{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:33Z","timestamp":1790262153811,"version":"4.1.0"},"reference-count":78,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The authors compared clinical and radiological outcomes after resection of midline craniopharyngiomas via an endoscopic endonasal approach (EEA) versus an open transcranial approach (TCA) at a single institution in a series in which the tumors were selected to be equally amenable to gross-total resection (GTR) with either approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A single-institution retrospective review of previously untreated adult midline craniopharyngiomas was performed. Lesions were evaluated by 4 neurosurgeons blinded to the actual approach used to identify cases that were equally amenable to GTR using either an EEA or TCA. Radiological and clinical outcome data were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty-six cases amenable to either approach were identified, 21 EEA and 5 TCA. Cases involving tumors that were resected via a TCA had a trend toward larger diameter (p = 0.10) but were otherwise equivalent in preoperative clinical and radiological characteristics. GTR was achieved in a greater proportion of cases removed with an EEA than a TCA (90% vs 40%, respectively; p = 0.009). Endoscopic resection was associated with superior visual restoration (63% vs 0%; p &lt; 0.05), a decreased incidence of recurrence (p &lt; 0.001), lower increase in FLAIR signal postoperatively (\u22120.16 \u00b1 4.6 cm\n                      <jats:sup>3<\/jats:sup>\n                      vs 14.4 \u00b1 14.0 cm\n                      <jats:sup>3<\/jats:sup>\n                      ; p &lt; 0.001), and fewer complications (20% vs 80% of patients; p &lt; 0.001). Significantly more TCA patients suffered postoperative cognitive loss (80% vs 0; p &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>An EEA is a safe and effective approach to suprasellar craniopharyngiomas amenable to GTR. For this select group of cases, the EEA may provide higher rates of GTR and visual improvement with fewer complications compared with a TCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2016.9.focus16299","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:37:19Z","timestamp":1480563439000},"page":"E7","source":"Crossref","is-referenced-by-count":121,"title":["Endoscopic endonasal versus open transcranial resection of craniopharyngiomas: a case-matched single-institution analysis"],"prefix":"10.3171","volume":"41","author":[{"given":"Nelson","family":"Moussazadeh","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishaal","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan D.","family":"Bander","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Cusic","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos John","family":"Tsiouris","sequence":"additional","affiliation":[{"name":"Radiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Anand","sequence":"additional","affiliation":[{"name":"Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"},{"name":"Otolaryngology,"},{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16299","series-title":"J Natl Cancer Inst","first-page":"djv310","article-title":"Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy.","volume":"108","author":"Brastianos","year":"2015"},{"key":"b2-focus16299","series-title":"Nat Genet","first-page":"161","article-title":"Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas","volume":"46","author":"Brastianos","year":"2014"},{"key":"b3-focus16299","series-title":"J Neurosurg","first-page":"547","article-title":"The descriptive epidemiology of craniopharyngioma","volume":"89","author":"Bunin","year":"1998"},{"issue":"6 Suppl 3","key":"b4-focus16299","series-title":"Neurosurgery","first-page":"1202","article-title":"Extended endoscopic endonasal transsphenoidal approach to the suprasellar area: anatomic considerations\u2014part 1","volume":"62","author":"Cavallo","year":"2008"},{"key":"b5-focus16299","series-title":"J Neurosurg","first-page":"578","article-title":"Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas","volume":"111","author":"Cavallo","year":"2009"},{"key":"b6-focus16299","series-title":"J Neurosurg","first-page":"73","article-title":"Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?","volume":"85","author":"De Vile","year":"1996"},{"key":"b7-focus16299","series-title":"Neurosurgery","first-page":"677","article-title":"Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions: indications and limitations","volume":"64","author":"Dehdashti","year":"2009"},{"key":"b8-focus16299","series-title":"J Neurosurg","article-title":"Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas.","author":"Dhandapani"},{"key":"b9-focus16299","series-title":"World Neurosurg","first-page":"454","article-title":"Microsurgical management of craniopharyngiomas via a unilateral subfrontal approach: a retrospective study of 177 continuous cases","volume":"90","author":"Du","year":"2016"},{"key":"b10-focus16299","series-title":"Neurosurgery","first-page":"630","article-title":"Surgical management of craniopharyngiomas in children: meta-analysis and comparison of transcranial and transsphenoidal approaches","volume":"69","author":"Elliott","year":"2011"},{"key":"b11-focus16299","series-title":"J Neurosurg","first-page":"237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999"},{"key":"b12-focus16299","series-title":"J