{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:54:13Z","timestamp":1762955653125,"version":"3.40.2"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Delayed cerebral ischemia (DCI) causing cerebral infarction remains a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Early brain injury in the first 72 hours following rupture is likely to play a key role in the pathophysiology underlying DCI but remains difficult to quantify objectively. Current diagnostic modalities are based on the concept of vasoconstriction causing cerebral ischemia and infarction and are either invasive or have a steep learning curve and user variability. The authors sought to determine whether saccadic eye movements are impaired following aSAH and whether this measurement in the acute period is associated with the likelihood of developing DCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>As part of a prospective, observational cohort study, 24 male and female patients (mean age 53 years old, range 31\u201370 years old) were recruited. Inclusion criteria included presentation with World Federation of Neurosurgical Societies (WFNS) Grades 1 or 2 (\u201cgood grade\u201d) aSAH on admission and endovascular treatment within 72 hours of aneurysmal rupture. DCI and DCI-related cerebral infarction were defined according to consensus guidelines. Saccadometry data were collected at 3 time points in patients: in the first 72 hours, between Days 5 and 10, and at 3 months after aSAH. Data from 10 healthy controls was collected on 1 occasion for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Age-adjusted saccadic latency in patients was significantly prolonged in the first 72 hours following aSAH when compared with controls (188.7 msec [95% CI 176.9\u2013202.2 msec] vs 160.7 msec [95% CI 145.6\u2013179.4 msec], respectively; p = 0.0054, t-test). By 3 months after aSAH, there was no significant difference in median saccadic latency compared with controls (188.7 msec [95% CI 176.9\u2013202.2 msec] vs 180.0 msec [95% CI 165.1\u2013197.8 msec], respectively; p = 0.4175, t-test). Patients diagnosed with cerebral infarction due to DCI had a significantly higher age-adjusted saccadic latency in the first 72 hours than those without infarction (240.6 msec [95% CI 216.7\u2013270.3 msec] vs 204.1 msec [95% CI 190.7\u2013219.5 msec], respectively; p = 0.0157, t-test). This difference was more pronounced during Days 5\u201310 following aSAH, the peak incidence for DCI (303.7 msec [95% CI 266.7\u2013352.7 msec] vs 207.6 msec [95% CI 193.7\u2013223.6 msec], respectively; p &lt; 0.0001, t-test). A binary generalized linear model showed that latency in the first 72 hours was the only significant predictor of cerebral infarction (p = 0.0185).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This is the first study to use saccadometry to measure the saccadic latency of eye movements in patients with aSAH during the acute period following aneurysm rupture. The results showed that median saccadic latency is associated with the risk of developing cerebral infarction due to DCI and may act as a potential objective biomarker to guide the need for intensive care admission and treatment. Future studies will look to formally validate saccadic latency as a biomarker of DCI in a larger cohort and assess whether the addition of saccades improves current clinical models for predicting patients at risk.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.8.jns16408","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T15:21:45Z","timestamp":1481296905000},"page":"754-760","source":"Crossref","is-referenced-by-count":6,"title":["Acute impairment of saccadic eye movements is associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"],"prefix":"10.3171","volume":"127","author":[{"given":"Matthew J.","family":"Rowland","sequence":"first","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford; and"},{"name":"Neurosciences Intensive Care Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payashi","family":"Garry","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford; and"},{"name":"Neurosciences Intensive Care Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford; and"},{"name":"Neurosciences