{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:42:40Z","timestamp":1790055760443,"version":"4.0.1"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The study aimed to assess the diagnostic accuracy of 320-detector row nonsubtracted and subtracted volume CT angiography (VCTA) in detecting small cerebral aneurysms (&lt; 3 mm) compared with 3D digital subtraction angiography (3D DSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Six hundred sixty-two patients underwent 320-detector row VCTA and 3D DSA for suspected cerebral aneurysms. Five neuroradiologists independently reviewed VCTA and 3D DSA images. The 3D DSA was considered the reference standard, and the sensitivity, specificity, and accuracy of nonsubtracted and subtracted VCTA in depicting small aneurysms were analyzed. A p value &lt; 0.05 was considered a significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>According to 3D DSA images, 98 small cerebral aneurysms were identified in 90 of 662 patients. Nonsubtracted VCTA depicted 90 small aneurysms. Ten small aneurysms were missed, and 2 small aneurysms were misdiagnosed. The missed small aneurysms were located almost in the internal carotid artery, near bone tissue. The sensitivity, specificity, and accuracy of nonsubtracted VCTA in depicting small aneurysms were 89.8%, 99.2%, and 96.5%, respectively, on a per-aneurysm basis. Subtracted VCTA depicted 97 small aneurysms. Three small aneurysms were missed, and 2 small aneurysms were misdiagnosed. The sensitivity, specificity, and accuracy of subtracted VCTA in depicting small aneurysms were 96.9%, 99.2%, and 98.6%, respectively, on a per-aneurysm basis. There was no difference in accuracy between subtracted VCTA and 3D DSA (p = 1.000). However, nonsubtracted VCTA had significantly less sensitivity than 3D DSA and subtracted VCTA (p = 0.039 and 0.016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Subtracted 320-detector row VCTA is sensitive enough to replace 3D DSA in the diagnosis of small cerebral aneurysms (&lt; 3 mm). The accuracy rate of nonsubtracted VCTA was lower than that of subtracted VCTA and 3D DSA, especially in the assessment of small internal carotid artery aneurysms adjacent to the skull base.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.8.jns16238","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T13:59:42Z","timestamp":1478267982000},"page":"725-731","source":"Crossref","is-referenced-by-count":12,"title":["Accuracy of 320-detector row nonsubtracted and subtracted volume CT angiography in evaluating small cerebral aneurysms"],"prefix":"10.3171","volume":"127","author":[{"given":"Wenhua","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Interventional Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"He","sequence":"additional","affiliation":[{"name":"Departments of Interventional Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Peng","sequence":"additional","affiliation":[{"name":"Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caoye","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Interventional Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Interventional Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns16238","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1227\/01.NEU.0000369512.58898.99","article-title":"Trends in case-fatality rates in hospitalized nontraumatic subarachnoid hemorrhage: results of a population-based study in Dijon, France, from 1985 to 2006","volume":"66","author":"Biotti D,","year":"2010","unstructured":"Biotti D, Jacquin A, Boutarbouch M, Bousquet O, Durier J, Ben Salem D, : Trends in case-fatality rates in hospitalized nontraumatic subarachnoid hemorrhage: results of a population-based study in Dijon, France, from 1985 to 2006. Neurosurgery 66:1039\u20131043, 2010. (Erratum in Neurosurgery 67: E878, 2010)10.1227\/01.NEU.0000369512.58898.9920386139"},{"key":"b2-jns16238","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.surneu.2007.08.005","article-title":"Accuracy of 16-row multislice computerized tomography angiography for assessment of intracranial aneurysms","volume":"71","author":"Chen W,","year":"2009","unstructured":"Chen W, Wang J, Xing W, Xu Q, Qiu J, Huang Q, : Accuracy of 16-row multislice computerized tomography angiography for assessment of intracranial aneurysms. Surg Neurol 71:32\u201342, 20091893031110.1016\/j.surneu.2007.08.005"},{"key":"b3-jns16238","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1148\/radiol.13130191","article-title":"Cerebral aneurysms: accuracy of 320-detector row nonsubtracted and subtracted volumetric CT angiography for diagnosis","volume":"269","author":"Chen