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In this study, the Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive changes in aSAH patients treated with the Maryland LDIVH protocol compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective analysis of all patients treated for aSAH between July 2009 and April 2014 was conducted. Beginning in 2012, aSAH patients were treated with LDIVH in the postprocedural period. The MoCA was administered to all aSAH survivors prospectively during routine follow-up visits, at least 3 months after aSAH, by trained staff blinded to treatment status. Mean MoCA scores were compared between groups, and regression analyses were performed for relevant factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>No significant differences in baseline characteristics were observed between groups. The mean MoCA score for the LDIVH group (n = 25) was 26.4 compared with 22.7 in controls (n = 22) (p = 0.013). Serious cognitive impairment (MoCA \u2264 20) was observed in 32% of controls compared with 0% in the LDIVH group (p = 0.008). Linear regression analysis demonstrated that only LDIVH was associated with a positive influence on MoCA scores (\u03b2 = 3.68, p =0.019), whereas anterior communicating artery aneurysms and fevers were negatively associated with MoCA scores. Multivariable linear regression analysis resulted in all 3 factors maintaining significance. There were no treatment complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This preliminary study suggests that the Maryland LDIVH protocol may improve cognitive outcomes in aSAH patients. A randomized controlled trial is needed to determine the safety and potential benefit of unfractionated heparin in aSAH patients.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.11.jns17894","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T13:59:16Z","timestamp":1526047156000},"page":"1460-1467","source":"Crossref","is-referenced-by-count":21,"title":["Continuous infusion of low-dose unfractionated heparin after aneurysmal subarachnoid hemorrhage: a preliminary study of cognitive outcomes"],"prefix":"10.3171","volume":"130","author":[{"given":"Robert F.","family":"James","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky;"},{"name":"Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas K.","family":"Khattar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid S.","family":"Aljuboori","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Y.","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacey M.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly S.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, University of Louisville School of Public Health, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Craycroft","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, University of Louisville School of Public Health, Louisville, Kentucky;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Gaughen","sequence":"additional","affiliation":[{"name":"Sentara Martha Jefferson Hospital, Charlottesville, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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