{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:44:29Z","timestamp":1790441069515,"version":"4.1.0"},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Skull base chordoma is relatively rare, and a limited number of reports have been published regarding its clinical features. Moreover, the factors associated with extent of resection, as well as the value of marginal resection for long-term survival, are still in question for this disease. The objective of this study was to investigate these factors by evaluating their clinical features and surgical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective analysis of 238 patients with skull base chordomas, who met the inclusion criteria, was performed. This study summarized the clinical features, selection of approaches, degree of resection, and postoperative complications by statistical description analyses; proposed modified classifications of tumor location and bone invasion; studied the contributions of the clinical and radiological factors to the extent of resection by Pearson \u03c7<jats:sup>2<\/jats:sup>, ANOVA, rank test, and binary logistic regression analysis; and estimated the differences in overall survival and progression-free survival rates with respect to therapeutic history, classification of tumor location, extent of bone invasion, and extent of tumor resection by the Kaplan-Meier method. A p value &lt; 0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study included 140 male and 98 female patients with a mean age of 38.1 years. Headache and neck pain (33.2%) and diplopia (29%) were the most common initial symptoms. Sphenoclival type accounted for the largest proportion of tumor location (59.2%); endophytic chordoma was the more common type of bone invasion (81.5%). Lateral open approaches were performed in two-thirds of the study population (78.6%). The rate of marginal resection was 66%, composed of gross-total resection (11.8%) and near-total resection (54.2%). Meningitis (8%) and CSF leakage (3.8%) were the most frequent complications. The mean follow-up period was 43.7 months. The overall survival and progression-free survival rates at 5 years were 76% and 45%, respectively. Recurrent tumor and larger tumor volume (\u2265 40 cm<jats:sup>3<\/jats:sup>) were identified as risk factors of marginal resection. Patients who presented with recurrent tumor and underwent intralesional resection had a worse long-term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The classifications of both tumor location and bone invasion demonstrated clinical value. Marginal resection was more likely to be achieved for primary lesions with smaller volumes (&lt; 40 cm<jats:sup>3<\/jats:sup>). The rate of CSF leakage declined due to improved dura mater repair with free fat grafts. Marginal resection, or gross-total resection when possible, should be performed in patients with primary chordomas to achieve better long-term survival.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.9.jns16559","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T15:01:14Z","timestamp":1483714874000},"page":"1257-1267","source":"Crossref","is-referenced-by-count":67,"title":["Clinical features and surgical outcomes of patients with skull base chordoma: a retrospective analysis of 238 patients"],"prefix":"10.3171","volume":"127","author":[{"given":"Liang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaibing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns16559","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.clineuro.2014.12.015","article-title":"Disease outcomes for skull base and spinal chordomas: a single center experience","volume":"130","author":"Ahmed R,","year":"2015","unstructured":"Ahmed R, Sheybani A, Menezes AH, Buatti JM, Hitchon PW: Disease outcomes for skull base and spinal chordomas: a single center experience. Clin Neurol Neurosurg 130:67\u201373, 20152559066210.1016\/j.clineuro.2014.12.015"},{"key":"b2-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3171\/jns.1997.86.2.0182","article-title":"Skull base chordomas: a management challenge","volume":"86","author":"al-Mefty O,","year":"1997","unstructured":"al-Mefty O, Borba LA: Skull base chordomas: a management challenge. J Neurosurg 86:182\u2013189, 1997901041610.3171\/jns.1997.86.2.0182"},{"key":"b3-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1227\/NEU.0b013e3181fd2ac5","article-title":"The next step: innovative molecular targeted therapies for treatment of intracranial chordoma patients","volume":"68","author":"Barry JJ,","year":"2011","unstructured":"Barry JJ, Jian BJ, Sughrue ME, Kane AJ, Mills SA, Tihan T, : The next step: innovative molecular targeted therapies for treatment of intracranial chordoma patients. Neurosurgery 68:231\u2013241, 20112109971910.1227\/NEU.0b013e3181fd2ac5"},{"key":"b4-jns16559","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.wneu.2014.07.005","article-title":"Skull base chordoma and chondrosarcoma: influence of clinical and demographic factors on prognosis: a SEER analysis","volume":"82","author":"Bohman LE,","year":"2014","unstructured":"Bohman LE, Koch M, Bailey RL, Alonso-Basanta M, Lee JY: Skull base chordoma and chondrosarcoma: influence of clinical and demographic factors on prognosis: a SEER analysis. World Neurosurg 82:806\u2013814, 20142500916510.1016\/j.wneu.2014.07.005"},{"key":"b5-jns16559","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/01.brs.0000200038.30869.27","article-title":"Chordoma of the mobile spine: fifty years of experience","volume":"31","author":"Boriani S,","year":"2006","unstructured":"Boriani S, Bandiera S, Biagini R, Bacchini P, Boriani L, Cappuccio M, : Chordoma of the mobile spine: fifty years of experience. Spine (Phila Pa 1976) 31:493\u2013503, 200610.1097\/01.brs.0000200038.30869.27"},{"key":"b6-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1227\/01.NEU.0000362000.35742.3D","article-title":"Outcome of 132 operations in 97 patients with chordomas of the craniocervical junction and upper cervical spine","volume":"66","author":"Choi D,","year":"2010","unstructured":"Choi D, Melcher R, Harms J, Crockard A: Outcome of 132 operations in 97 patients with chordomas of the craniocervical junction and upper cervical spine. Neurosurgery 66:59\u201365, 20102002353810.1227\/01.NEU.0000362000.35742.3D"},{"key":"b7-jns16559","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.jocn.2015.05.024","article-title":"Predictors of recurrence following resection of intracranial chordomas","volume":"22","author":"Choy W,","year":"2015","unstructured":"Choy W, Terterov S, Kaprealian TB, Trang A, Ung N, DeSalles A, : Predictors of recurrence following resection of intracranial chordomas. J Clin Neurosci 22:1792\u20131796, 20152620991910.1016\/j.jocn.2015.05.024"},{"key":"b8-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"E387","DOI":"10.1227\/01.NEU.0000337064.57270.F0","article-title":"Intradural clival chordoma and ecchordosis physaliphora: a challenging differential diagnosis: case report","volume":"64","author":"Ciarpaglini R,","year":"2009","unstructured":"Ciarpaglini R, Pasquini E, Mazzatenta D, Ambrosini-Spaltro A, Sciarretta V, Frank G: Intradural clival chordoma and ecchordosis physaliphora: a challenging differential diagnosis: case report. Neurosurgery 64:E387\u2013E388, 20091919044410.1227\/01.NEU.0000337064.57270.F0"},{"key":"b9-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3171\/jns.2001.95.6.0933","article-title":"Chordomas of the craniocervical junction: follow-up review and prognostic factors","volume":"95","author":"Colli B,","year":"2001","unstructured":"Colli B, Al-Mefty O: Chordomas of the craniocervical junction: follow-up review and prognostic factors. J Neurosurg 95:933\u2013943, 20011176583710.3171\/jns.2001.95.6.0933"},{"key":"b10-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3171\/jns.2001.95.2.0175","article-title":"A multidisciplinary team approach to skull base chordomas","volume":"95","author":"Crockard HA,","year":"2001","unstructured":"Crockard HA, Steel T, Plowman N, Singh A, Crossman J, Revesz T, : A multidisciplinary team approach to skull base chordomas. J Neurosurg 95:175\u2013183, 20011178088510.3171\/jns.2001.95.2.0175"},{"key":"b11-jns16559","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1097\/PAS.0b013e31805c9967","article-title":"Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma","volume":"31","author":"Deshpande V,","year":"2007","unstructured":"Deshpande V, Nielsen GP, Rosenthal DI, Rosenberg AE: Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma. Am J Surg Pathol 31:1573\u20131577, 20071789576010.1097\/PAS.0b013e31805c9967"},{"key":"b12-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1227\/NEU.0b013e3182446783","article-title":"Current surgical outcomes for cranial base chordomas: cohort study of 95 patients","volume":"70","author":"Di Maio S,","year":"2012","unstructured":"Di Maio S, Rostomily R, Sekhar LN: Current surgical outcomes for cranial base chordomas: cohort study of 95 patients. Neurosurgery 70:1355\u20131360, 20122215754510.1227\/NEU.0b013e3182446783"},{"key":"b13-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3171\/2011.7.JNS11355","article-title":"Current comprehensive management of cranial base chordomas: 10-year meta-analysis of observational studies","volume":"115","author":"Di Maio S,","year":"2011","unstructured":"Di Maio S, Temkin N, Ramanathan D, Sekhar LN: Current comprehensive management of cranial base chordomas: 10-year meta-analysis of observational studies. J Neurosurg 115:1094\u20131105, 20112181919710.3171\/2011.7.JNS11355"},{"key":"b14-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3171\/jns.1993.78.5.0741","article-title":"Intracranial chordomas: a clinicopathological and prognostic study of 51 cases","volume":"78","author":"Forsyth PA,","year":"1993","unstructured":"Forsyth PA, Cascino TL, Shaw EG, Scheithauer