W,","year":"2013","unstructured":"Chen W, Xing W, Peng Y, He Z, Wang C, Wang Q: Cerebral aneurysms: accuracy of 320-detector row nonsubtracted and subtracted volumetric CT angiography for diagnosis. Radiology 269:841\u2013849, 20132400935310.1148\/radiol.13130191"},{"key":"b4-jns16238","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.clineuro.2010.04.022","article-title":"Application of multislice computed tomographic angiography in diagnosis and treatment of intracranial aneurysms","volume":"112","author":"Chen W,","year":"2010","unstructured":"Chen W, Yang Y, Xing W, Qiu J, Peng Y: Application of multislice computed tomographic angiography in diagnosis and treatment of intracranial aneurysms. Clin Neurol Neurosurg 112:563\u2013571, 201010.1016\/j.clineuro.2010.04.02220510501"},{"key":"b5-jns16238","series-title":"Clin Neuroradiol","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00062-013-0236-8","article-title":"Detection of pulsation in unruptured cerebral aneurysms by ECG-gated 3D-CT angiography (4D-CTA) with 320-row area detector CT (ADCT) and follow-up evaluation results: assessment based on heart rate at the time of scanning","volume":"24","author":"Hayakawa M,","year":"2014","unstructured":"Hayakawa M, Tanaka T, Sadato A, Adachi K, Ito K, Hattori N, : Detection of pulsation in unruptured cerebral aneurysms by ECG-gated 3D-CT angiography (4D-CTA) with 320-row area detector CT (ADCT) and follow-up evaluation results: assessment based on heart rate at the time of scanning. Clin Neuroradiol 24:145\u2013150, 201410.1007\/s00062-013-0236-8"},{"key":"b6-jns16238","series-title":"Jpn J Radiol","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s11604-013-0228-2","article-title":"Can sufficient preoperative information of intracranial aneurysms be obtained by using 320-row detector CT angiography alone?","volume":"31","author":"Hayashida E,","year":"2013","unstructured":"Hayashida E, Sasao A, Hirai T, Hamasaki K, Nishi T, Utsunomiya D, : Can sufficient preoperative information of intracranial aneurysms be obtained by using 320-row detector CT angiography alone?. Jpn J Radiol 31:600\u2013607, 20132377169610.1007\/s11604-013-0228-2"},{"key":"b7-jns16238","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/RCT.0000000000000246","article-title":"320-row multidetector computed tomographic angiogram in the evaluation of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a pilot study","volume":"39","author":"H\u00e9bert J,","year":"2015","unstructured":"H\u00e9bert J, Roncarolo F, Tampieri D, Cortes MD: 320-row multidetector computed tomographic angiogram in the evaluation of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a pilot study. J Comput Assist Tomogr 39:541\u2013546, 201510.1097\/RCT.000000000000024626182224"},{"key":"b8-jns16238","series-title":"AJNR Am J Neuroradiol","first-page":"1199","article-title":"Comparison of three-dimensional rotational angiography with digital subtraction angiography in the assessment of ruptured cerebral aneurysms","volume":"23","author":"Hochmuth A,","year":"2002","unstructured":"Hochmuth A, Spetzger U, Schumacher M: Comparison of three-dimensional rotational angiography with digital subtraction angiography in the assessment of ruptured cerebral aneurysms. AJNR Am J Neuroradiol 23:1199\u20131205, 200212169480"},{"key":"b9-jns16238","series-title":"Jpn J Radiol","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11604-015-0429-y","article-title":"Can CT angiography reconstructed from CT perfusion source data on a 320-section volume CT scanner replace conventional CT angiography for the evaluation of intracranial arteries?","volume":"33","author":"Kidoh M,","year":"2015","unstructured":"Kidoh M, Hirai T, Oda S, Utsunomiya D, Kawano T, Yano S, : Can CT angiography reconstructed from CT perfusion source data on a 320-section volume CT scanner replace conventional CT angiography for the evaluation of intracranial arteries?. Jpn J Radiol 33:353\u2013359, 201510.1007\/s11604-015-0429-y25952405"},{"key":"b10-jns16238","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1080\/028418500127345299","article-title":"Neurologic complications of cerebral angiography. A retrospective study of complication rate and patient risk factors","volume":"41","author":"Leffers AM,","year":"2000","unstructured":"Leffers AM, Wagner A: Neurologic complications of cerebral angiography. A retrospective study of complication rate and patient risk factors. Acta Radiol 41:204\u2013210, 20001086607210.1080\/028418500127345299"},{"key":"b11-jns16238","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1148\/radiol.2523081911","article-title":"Evaluation