Chiari malformation Type I: a pilot study"],"prefix":"10.3171","volume":"26","author":[{"given":"Noam","family":"Alperin","sequence":"first","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Ryan","family":"Loftus","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet M.","family":"Bagci","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Oliu","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barth A.","family":"Green","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine1621","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1227\/NEU.0b013e31823200a6","article-title":"A novel scoring system for assessing Chiari malformation type I treatment outcomes","volume":"70","author":"Aliaga L,","year":"2012","unstructured":"Aliaga L, Hekman KE, Yassari R, Straus D, Luther G, Chen J, : A novel scoring system for assessing Chiari malformation type I treatment outcomes. 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