Intensive Care Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufus","family":"Corkill","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystalina A.","family":"Antoniades","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle T. S.","family":"Pattinson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford; and"},{"name":"Neurosciences Intensive Care Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns16408","series-title":"Neuroreport","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/WNR.0b013e32821c560d","article-title":"Saccadometry: a new tool for evaluating presymptomatic Huntington patients","volume":"18","author":"Antoniades CA,","year":"2007","unstructured":"Antoniades CA, Altham PME, Mason SL, Barker RA, Carpenter R: Saccadometry: a new tool for evaluating presymptomatic Huntington patients. Neuroreport 18:1133\u20131136, 20071758931310.1097\/WNR.0b013e32821c560d"},{"key":"b2-jns16408","series-title":"Eye (Lond)","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/eye.2014.276","article-title":"Ocular motor abnormalities in neurodegenerative disorders","volume":"29","author":"Antoniades CA,","year":"2015","unstructured":"Antoniades CA, Kennard C: Ocular motor abnormalities in neurodegenerative disorders. Eye (Lond) 29:200\u2013207, 201510.1038\/eye.2014.276"},{"key":"b3-jns16408","series-title":"J Neurosci","doi-asserted-by":"publisher","first-page":"13043","DOI":"10.1523\/JNEUROSCI.2317-15.2015","article-title":"Pallidal deep brain stimulation improves higher control of the oculomotor system in Parkinson's disease","volume":"35","author":"Antoniades CA,","year":"2015","unstructured":"Antoniades CA, Rebelo P, Kennard C, Aziz TZ, Green AL, FitzGerald JJ: Pallidal deep brain stimulation improves higher control of the oculomotor system in Parkinson's disease. J Neurosci 35:13043\u201313052, 20152640093510.1523\/JNEUROSCI.2317-15.2015"},{"key":"b4-jns16408","series-title":"J Neurol","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1007\/s00415-010-5632-2","article-title":"Huntington's disease: changes in saccades and hand-tapping over 3 years","volume":"257","author":"Antoniades CA,","year":"2010","unstructured":"Antoniades CA, Xu Z, Mason SL, Carpenter RHS, Barker RA: Huntington's disease: changes in saccades and hand-tapping over 3 years. J Neurol 257:1890\u20131898, 201010.1007\/s00415-010-5632-220585954"},{"key":"b5-jns16408","series-title":"J Neurosci","doi-asserted-by":"publisher","first-page":"13442","DOI":"10.1523\/JNEUROSCI.1163-11.2011","article-title":"Default mode network connectivity predicts sustained attention deficits after traumatic brain injury","volume":"31","author":"Bonnelle V,","year":"2011","unstructured":"Bonnelle V, Leech R, Kinnunen KM, Ham TE, Beckmann CF, De Boissezon X, : Default mode network connectivity predicts sustained attention deficits after traumatic brain injury. J Neurosci 31:13442\u201313451, 20112194043710.1523\/JNEUROSCI.1163-11.2011"},{"key":"b6-jns16408","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/sj.jcbfm.9600283","article-title":"Mechanisms of early brain injury after subarachnoid hemorrhage.","volume":"26","author":"Cahill J,","year":"2006","unstructured":"Cahill J, Calvert JW, Zhang JH: Mechanisms of early brain injury after subarachnoid hemorrhage.. J Cereb Blood Flow Metab 26:1341\u20131353, 2006. (Erratum in J Cereb Blood Flow Metab 26: 1463, 2006)10.1038\/sj.jcbfm.960028316482081"},{"key":"b7-jns16408","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1148\/radiol.2442061028","article-title":"Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans","volume":"244","author":"Camargo ECS,","year":"2007","unstructured":"Camargo ECS, Furie KL, Singhal AB, Roccatagliata L, Cunnane ME, Halpern EF, : Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans. Radiology 244:541\u2013548, 200710.1148\/radiol.244206102817581888"},{"key":"b8-jns16408","series-title":"Curr Opin Crit Care","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/00075198-200204000-00007","article-title":"Therapeutic approaches to vasospasm in subarachnoid hemorrhage","volume":"8","author":"Dorsch NWC:","year":"2002","unstructured":"Dorsch NWC: Therapeutic approaches to vasospasm