{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:03:19Z","timestamp":1766268199825,"version":"3.40.2"},"reference-count":56,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Advanced age is known to be associated with a poor prognosis after surgical clipping of unruptured intracranial aneurysms (UIAs). Keyhole clipping techniques have been introduced for less invasive treatment of UIAs. In this study, the authors compared the complications and clinical and radiological outcomes after keyhole clipping between nonfrail elderly patients (\u2265 70 years) and nonelderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Keyhole clipping (either supraorbital or pterional) was performed to treat 260 cases of relatively small (\u2264 10 mm) anterior circulation UIAs. There were 62 cases in the nonfrail elderly group (mean age 72.9 \u00b1 2.6 years [\u00b1 SD]) and 198 cases in the nonelderly group (mean age 59.5 \u00b1 7.6 years). The authors evaluated mortality and morbidity (modified Rankin Scale score &gt; 2 or Mini\u2013Mental State Examination [MMSE] score &lt; 24) at 3 months and 1 year after the operation, the general cognitive function by MMSE at 3 months and 1 year, anxiety and depression by the Beck Depression Inventory (BDI) and Hamilton Rating Scale for Depression (HAM-D) at 3 months, and radiological abnormalities and recurrence at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Basic characteristics including comorbidities, frailty, and BDI and HAM-D scores were not significantly different between the 2 groups, whereas the MMSE score was slightly but significantly lower in the elderly group. Aneurysm location, largest diameter, type of keyhole surgery, neck clipping rate, and hospitalization period were not significantly different between the 2 groups. The incidence of chronic subdural hematoma was not significantly higher in the elderly group than in the nonelderly group (8.1% vs 4.5%, p = 0.332); rates of other complications including stroke and epilepsy were not significantly different. Lacunar infarction occurred in 3.2% of the elderly group and 3.0% of the nonelderly group. No patient in the elderly group required re-treatment or demonstrated recurrence of clipped aneurysms. The MMSE score at 3 months significantly improved in the nonelderly group but did not change in the elderly group. The BDI and HAM-D scores at 3 months were significantly improved in both groups. No patient died in either group. The morbidity at 3 months and 1 year in the elderly group (1.6% and 4.8%, respectively) was not significantly different from that in the nonelderly group (2.0% and 1.5%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Keyhole clipping for nonfrail elderly patients with relatively small anterior circulation UIAs did not significantly increase the complication, mortality, or morbidity rate; hospitalization period; or aneurysm recurrence compared with nonelderly patients, and it was associated with improvement in anxiety and depression. Keyhole clipping to treat UIAs in the nonfrail elderly is an effective and long-lasting treatment.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.9.jns161634","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T15:01:14Z","timestamp":1483714874000},"page":"1307-1314","source":"Crossref","is-referenced-by-count":14,"title":["Validation of effectiveness of keyhole clipping in nonfrail elderly patients with unruptured intracranial aneurysms"],"prefix":"10.3171","volume":"127","author":[{"given":"Kentaro","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arata","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terushige","family":"Toyooka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tomura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Shizuoka Hospital, Izunokuni, Shizuoka; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Shizuoka Hospital, Izunokuni, Shizuoka; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns161634","series-title":"Curr Opin Anaesthesiol","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/ACO.0000000000000065","article-title":"The implication of frailty on preoperative risk assessment","volume":"27","author":"Amrock LG,","year":"2014","unstructured":"Amrock LG, Deiner S: The implication of frailty on preoperative risk assessment. 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