{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:12Z","timestamp":1789500612442,"version":"build-2803163510"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The goal of this study was to compare the recovery of neuronal metabolism and functional reorganization in the primary motor cortex (M1) between mild and moderate cervical spondylotic myelopathy (CSM) following surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty-eight patients with CSM underwent 3-T MRI scans that included spectroscopy and functional MRI, before surgery and 6 months postsurgery. The classification of severity was based on the modified Japanese Orthopaedic Association questionnaire. Mild and moderate myelopathy were defined by modified Japanese Orthopaedic Association scores &gt; 12 of 18 (n = 15) and 9\u201312 (n = 13), respectively. Ten healthy control subjects underwent 2 MRI scans 6 months apart. Metabolite levels were measured in the M1 contralateral to the greater deficit side in patients with CSM and on both sides in the controls. Motor function was assessed using a right finger\u2013tapping paradigm and analyzed with BrainVoyager QX.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients with mild CSM had a lower preoperative <jats:italic>N<\/jats:italic>-acetylaspartate to creatine (NAA\/Cr) ratio compared with moderate CSM, suggesting mitochondrial dysfunction. Postsurgery, NAA\/Cr in moderate CSM decreased to the levels observed in mild CSM. Preoperatively, patients with mild CSM had a larger volume of activation (VOA) in the M1 than those with moderate CSM. Postoperatively, the VOAs were comparable between the mild and moderate CSM groups and had shifted toward the primary sensory cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The NAA\/Cr ratio and VOA size in the M1 can be used to discriminate between mild and moderate CSM. Postsurgery, the metabolite profile of the M1 did not recover in either group, despite significant clinical improvement. The authors proposed that metabolic impairment in the M1 may trigger the recruitment of adjacent healthy cortex to achieve functional recovery.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2016.9.spine151507","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T15:02:31Z","timestamp":1486134151000},"page":"547-553","source":"Crossref","is-referenced-by-count":29,"title":["Metabolite and functional profile of patients with cervical spondylotic myelopathy"],"prefix":"10.3171","volume":"26","author":[{"given":"Izabela","family":"Aleksanderek","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics and"},{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd K.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics and"},{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bartha","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics and"},{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Duggal","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics and"},{"name":"Department of Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Magn Reson Med","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/1522-2594(200010)44:4<641::AID-MRM19>3.0.CO;2-G","article-title":"Spectroscopic lineshape correction by QUECC: combined QUALITY deconvolution and eddy current correction","volume":"44","author":"Bartha R,","year":"2000","unstructured":"Bartha R, Drost DJ, Menon RS, Williamson PC: Spectroscopic lineshape correction by QUECC: combined QUALITY deconvolution and eddy current correction. 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