in subarachnoid hemorrhage. Curr Opin Crit Care 8:128\u2013133, 20021238651310.1097\/00075198-200204000-00007"},{"key":"b9-jns16408","series-title":"Psychophysiology","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/1469-8986.00063","article-title":"Reliability of smooth pursuit, fixation, and saccadic eye movements","volume":"40","author":"Ettinger U,","year":"2003","unstructured":"Ettinger U, Kumari V, Crawford TJ, Davis RE, Sharma T, Corr PJ: Reliability of smooth pursuit, fixation, and saccadic eye movements. Psychophysiology 40:620\u2013628, 20031457016910.1111\/1469-8986.00063"},{"key":"b10-jns16408","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1161\/STROKEAHA.108.544700","article-title":"Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?","volume":"40","author":"Frontera JA,","year":"2009","unstructured":"Frontera JA, Fernandez A, Schmidt JM, Claassen J, Wartenberg KE, Badjatia N, : Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?. Stroke 40:1963\u20131968, 200910.1161\/STROKEAHA.108.54470019359629"},{"key":"b11-jns16408","series-title":"Prog Brain Res","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0079-6123(02)40067-2","article-title":"Saccade sequences as markers for cerebral dysfunction following mild closed head injury","volume":"140","author":"Heitger MH,","year":"2002","unstructured":"Heitger MH, Anderson TJ, Jones RD: Saccade sequences as markers for cerebral dysfunction following mild closed head injury. Prog Brain Res 140:433\u2013448, 20021250860710.1016\/S0079-6123(02)40067-2"},{"key":"b12-jns16408","series-title":"Brain","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1093\/brain\/awp181","article-title":"Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability","volume":"132","author":"Heitger MH,","year":"2009","unstructured":"Heitger MH, Jones RD, Macleod AD, Snell DL, Frampton CM, Anderson TJ: Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain 132:2850\u20132870, 200910.1093\/brain\/awp181"},{"key":"b13-jns16408","series-title":"Physiol Rev","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1152\/physrev.2000.80.3.953","article-title":"Role of the basal ganglia in the control of purposive saccadic eye movements","volume":"80","author":"Hikosaka O,","year":"2000","unstructured":"Hikosaka O, Takikawa Y, Kawagoe R: Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 80:953\u2013978, 200010.1152\/physrev.2000.80.3.95310893428"},{"key":"b14-jns16408","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Jauch EC,","year":"2013","unstructured":"Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJB, Demaerschalk BM, : Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 44:870\u2013947, 20132337020510.1161\/STR.0b013e318284056a"},{"key":"b15-jns16408","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3171\/jns.1990.73.1.0018","article-title":"The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results","volume":"73","author":"Kassell NF,","year":"1990","unstructured":"Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL: The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg 73:18\u201336, 199010.3171\/jns.1990.73.1.0018"},{"key":"b16-jns16408","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3171\/2015.4.JNS15428","article-title":"Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis","volume":"124","author":"Kumar G,","year":"2016","unstructured":"Kumar G, Shahripour RB, Harrigan MR: Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Neurosurg 124:1257\u20131264, 201610.3171\/2015.4.JNS1542826495942"},{"key":"b17-jns16408","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF01794677","article-title":"Cranial nerve lesions following subarachnoid hemorrhage and aneurysm of the circle of Willis","volume":"11","author":"Laun A,","year":"1988","unstructured":"Laun A, Tonn JC: Cranial nerve lesions following subarachnoid hemorrhage and aneurysm of the circle of Willis. Neurosurg Rev 11:137\u2013141, 198810.1007\/BF017946773244411"},{"key":"b18-jns16408","series-title":"Brain","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/brain\/awh035","article-title":"Using saccades as a research tool in the clinical neurosciences","volume":"127","author":"Leigh