BW, O'Fallon JR, Dozier JC, : Intracranial chordomas: a clinicopathological and prognostic study of 51 cases. J Neurosurg 78:741\u2013747, 1993846860510.3171\/jns.1993.78.5.0741"},{"key":"b15-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.3171\/2009.7.JNS081504","article-title":"Endoscopic endonasal transclival resection of chordomas: operative technique, clinical outcome, and review of the literature","volume":"112","author":"Fraser JF,","year":"2010","unstructured":"Fraser JF, Nyquist GG, Moore N, Anand VK, Schwartz TH: Endoscopic endonasal transclival resection of chordomas: operative technique, clinical outcome, and review of the literature. J Neurosurg 112:1061\u20131069, 20101969804310.3171\/2009.7.JNS081504"},{"key":"b16-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1227\/NEU.0000000000000611","article-title":"Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities","volume":"76","author":"Jahangiri A,","year":"2015","unstructured":"Jahangiri A, Chin AT, Wagner JR, Kunwar S, Ames C, Chou D, : Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. Neurosurgery 76:179\u2013186, 20152559419110.1227\/NEU.0000000000000611"},{"key":"b17-jns16559","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3109\/02688697.2010.546896","article-title":"A comprehensive analysis of intracranial chordoma and survival: a systematic review","volume":"25","author":"Jian BJ,","year":"2011","unstructured":"Jian BJ, Bloch OG, Yang I, Han SJ, Aranda D, Parsa AT: A comprehensive analysis of intracranial chordoma and survival: a systematic review. Br J Neurosurg 25:446\u2013453, 20112174918410.3109\/02688697.2010.546896"},{"key":"b18-jns16559","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.jocn.2014.02.008","article-title":"Outcomes and patterns of care in adult skull base chordomas from the Surveillance, Epidemiology, and End Results (SEER) database","volume":"21","author":"Jones PS,","year":"2014","unstructured":"Jones PS, Aghi MK, Muzikansky A, Shih HA, Barker FG II, Curry WT Jr: Outcomes and patterns of care in adult skull base chordomas from the Surveillance, Epidemiology, and End Results (SEER) database. J Clin Neurosci 21:1490\u20131496, 20142485290310.1016\/j.jocn.2014.02.008"},{"key":"b19-jns16559","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.wneu.2011.02.026","article-title":"The endoscope-assisted ventral approach compared with open microscope-assisted surgery for clival chordomas","volume":"76","author":"Komotar RJ,","year":"2011","unstructured":"Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH: The endoscope-assisted ventral approach compared with open microscope-assisted surgery for clival chordomas. World Neurosurg 76:318\u2013327, 20112198643110.1016\/j.wneu.2011.02.026"},{"key":"b20-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1227\/NEU.0b013e31825ea3e0","article-title":"Endoscopic endonasal approach for resection of cranial base chordomas: outcomes and learning curve","volume":"71","author":"Koutourousiou M,","year":"2012","unstructured":"Koutourousiou M, Gardner PA, Tormenti MJ, Henry SL, Stef ko ST, Kassam AB, : Endoscopic endonasal approach for resection of cranial base chordomas: outcomes and learning curve. Neurosurgery 71:614\u2013625, 20122259232810.1227\/NEU.0b013e31825ea3e0"},{"key":"b21-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"812","DOI":"10.3171\/jns.2003.98.4.0812","article-title":"Chordoma of the skull base: predictors of tumor recurrence","volume":"98","author":"Pallini R,","year":"2003","unstructured":"Pallini R, Maira G, Pierconti F, Falchetti ML, Alvino E, Cimino-Reale G, : Chordoma of the skull base: predictors of tumor recurrence. J Neurosurg 98:812\u2013822, 20031269140710.3171\/jns.2003.98.4.0812"},{"key":"b22-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3171\/2013.11.JNS131137","article-title":"Male sex as a risk factor for the clinical course of skull base chordomas","volume":"120","author":"Rachinger W,","year":"2014","unstructured":"Rachinger W, Eigenbrod S, D\u00fctzmann S, Simon M, Feigl GC, Kremenevskaja N, : Male sex as a risk factor for the clinical course of skull base chordomas. J Neurosurg 120:1313\u20131320, 20142440507510.3171\/2013.11.JNS131137"},{"key":"b23-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3171\/JNS-07\/08\/0319","article-title":"Chordomas of the skull base: surgical management and outcome","volume":"107","author":"Samii A,","year":"2007","unstructured":"Samii A, Gerganov VM, Herold C, Hayashi N, Naka T, Mirzayan MJ, : Chordomas of the skull base: surgical management and outcome. J Neurosurg 107:319\u2013324, 20071769538610.3171\/JNS-07\/08\/0319"},{"key":"b24-jns16559","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3171\/2009.9.JNS08596","article-title":"Clival chordomas: clinical management, results, and complications in 71 patients","volume":"113","author":"Sen C,","year":"2010","unstructured":"Sen C, Triana AI, Berglind N, Godbold