of 64-section CT angiography for detection and treatment planning of intracranial aneurysms by using DSA and surgical findings","volume":"252","author":"Li Q,","year":"2009","unstructured":"Li Q, Lv F, Li Y, Luo T, Li K, Xie P: Evaluation of 64-section CT angiography for detection and treatment planning of intracranial aneurysms by using DSA and surgical findings. Radiology 252:808\u2013815, 200910.1148\/radiol.252308191119508992"},{"key":"b12-jns16238","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1177\/0284185113506138","article-title":"64-section multidetector CT angiography for evaluation of intracranial aneurysms: comparison with 3D rotational angiography","volume":"55","author":"Li Q,","year":"2014","unstructured":"Li Q, Lv F, Yao G, Li Y, Xie P: 64-section multidetector CT angiography for evaluation of intracranial aneurysms: comparison with 3D rotational angiography. Acta Radiol 55:840\u2013846, 201410.1177\/028418511350613824065201"},{"key":"b13-jns16238","series-title":"Yonsei Med J","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3349\/ymj.2015.56.2.403","article-title":"Incidence and risk factors for rebleeding during cerebral angiography for ruptured intracranial aneurysms","volume":"56","author":"Lim YC,","year":"2015","unstructured":"Lim YC, Kim CH, Kim YB, Joo JY, Shin YS, Chung J: Incidence and risk factors for rebleeding during cerebral angiography for ruptured intracranial aneurysms. Yonsei Med J 56:403\u2013409, 20152568398810.3349\/ymj.2015.56.2.403"},{"key":"b14-jns16238","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1148\/radiol.11110486","article-title":"Digital subtraction CT angiography for detection of intracranial aneurysms: comparison with three-dimensional digital subtraction angiography","volume":"262","author":"Lu L,","year":"2012","unstructured":"Lu L, Zhang LJ, Poon CS, Wu SY, Zhou CS, Luo S, : Digital subtraction CT angiography for detection of intracranial aneurysms: comparison with three-dimensional digital subtraction angiography. Radiology 262:605\u2013612, 201210.1148\/radiol.1111048622143927"},{"key":"b15-jns16238","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ejrad.2011.05.003","article-title":"Comparison of the accuracy of subtraction CT angiography performed on 320-detector row volume CT with conventional CT angiography for diagnosis of intracranial aneurysms","volume":"81","author":"Luo Z,","year":"2012","unstructured":"Luo Z, Wang D, Sun X, Zhang T, Liu F, Dong D, : Comparison of the accuracy of subtraction CT angiography performed on 320-detector row volume CT with conventional CT angiography for diagnosis of intracranial aneurysms. Eur J Radiol 81:118\u2013122, 20122163219310.1016\/j.ejrad.2011.05.003"},{"key":"b16-jns16238","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3174\/ajnr.A0848","article-title":"Detection of aneurysms by 64-section multidetector CT angiography in patients acutely suspected of having an intracranial aneurysm and comparison with digital subtraction and 3D rotational angiography","volume":"29","author":"McKinney AM,","year":"2008","unstructured":"McKinney AM, Palmer CS, Truwit CL, Karagulle A, Teksam M: Detection of aneurysms by 64-section multidetector CT angiography in patients acutely suspected of having an intracranial aneurysm and comparison with digital subtraction and 3D rotational angiography. AJNR Am J Neuroradiol 29:594\u2013602, 200810.3174\/ajnr.A084818065510"},{"key":"b17-jns16238","series-title":"Neurointervention","doi-asserted-by":"publisher","first-page":"73","DOI":"10.5469\/neuroint.2013.8.2.73","article-title":"Clinical and radiologic results of endovascular coil embolization for cerebral aneurysm in young patients","volume":"8","author":"Park HS,","year":"2013","unstructured":"Park HS, Kwon SC, Shin SH, Park ES, Sim HB, Lyo IU: Clinical and radiologic results of endovascular coil embolization for cerebral aneurysm in young patients. Neurointervention 8:73\u201379, 201310.5469\/neuroint.2013.8.2.7324024070"},{"key":"b18-jns16238","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejrad.2007.02.018","article-title":"Detection of intracranial aneurysms with 64 channel multidetector row computed tomography: comparison with digital subtraction angiography","volume":"64","author":"Pozzi-Mucelli F,","year":"2007","unstructured":"Pozzi-Mucelli F, Bruni S, Doddi M, Calgaro A, Braini M, Cova M: Detection of intracranial aneurysms with 64 channel multidetector row computed tomography: comparison with digital subtraction angiography. Eur J Radiol 64:15\u201326, 