Neurosurg","first-page":"559","article-title":"Microsurgical resection of extensive craniopharyngiomas using a frontolateral approach: operative technique and 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A rational approach to treatment","volume":"50","author":"Shapiro","year":"1979"},{"key":"b30-focus16299","series-title":"J Neurosurg Sci","first-page":"454","article-title":"The endoscopic endonasal approach for the management of craniopharyngiomas","volume":"60","author":"Solari","year":"2016"},{"key":"b31-focus16299","series-title":"Childs Nerv Syst","first-page":"729","article-title":"Craniopharyngiomas in children: surgical experience at Children's Memorial Hospital","volume":"21","author":"Tomita","year":"2005"},{"key":"b32-focus16299","series-title":"J Neurosurg","first-page":"3","article-title":"Craniopharyngioma in adults and children: a study of 122 surgical cases","volume":"97","author":"Van Effenterre","year":"2002"},{"key":"b33-focus16299","series-title":"Neurosurgery","first-page":"1001","article-title":"Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome","volume":"35","author":"Weiner","year":"1994"},{"key":"b34-focus16299","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1313","article-title":"The role of radiation therapy in the management of childhood craniopharyngioma","volume":"17","author":"Weiss","year":"1989"},{"issue":"4","key":"b35-focus16299","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Craniopharyngioma: a comparison of tumor control with various treatment strategies","volume":"28","author":"Yang","year":"2010"},{"key":"b36-focus16299","series-title":"J Neurosurg","first-page":"3","article-title":"Total removal of craniopharyngiomas. 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mutant papillary craniopharyngioma to targeted therapy.","volume":"108","author":"Brastianos","year":"2015"},{"key":"b2-focus16299","series-title":"Nat Genet","first-page":"161","article-title":"Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas","volume":"46","author":"Brastianos","year":"2014"},{"key":"b3-focus16299","series-title":"J Neurosurg","first-page":"547","article-title":"The descriptive epidemiology of craniopharyngioma","volume":"89","author":"Bunin","year":"1998"},{"issue":"6 Suppl 3","key":"b4-focus16299","series-title":"Neurosurgery","first-page":"1202","article-title":"Extended endoscopic endonasal transsphenoidal approach to the suprasellar area: anatomic considerations\u2014part 1","volume":"62","author":"Cavallo","year":"2008"},{"key":"b5-focus16299","series-title":"J Neurosurg","first-page":"578","article-title":"Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas","volume":"111","author":"Cavallo","year":"2009"},{"key":"b6-focus16299","series-title":"J Neurosurg","first-page":"73","article-title":"Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?","volume":"85","author":"De Vile","year":"1996"},{"key":"b7-focus16299","series-title":"Neurosurgery","first-page":"677","article-title":"Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions: indications and limitations","volume":"64","author":"Dehdashti","year":"2009"},{"key":"b8-focus16299","series-title":"J Neurosurg","article-title":"Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas.","author":"Dhandapani"},{"key":"b9-focus16299","series-title":"World Neurosurg","first-page":"454","article-title":"Microsurgical management of craniopharyngiomas via a unilateral subfrontal approach: a retrospective study of 177 continuous cases","volume":"90","author":"Du","year":"2016"},{"key":"b10-focus16299","series-title":"Neurosurgery","first-page":"630","article-title":"Surgical management of craniopharyngiomas in children: meta-analysis and comparison of transcranial and transsphenoidal approaches","volume":"69","author":"Elliott","year":"2011"},{"key":"b11-focus16299","series-title":"J Neurosurg","first-page":"237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999"},{"key":"b12-focus16299","series-title":"J Neurosurg","first-page":"559","article-title":"Microsurgical resection of extensive craniopharyngiomas using a frontolateral approach: operative technique and outcome","volume":"120","author":"Gerganov","year":"2014"},{"key":"b13-focus16299","series-title":"J Neurosurg","first-page":"373","article-title":"Results after treatment of craniopharyngiomas: further experiences with 73 patients since 1997","volume":"116","author":"Hofmann","year":"2012"},{"key":"b14-focus16299","series-title":"J Neurosurg","first-page":"47","article-title":"Aggressive surgical management of craniopharyngiomas in children","volume":"76","author":"Hoffman","year":"1992"},{"key":"b15-focus16299","series-title":"Pituitary","first-page":"323","article-title":"Craniopharyngioma","volume":"9","author":"Jane","year":"2006"},{"key":"b16-focus16299","series-title":"Endocr Rev","first-page":"371","article-title":"Craniopharyngiomas","volume":"27","author":"Karavitaki","year":"2006"},{"key":"b17-focus16299","series-title":"Acta Neurochir (Wien)","first-page":"1917","article-title":"Extended endoscopic endonasal approach for recurrent or residual adult craniopharyngiomas","volume":"156","author":"Kim","year":"2014"},{"key":"b18-focus16299","series-title":"Childs Nerv Syst","first-page":"531","article-title":"Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic 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