{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:26:08Z","timestamp":1783473968961,"version":"3.55.0"},"reference-count":122,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Spine stereotactic radiosurgery (SSRS) has recently emerged as an increasingly effective treatment for spinal metastases. Studies performed over the past decade have examined the role of imaging in the diagnosis of metastases, as well as treatment response following SSRS. In this paper, the authors describe and review the utility of several imaging modalities in the diagnosis of spinal metastases and monitoring of their response to SSRS. Specifically, we review the role of CT, MRI, and positron emission tomography (PET) in their ability to differentiate between osteoblastic and osteolytic lesions, delineation of initial bony pathology, detection of treatment-related changes in bone density and vertebral compression fracture after SSRS, and tumor response to therapy. Validated consensus guidelines defining the imaging approach to SSRS are needed to standardize the diagnosis and treatment response assessment after SSRS. Future directions of spinal imaging, including advances in targeted tumor-specific molecular imaging markers demonstrate early promise for advancing the role of imaging in SSRS.<\/jats:p>","DOI":"10.3171\/2016.9.focus16350","type":"journal-article","created":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T03:37:18Z","timestamp":1483241838000},"page":"E5","source":"Crossref","is-referenced-by-count":24,"title":["Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery"],"prefix":"10.3171","volume":"42","author":[{"given":"Moaaz","family":"Soliman","sequence":"first","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil K.","family":"Taunk","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Simons","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Szerlip","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Michigan Cancer Center, Ann Arbor, Michigan; and\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Spratt","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-focus16350","series-title":"J Magn Reson Imaging","first-page":"257","article-title":"Oncologic applications of diffusion-weighted MRI in the body","volume":"35","author":"Bonekamp","year":"2012"},{"key":"b2-focus16350","series-title":"Breast","first-page":"98","article-title":"Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? 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