20071741254410.1016\/j.ejrad.2007.02.018"},{"key":"b19-jns16238","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2176\/nmc.53.381","article-title":"Risk factors of ischemic lesions related to cerebral angiography and neuro-interventional procedures","volume":"53","author":"Sato M,","year":"2013","unstructured":"Sato M, Nakai Y, Tsurushima H, Shiigai M, Masumoto T, Matsumura A: Risk factors of ischemic lesions related to cerebral angiography and neuro-interventional procedures. Neurol Med Chir (Tokyo) 53:381\u2013387, 201310.2176\/nmc.53.381"},{"key":"b20-jns16238","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1056\/NEJMra052732","article-title":"Aneurysmal subarachnoid hemorrhage","volume":"354","author":"Suarez JI,","year":"2006","unstructured":"Suarez JI, Tarr RW, Selman WR: Aneurysmal subarachnoid hemorrhage. N Engl J Med 354:387\u2013396, 200610.1056\/NEJMra05273216436770"},{"key":"b21-jns16238","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.ejrad.2004.05.002","article-title":"Multislice CT angiography of small cerebral aneurysms: is the direction of aneurysm important in diagnosis?","volume":"53","author":"Teksam M,","year":"2005","unstructured":"Teksam M, McKinney A, Cakir B, Truwit CL: Multislice CT angiography of small cerebral aneurysms: is the direction of aneurysm important in diagnosis?. Eur J Radiol 53:454\u2013462, 200510.1016\/j.ejrad.2004.05.002"},{"key":"b22-jns16238","series-title":"Am J Epidemiol","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/oxfordjournals.aje.a117356","article-title":"Methods of reporting statistical results from medical research studies","volume":"141","author":"Walter SD:","year":"1995","unstructured":"Walter SD: Methods of reporting statistical results from medical research studies. Am J Epidemiol 141:896\u2013906, 1995774111910.1093\/oxfordjournals.aje.a117356"},{"key":"b23-jns16238","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1148\/radiol.2272012071","article-title":"Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature","volume":"227","author":"Willinsky RA,","year":"2003","unstructured":"Willinsky RA, Taylor SM, TerBrugge K, Farb RI, Tomlinson G, Montanera W: Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. Radiology 227:522\u2013528, 200310.1148\/radiol.227201207112637677"},{"key":"b24-jns16238","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3171\/jns.2003.98.4.0828","article-title":"Multislice computerized tomography angiography in the evaluation of intracranial aneurysms: a comparison with intraarterial digital subtraction angiography","volume":"98","author":"Wintermark M,","year":"2003","unstructured":"Wintermark M, Uske A, Chalaron M, Regli L, Maeder P, Meuli R, : Multislice computerized tomography angiography in the evaluation of intracranial aneurysms: a comparison with intraarterial digital subtraction angiography. J Neurosurg 98:828\u2013836, 20031269140910.3171\/jns.2003.98.4.0828"},{"key":"b25-jns16238","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.wneu.2011.01.046","article-title":"Sixty-four-row multislice computed tomographic angiography in the diagnosis and characterization of intracranial aneurysms: comparison with 3D rotational angiography","volume":"76","author":"Xing W,","year":"2011","unstructured":"Xing W, Chen W, Sheng J, Peng Y, Lu J, Wu X, : Sixty-four-row multislice computed tomographic angiography in the diagnosis and characterization of intracranial aneurysms: comparison with 3D rotational angiography. World Neurosurg 76:105\u2013113, 20112183996110.1016\/j.wneu.2011.01.046"},{"key":"b26-jns16238","series-title":"AJNR Am J Neuroradiol","first-page":"60","article-title":"Detection and characterization of intracranial aneurysms with 16-channel multidetector row CT angiography: a prospective comparison of volume-rendered images and digital subtraction angiography","volume":"28","author":"Yoon DY,","year":"2007","unstructured":"Yoon DY, Lim KJ, Choi CS, Cho BM, Oh SM, Chang SK: Detection and characterization of intracranial aneurysms with 16-channel multidetector row CT angiography: a prospective comparison of volume-rendered images and digital subtraction angiography. AJNR Am J Neuroradiol 28:60\u201367, 200717213425"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/4\/article-p725.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/4\/article-p725.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/4\/article-p725.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T02:09:35Z","timestamp":1742695775000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/4\/article-p725.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2016.8.jns16238","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}