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A number of pathophysiological descriptions involving aberrant angiogenic responses following trauma, hemorrhage, or inflammation have been proposed, although the exact etiology of these lesions remains to be elucidated. Here, the authors present 2 cases of de novo AVM formation in adult patients. The first case involves the development of an AVM following a venous sinus thrombosis and to the authors' knowledge is the first of its kind to be reported in the literature. They also present a case in which an elderly patient with a previously ruptured AVM developed a second AVM in the contralateral hemisphere 11 years later. In addition to presenting these cases, the authors propose a possible mechanism for de novo AVM development in adult patients following ischemic injury.<\/jats:p>","DOI":"10.3171\/2016.9.jns161710","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T15:00:31Z","timestamp":1486738831000},"page":"506-510","source":"Crossref","is-referenced-by-count":15,"title":["De novo AVM formation following venous sinus thrombosis and prior AVM resection in adults: report of 2 cases"],"prefix":"10.3171","volume":"128","author":[{"given":"Siyu","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghav","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph J.","family":"Griessenauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimer","family":"Adeeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rouzbeh","family":"Motiei-Langroudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajith J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Ogilvy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"b1-jns161710","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E9","DOI":"10.3171\/2009.8.FOCUS09161","article-title":"The putative role of the venous system in the genesis of vascular malformations","volume":"27","author":"Aboian MS,","year":"2009","unstructured":"Aboian MS, Daniels DJ, Rammos SK, Pozzati E, Lanzino G: The putative role of the venous system in the genesis of vascular malformations. 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