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The purpose of this study was to evaluate these medullary streaks both clinically and radiologically and to discuss associated pathophysiological concerns.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors retrospectively reviewed data from 14 consecutive pediatric patients with moyamoya disease treated between April 2009 and June 2016. Clinical and radiological features and postoperative imaging changes were analyzed. In 4 patients, hyperintense medullary streaks on FLAIR imaging (HMSF) at the level of the centrum semiovale were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The HMSF were coincident with hyperintense medullary streaks on a T2-weighted image, though they were not completely coincident with the vasculature on either a T2*-weighted image or contrast-enhanced CT. Analysis revealed significantly higher values in terms of MR angiography scores, number of flow voids of the basal ganglia, and the presence of the medullary artery in the group with HMSF than in those without. In contrast, the presence of white matter damage was significantly less frequent in the HMSF group. All HMSF disappeared after surgery, and the mean apparent diffusion coefficient at the same level was significantly reduced postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Although HMSF should be associated with collateral circulation in moyamoya disease, other factors may be involved, including stagnated cerebrospinal fluid or vasogenic edema that is relevant to the impaired state of the white matter. Findings in this study provide insight into the pathophysiological basis of the perivascular space in moyamoya disease.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.1.peds16541","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T14:58:48Z","timestamp":1489157928000},"page":"560-566","source":"Crossref","is-referenced-by-count":15,"title":["Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease"],"prefix":"10.3171","volume":"19","author":[{"given":"Hime","family":"Suzuki","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Mikami","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyoshi","family":"Kuribara","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Yoshifuji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hokkaido Medical Center for Child Health and Rehabilitation; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Public Health, Sapporo Medical University;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohiro","family":"Houkin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Mikuni","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds16541","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0022-510X(85)90139-X","article-title":"Inflammatory vasculitis in multiple sclerosis","volume":"69","author":"Adams CW","year":"1985","unstructured":"Adams CW, Poston RN, Buk SJ, Sidhu YS, Vipond H: Inflammatory vasculitis in multiple sclerosis. 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