{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:44Z","timestamp":1792665944396,"version":"4.5.0"},"reference-count":62,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n OBJECTIVE<\/jats:title>\n One of the more serious risks in the treatment of third ventricle craniopharyngiomas is represented by hypothalamic damage. Recently, many papers have reported the expansion of the indications for the endoscopic endonasal approach (EEA) to be used for these tumors as well. The aim of this study was to assess the outcome of sleep-wake cycle and body core temperature (BCT), both depending on hypothalamic control, in patients affected by craniopharyngiomas involving the third ventricle that were surgically treated via an EEA.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n All consecutive adult patients with craniopharyngiomas that were treated at one center via an EEA between 2014 and 2016 were prospectively included. Each patient underwent neuroradiological, endocrinological, and ophthalmological evaluation; 24-hour monitoring of the BCT rhythm; and the sleep-wake cycle before surgery and at follow-up of at least 6 months.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Ten patients were included in the study (male\/female ratio 4:6, mean age 48.6 years, SD 15.9 years). Gross-total resection was achieved in 8 cases. Preoperative BCT rhythm was pathological in 6 patients. After surgery, these disturbances resolved in 2 cases, improved in another 3, and remained the same in 1 patient; also, 1 case of de novo onset was observed. Before surgery the sleep-wake cycle was pathological in 8 cases, and it was restored in 4 patients at follow-up. After surgery the number of patients reporting diurnal naps increased from 7 to 9.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The outcome of the sleep-wake cycle and BCT analyzed after EEA in this study is promising. Despite the short duration of the authors' experience, they consider these results encouraging; additional series are needed to confirm the preliminary findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2016.9.focus16317","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:37:19Z","timestamp":1480563439000},"page":"E12","source":"Crossref","is-referenced-by-count":29,"title":["Postoperative outcome of body core temperature rhythm and sleep-wake cycle in third ventricle craniopharyngiomas"],"prefix":"10.3171","volume":"41","author":[{"given":"Matteo","family":"Zoli","sequence":"first","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Sambati","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna;"},{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Milanese","sequence":"additional","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna;"},{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Faustini-Fustini","sequence":"additional","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Marucci","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Bellaria Hospital, University of Bologna;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"de Biase","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biotechnology, University of Bologna;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tallini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Anatomic Pathology\u2013Molecular Diagnostic Unit, Azienda Sanitaria Locale of Bologna, University of Bologna School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annagrazia","family":"Cecere","sequence":"additional","affiliation":[{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mignani","sequence":"additional","affiliation":[{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Sturiale","sequence":"additional","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Frank","sequence":"additional","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Ear, Nose and Throat Department, Bellaria Hospital, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cortelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna;"},{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mazzatenta","sequence":"additional","affiliation":[{"name":"Center of Surgery for Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Provini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna;"},{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16317","series-title":"J Clin Neurosci","first-page":"850","article-title":"Immediate postoperative death due to hypothalamic injury following surgery for craniopharyngioma","volume":"16","author":"Bahuleyan","year":"2009"},{"key":"b2-focus16317","series-title":"Neurosurg Clin N Am","first-page":"363","article-title":"Endoscopic endonasal approach for craniopharyngiomas","volume":"26","author":"Baldauf","year":"2015"},{"key":"b3-focus16317","series-title":"J Neurosurg","first-page":"100","article-title":"The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients","volume":"121","author":"Cavallo","year":"2014"},{"key":"b4-focus16317","series-title":"Neurosurg Rev","first-page":"27","article-title":"The endoscopic endonasal approach for the management of craniopharyngiomas involving the third 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and hypothalamic injury: latest insights into consequent eating disorders and obesity","volume":"23","author":"M\u00fcller","year":"2016"},{"key":"b21-focus16317","series-title":"World Neurosurg","first-page":"266","article-title":"Endoscopic endonasal surgery for purely intrathird ventricle craniopharyngioma","volume":"91","author":"Nishioka","year":"2016"},{"key":"b22-focus16317","series-title":"J Clin Endocrinol Metab","first-page":"2211","article-title":"Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls","volume":"95","author":"O'Gorman","year":"2010"},{"key":"b23-focus16317","series-title":"J Neurooncol","first-page":"9","article-title":"A systematic review of cognitive performance in patients with childhood craniopharyngioma","volume":"125","author":"\u00d6zyurt","year":"2015"},{"key":"b24-focus16317","series-title":"J Neurosurg","first-page":"381","article-title":"Displacement of mammillary bodies by 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study","volume":"41","author":"Cohen","year":"1991"},{"key":"b6-focus16317","series-title":"Clin Endocrinol (Oxf)","first-page":"750","article-title":"Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable","volume":"74","author":"Crowley","year":"2011"},{"key":"b7-focus16317","series-title":"J Clin Med","first-page":"389","article-title":"Neuroendocrine disorders in pediatric craniopharyngioma patients","volume":"4","author":"Daubenb\u00fcchel","year":"2015"},{"issue":"1 Suppl","key":"b8-focus16317","series-title":"Neurosurg Focus","first-page":"5","article-title":"Surgical management of craniopharyngioma with third ventricle involvement","volume":"34","author":"de Lara","year":"2013"},{"key":"b9-focus16317","series-title":"Neuropediatrics","first-page":"159","article-title":"Systemic effects of hypothermia due to hypothalamic dysfunction after resection of a craniopharyngioma: case report and review of literature","volume":"44","author":"de Vetten","year":"2013"},{"key":"b10-focus16317","series-title":"J Clin Endocrinol Metab","first-page":"2376","article-title":"Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity","volume":"98","author":"Elowe-Gruau","year":"2013"},{"key":"b11-focus16317","series-title":"J Clin Endocrinol Metab","first-page":"3253","article-title":"Hypothalamic involvement predicts cognitive performance and psychosocial health in long-term survivors of childhood craniopharyngioma","volume":"98","author":"Fjalldal","year":"2013"},{"issue":"1 Suppl 1","key":"b12-focus16317","series-title":"Neurosurgery","first-page":"ONS75","article-title":"The endoscopic extended transsphenoidal approach for craniopharyngiomas","volume":"59","author":"Frank","year":"2006"},{"key":"b13-focus16317","series-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","year":"2007"},{"key":"b14-focus16317","series-title":"Eur J Endocrinol","first-page":"217","article-title":"Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review","volume":"171","author":"Joustra","year":"2014"},{"key":"b15-focus16317","series-title":"J Neurosurg","first-page":"715","article-title":"Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum","volume":"108","author":"Kassam","year":"2008"},{"key":"b16-focus16317","series-title":"J Neurooncol","first-page":"543","article-title":"Sleep dysfunction in long term survivors of craniopharyngioma","volume":"108","author":"Manley","year":"2012"},{"key":"b17-focus16317","series-title":"Ann Clin Transl Neurol","first-page":"130","article-title":"Mutant BRAF in low-grade epilepsy-associated tumors and focal cortical 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