RJ,","year":"2004","unstructured":"Leigh RJ, Kennard C: Using saccades as a research tool in the clinical neurosciences. Brain 127:460\u2013477, 20041460778710.1093\/brain\/awh035"},{"key":"b19-jns16408","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1080\/02688690802710668","article-title":"The Fisher grading correlated to outcome in patients with subarachnoid haemorrhage","volume":"23","author":"Lindvall P,","year":"2009","unstructured":"Lindvall P, Runnerstam M, Birgander R, Koskinen LOD: The Fisher grading correlated to outcome in patients with subarachnoid haemorrhage. Br J Neurosurg 23:188\u2013192, 20091930617610.1080\/02688690802710668"},{"key":"b20-jns16408","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/bja\/aeh205","article-title":"Transcranial Doppler ultrasonography in anaesthesia and intensive care","volume":"93","author":"Moppett IK,","year":"2004","unstructured":"Moppett IK, Mahajan RP: Transcranial Doppler ultrasonography in anaesthesia and intensive care. Br J Anaesth 93:710\u2013724, 200410.1093\/bja\/aeh20515220174"},{"key":"b21-jns16408","series-title":"Brain Cogn","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.bandc.2008.08.018","article-title":"Neurophysiology and neuroanatomy of reflexive and volitional saccades as revealed by lesion studies with neurological patients and transcranial magnetic stimulation (TMS)","volume":"68","author":"M\u00fcri RM,","year":"2008","unstructured":"M\u00fcri RM, Nyffeler T: Neurophysiology and neuroanatomy of reflexive and volitional saccades as revealed by lesion studies with neurological patients and transcranial magnetic stimulation (TMS). Brain Cogn 68:284\u2013292, 20081884537310.1016\/j.bandc.2008.08.018"},{"key":"b22-jns16408","series-title":"Am J Electroneurodiagn Technol","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/1086508X.2009.11079700","article-title":"Transcranial Doppler series part II: performing a transcranial Doppler","volume":"49","author":"Nicoletto HA,","year":"2009","unstructured":"Nicoletto HA, Burkman MH: Transcranial Doppler series part II: performing a transcranial Doppler. Am J Electroneurodiagn Technol 49:14\u201327, 200910.1080\/1086508X.2009.11079700"},{"key":"b23-jns16408","series-title":"Modelling and Measurement in Medicine","first-page":"187","article-title":"Hand-held system for ambulatory measurement of saccadic durations of neurological patients","author":"Ober JK,","year":"2003","unstructured":"Ober JK, Przedpelska-Ober E, Gryncewicz W, Dylak J, Carpenter R, Ober JJ, Hand-held system for ambulatory measurement of saccadic durations of neurological patients. Gajda J: Modelling and Measurement in Medicine Warsaw, PAN, 2003. 187\u2013198"},{"key":"b24-jns16408","series-title":"Br J Sports Med","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/bjsm.2007.036731","article-title":"Saccadometry: the possible application of latency distribution measurement for monitoring concussion","volume":"41","author":"Pearson BC,","year":"2007","unstructured":"Pearson BC, Armitage KR, Horner CWM, Carpenter RHS: Saccadometry: the possible application of latency distribution measurement for monitoring concussion. Br J Sports Med 41:610\u2013612, 20071749606410.1136\/bjsm.2007.036731"},{"key":"b25-jns16408","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/bja\/aes264","article-title":"Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm","volume":"109","author":"Rowland MJ,","year":"2012","unstructured":"Rowland MJ, Hadjipavlou G, Kelly M, Westbrook J, Pattinson KTS: Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm. Br J Anaesth 109:315\u2013329, 201210.1093\/bja\/aes26422879655"},{"key":"b26-jns16408","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1161\/STROKEAHA.111.639906","article-title":"Multimodal monitoring in subarachnoid hemorrhage","volume":"43","author":"Sandsmark DK,","year":"2012","unstructured":"Sandsmark DK, Kumar MA, Park S, Levine JM: Multimodal monitoring in subarachnoid hemorrhage. Stroke 43:1440\u20131445, 20122242646610.1161\/STROKEAHA.111.639906"},{"key":"b27-jns16408","series-title":"Exp Brain Res","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00221-008-1569-4","article-title":"Cortical and cerebellar