J, Shrivastava RK: Clival chordomas: clinical management, results, and complications in 71 patients. J Neurosurg 113:1059\u20131071, 20101992919810.3171\/2009.9.JNS08596"},{"key":"b25-jns16559","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1200\/JCO.2011.35.3656","article-title":"Phase II study of imatinib in advanced chordoma","volume":"30","author":"Stacchiotti S,","year":"2012","unstructured":"Stacchiotti S, Longhi A, Ferraresi V, Grignani G, Comandone A, Stupp R, : Phase II study of imatinib in advanced chordoma. J Clin Oncol 30:914\u2013920, 20122233194510.1200\/JCO.2011.35.3656"},{"key":"b26-jns16559","series-title":"Ann Oncol","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1093\/annonc\/mdp210","article-title":"Response to imatinib plus sirolimus in advanced chordoma","volume":"20","author":"Stacchiotti S,","year":"2009","unstructured":"Stacchiotti S, Marrari A, Tamborini E, Palassini E, Virdis E, Messina A, : Response to imatinib plus sirolimus in advanced chordoma. Ann Oncol 20:1886\u20131894, 20091957096110.1093\/annonc\/mdp210"},{"key":"b27-jns16559","series-title":"Lancet Oncol","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1016\/S1470-2045(14)71190-8","article-title":"Building a global consensus approach to chordoma: a position paper from the medical and patient community","volume":"16","author":"Stacchiotti S,","year":"2015","unstructured":"Stacchiotti S, Sommer J: Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol 16:e71\u2013e83, 20152563868310.1016\/S1470-2045(14)71190-8"},{"key":"b28-jns16559","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1227\/01.NEU.0000223441.51012.9D","article-title":"Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chordomas","volume":"59","author":"Tzortzidis F,","year":"2006","unstructured":"Tzortzidis F, Elahi F, Wright D, Natarajan SK, Sekhar LN: Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chordomas. Neurosurgery 59:230\u2013237, 20061688316310.1227\/01.NEU.0000223441.51012.9D"},{"key":"b29-jns16559","series-title":"Lancet Oncol","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1016\/S1470-2045(11)70337-0","article-title":"Chordoma: current concepts, management, and future directions","volume":"13","author":"Walcott BP,","year":"2012","unstructured":"Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ: Chordoma: current concepts, management, and future directions. Lancet Oncol 13:e69\u2013e76, 20122230086110.1016\/S1470-2045(11)70337-0"},{"key":"b30-jns16559","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.clineuro.2014.12.016","article-title":"Surgical resection of upper-middle clivus chordomas via a modified anterior transpetrous approach","volume":"130","author":"Wang K,","year":"2015","unstructured":"Wang K, Wang L, Tian K, Xiao X, Wu Z, Jia G, : Surgical resection of upper-middle clivus chordomas via a modified anterior transpetrous approach. Clin Neurol Neurosurg 130:20\u201325, 201510.1016\/j.clineuro.2014.12.016"},{"key":"b31-jns16559","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.wneu.2012.12.037","article-title":"Clinical and pathological features of intradural retroclival chordoma","volume":"82","author":"Wang L,","year":"2014","unstructured":"Wang L, Wu Z, Tian K, Li G, Zhang J: Clinical and pathological features of intradural retroclival chordoma. World Neurosurg 82:791\u2013798, 20142341663210.1016\/j.wneu.2012.12.037"},{"key":"b32-jns16559","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0119523","DOI":"10.1371\/journal.pone.0119523","article-title":"Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis","volume":"10","author":"Wu Z,","year":"2015","unstructured":"Wu Z, Wang L, Guo Z, Wang K, Zhang Y, Tian K, : Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis. PLoS One 10:e0119523, 201510.1371\/journal.pone.0119523"},{"key":"b33-jns16559","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s10143-010-0273-6","article-title":"Prognostic factors for long-term outcome of patients with surgical resection of skull base chordomas\u2014106 cases review in one institution","volume":"33","author":"Wu Z,","year":"2010","unstructured":"Wu Z, Zhang J, Zhang L, Jia G, Tang J, Wang L, : Prognostic factors for long-term outcome of patients with surgical resection of skull base chordomas\u2014106 cases review in one institution. Neurosurg Rev 33:451\u2013456, 20102066890410.1007\/s10143-010-0273-6"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/6\/article-p1257.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/6\/article-p1257.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/127\/6\/article-p1257.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T02:19:24Z","timestamp":1742696364000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/127\/6\/article-p1257.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":33,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2016.9.jns16559","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}