{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:37:11Z","timestamp":1783777031279,"version":"3.55.0"},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Laser ablation is a novel, minimally invasive procedure that utilizes MRI-guided thermal energy to treat epileptogenic and other brain lesions. In addition to treatment of mesial temporal lobe epilepsy, laser ablation is increasingly being used to target deep or inoperable lesions, including hypothalamic hamartoma (HH), subependymal giant cell astrocytoma (SEGA), and exophytic intrinsic hypothalamic\/third ventricular tumors. The authors reviewed their early institutional experience with these patients to characterize clinical outcomes in patients undergoing this procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective cohort (n = 12) of patients undergoing laser ablation at a single institution was identified, and clinical and radiographic records were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Laser ablation was successfully performed in all patients. No permanent neurological or endocrine complications occurred; 2 (17%) patients developed acute obstructive hydrocephalus or shunt malfunction following treatment. Laser ablation of HH resulted in seizure freedom (Engel Class I) in 67%, with the remaining patients having a clinically significant reduction in seizure frequency of greater than 90% compared with preoperative baseline (Engel Class IIB). Treatment of SEGAs resulted in durable clinical and radiographic tumor control in 2 of 3 cases, with one patient receiving adjuvant everolimus and the other receiving no additional therapy. Palliative ablation of hypothalamic\/third ventricular tumors resulted in partial tumor control in 1 of 3 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Early experience suggests that laser ablation is a generally safe, durable, and effective treatment for patients harboring HHs. It also appears effective for local control of SEGAs, especially in combination therapy with everolimus. Its use as a palliative treatment for intrinsic hypothalamic\/deep intraventricular tumors was less successful and associated with a higher risk of serious complications. Additional experience and long-term follow-up will be beneficial in further characterizing the effectiveness and risk profile of laser ablation in treating these lesions in comparison with conventional resective surgery or stereotactic radiosurgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2016.7.focus16236","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T03:37:26Z","timestamp":1475293046000},"page":"E10","source":"Crossref","is-referenced-by-count":56,"title":["Stereotactic laser ablation for hypothalamic and deep intraventricular lesions"],"prefix":"10.3171","volume":"41","author":[{"given":"Robert T.","family":"Buckley","sequence":"first","affiliation":[{"name":"Divisions of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Divisions of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Novotny","sequence":"additional","affiliation":[{"name":"Divisions of Neurological Surgery and"},{"name":"Pediatric Neurology, Seattle Children's Hospital; and"},{"name":"Department of Neurology, University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Ojemann","sequence":"additional","affiliation":[{"name":"Divisions of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16236","series-title":"Childs Nerv Syst","first-page":"963","article-title":"Advances in the management of subependymal giant cell astrocytoma","volume":"28","author":"Beaumont","year":"2012"},{"key":"b2-focus16236","series-title":"Neurosurg Clin N Am","first-page":"69","article-title":"Laser ablation in pediatric epilepsy","volume":"27","author":"Buckley","year":"2016"},{"key":"b3-focus16236","series-title":"Lasers Surg Med","first-page":"361","article-title":"MR-guided laser-induced thermal therapy (LITT) for recurrent glioblastomas","volume":"44","author":"Carpentier","year":"2012"},{"key":"b4-focus16236","series-title":"Lasers Surg Med","first-page":"943","article-title":"Laser thermal therapy: real-time MRI-guided and computer-controlled procedures for metastatic brain tumors","volume":"43","author":"Carpentier","year":"2011"},{"key":"b5-focus16236","series-title":"Epilepsy Behav","first-page":"408","article-title":"MR-guided stereotactic laser ablation of epileptogenic foci in children","volume":"24","author":"Curry","year":"2012"},{"key":"b6-focus16236","series-title":"Epilepsia","first-page":"101","article-title":"Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy","volume":"56","author":"Drane","year":"2015"},{"key":"b7-focus16236","series-title":"Epilepsy Res","first-page":"547","article-title":"Stereotactic laser ablation of epileptogenic periventricular nodular heterotopia","volume":"108","author":"Esquenazi","year":"2014"},{"key":"b8-focus16236","series-title":"Epileptic Disord","first-page":"257","article-title":"Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy","volume":"5","author":"Harvey","year":"2003"},{"key":"b9-focus16236","series-title":"Stereotact Funct Neurosurg","first-page":"397","article-title":"Laser ablation as treatment strategy for medically refractory dominant insular epilepsy: therapeutic and functional considerations","volume":"92","author":"Hawasli","year":"2014"},{"issue":"1 Suppl Operative","key":"b10-focus16236","series-title":"Neurosurgery","first-page":"133","article-title":"Magnetic resonance thermometry-guided laser-induced thermal therapy for intracranial neoplasms: initial experience","volume":"71","author":"Jethwa","year":"2012"},{"key":"b11-focus16236","series-title":"J Neurosurg","first-page":"1503","article-title":"MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas","volume":"124","author":"Kameyama","year":"2016"},{"key":"b12-focus16236","series-title":"Lasers Surg Med","first-page":"41","article-title":"Thermal therapy of canine cerebral tumors using a 980 nm diode laser with MR temperature-sensitive imaging feedback","volume":"35","author":"Kangasniemi","year":"2004"},{"key":"b13-focus16236","series-title":"Neurology","first-page":"574","article-title":"Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma","volume":"80","author":"Krueger","year":"2013"},{"issue":"6","key":"b14-focus16236","series-title":"Neurosurg Focus","first-page":"E7","article-title":"Hypothalamic hamartomas. 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