activation induced by reflexive and voluntary saccades","volume":"192","author":"Schraa-Tam CKL,","year":"2009","unstructured":"Schraa-Tam CKL, van Broekhoven P, van der Geest JN, Frens MA, Smits M, van der Lugt A: Cortical and cerebellar activation induced by reflexive and voluntary saccades. Exp Brain Res 192:175\u2013187, 200910.1007\/s00221-008-1569-418797855"},{"key":"b28-jns16408","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1179\/016164106X114991","article-title":"Mechanisms of acute brain injury after subarachnoid hemorrhage","volume":"28","author":"Sehba FA,","year":"2006","unstructured":"Sehba FA, Bederson JB: Mechanisms of acute brain injury after subarachnoid hemorrhage. Neurol Res 28:381\u2013398, 20061675944210.1179\/016164106X114991"},{"key":"b29-jns16408","series-title":"Prog Neurobiol","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pneurobio.2012.02.003","article-title":"The importance of early brain injury after subarachnoid hemorrhage","volume":"97","author":"Sehba FA,","year":"2012","unstructured":"Sehba FA, Hou J, Pluta RM, Zhang JH: The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol 97:14\u201337, 20122241489310.1016\/j.pneurobio.2012.02.003"},{"key":"b30-jns16408","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1212\/WNL.57.11.2105","article-title":"Cerebellar lesions impair rapid saccade amplitude adaptation","volume":"57","author":"Straube A,","year":"2001","unstructured":"Straube A, Deubel H, Ditterich J, Eggert T: Cerebellar lesions impair rapid saccade amplitude adaptation. Neurology 57:2105\u20132108, 20011173983410.1212\/WNL.57.11.2105"},{"issue":"Suppl 2","key":"b31-jns16408","series-title":"J Neurochem","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1471-4159.2012.07942.x","article-title":"Transcranial Doppler ultrasound in neurovascular diseases: diagnostic and therapeutic aspects","volume":"123","author":"Topcuoglu MA:","year":"2012","unstructured":"Topcuoglu MA: Transcranial Doppler ultrasound in neurovascular diseases: diagnostic and therapeutic aspects. J Neurochem 123:Suppl 239\u201351, 201210.1111\/j.1471-4159.2012.07942.x23050641"},{"key":"b32-jns16408","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","article-title":"Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group","volume":"41","author":"Vergouwen MDI,","year":"2010","unstructured":"Vergouwen MDI, Vermeulen M, van Gijn J, Rinkel GJE, Wijdicks EF, Muizelaar JP, : Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke 41:2391\u20132395, 20102079837010.1161\/STROKEAHA.110.589275"},{"key":"b33-jns16408","series-title":"Brain","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/brain\/115.4.1125","article-title":"Enduring dysmetria and impaired gain adaptivity of saccadic eye movements in Wallenberg's lateral medullary syndrome","volume":"115","author":"Waespe W,","year":"1992","unstructured":"Waespe W, Baumgartner R: Enduring dysmetria and impaired gain adaptivity of saccadic eye movements in Wallenberg's lateral medullary syndrome. Brain 115:1123\u20131146, 1992139350710.1093\/brain\/115.4.1125"},{"key":"b34-jns16408","series-title":"Sleep","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1093\/sleep\/28.9.1109","article-title":"Differential effects of sleep deprivation on saccadic eye movements","volume":"28","author":"Zils E,","year":"2005","unstructured":"Zils E, Sprenger A, Heide W, Born J, Gais S: Differential effects of sleep deprivation on saccadic eye movements. Sleep 28:1109\u20131115, 200510.1093\/sleep\/28.9.110916268380"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/4\/article-p754.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/4\/article-p754.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/4\/article-p754.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T02:09:13Z","timestamp":1742695753000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/4\/article-p754.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":34,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2016.8.jns16408","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"type":"print","value":"0022-3085"},{"type":"electronic","value":"1933-0693"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}