{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:56:10Z","timestamp":1781909770916,"version":"3.54.5"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>In this study the authors evaluated whether extracranial-intracranial bypass surgery can prevent stroke occurrence and decrease mortality in adult patients with symptomatic moyamoya disease (MMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The medical records of 249 consecutive adult patients with symptomatic MMD that was confirmed by digital subtraction angiography between 2002 and 2011 at 8 institutions were retrospectively reviewed. The study outcomes of stroke recurrence as a primary event and death during the 6-year follow-up and perioperative complications within 30 days as secondary events were compared between the bypass and medical treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The bypass group comprised 158 (63.5%) patients, and the medical treatment group comprised 91 (36.5%) patients. For 249 adult patients with MMD, bypass surgery showed an HR of 0.48 (95% CI 0.27\u20130.86, p = 0.014) for stroke recurrence calculated by Cox regression analysis. However, for the 153 patients with ischemic MMD, the HR of bypass surgery for stroke recurrence was 1.07 (95% CI 0.43\u20132.66, p = 0.887). For the 96 patients with hemorrhagic MMD, the multivariable adjusted HR of bypass surgery for stroke recurrence was 0.18 (95% CI 0.06\u20130.49, p = 0.001). For the treatment modality, indirect bypass and direct bypass (or combined bypass) did not show any significant difference for stroke recurrence, perioperative stroke, or mortality (log rank; p = 0.524, p = 0.828, and p = 0.616, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>During the treatment of symptomatic MMD in adults, bypass surgery reduces stroke recurrence for the hemorrhagic type, but it does not do so for the ischemic type. The best choice of bypass methods in adult patients with MMD is uncertain. In adult ischemic MMD, a prospective randomized study to evaluate the effectiveness and safety of bypass surgery to prevent recurrent stroke is necessary.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.8.jns152875","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T14:59:53Z","timestamp":1478876393000},"page":"492-502","source":"Crossref","is-referenced-by-count":59,"title":["Bypass surgery versus medical treatment for symptomatic moyamoya disease in adults"],"prefix":"10.3171","volume":"127","author":[{"given":"Dong-Kyu","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Kyun","family":"Rha","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Youido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil-Woo","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ho","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik Seong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Geun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hoon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns152875","series-title":"Neurosurgery","first-page":"430","article-title":"Surgical outcomes for moyamoya angiopathy at barrow neurological institute with comparison of adult indirect encephaloduroarteriosynangiosis bypass, adult direct superficial temporal artery-to-middle cerebral artery bypass, and pediatric bypass: 154 revascularization surgeries in 140 affected hemispheres","volume":"73","author":"Abla AA,","year":"2013","unstructured":"Abla AA, Gandhoke G, Clark JC, Oppenlander ME, Velat GJ, Zabramski JM, : Surgical outcomes for moyamoya angiopathy at barrow neurological institute with comparison of adult indirect encephaloduroarteriosynangiosis bypass, adult direct superficial temporal artery-to-middle cerebral artery bypass, and pediatric bypass: 154 revascularization surgeries in 140 affected hemispheres. 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