{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:33:09Z","timestamp":1778131989713,"version":"3.51.4"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Repetitive subconcussive head trauma is a consequence of participation in contact sports and may be linked to neurodegenerative diseases. The degree of neurological injury caused by subconcussive head trauma is not easily detectible, and this injury does not induce readily identifiable clinical signs or symptoms. Recent advancements in immunoassays make possible the detection and quantification of blood biomarkers linked to head trauma. Identification of a blood biomarker that can identify the extent of neurological injury associated with subconcussive head trauma may provide an objective measure for informed decisions concerning cumulative exposure to subconcussive head trauma. The purpose of the current study was to examine changes in the blood biomarkers of subconcussive head trauma over the course of an American football season.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Thirty-five National Collegiate Athletic Association (NCAA) American football athletes underwent blood sampling throughout the course of a football season. Serial samples were obtained throughout the 2016 season, during which the number and magnitude of head impacts changed. Blood samples were analyzed for plasma concentrations of tau and serum concentrations of neurofilament light polypeptide (NF-L). Athletes were grouped based on their starter status, because athletes identified as starters are known to sustain a greater number of impacts. Between-group differences and time-course differences were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In nonstarters, plasma concentrations of tau decreased over the course of the season, with lower values observed in starters; this resulted in a lower area under the curve (AUC) (starters: 416.78 \u00b1 129.17 pg\/ml\/day; nonstarters: 520.84 \u00b1 163.19 pg\/ml\/day; p = 0.050). Plasma concentrations of tau could not be used to discern between starters and nonstarters. In contrast, serum concentrations of NF-L increased throughout the season as head impacts accumulated, specifically in those athletes categorized as starters. The higher serum concentrations of NF-L observed in starters resulted in a larger AUC (starters: 1605.03 \u00b1 655.09 pg\/ml\/day; nonstarters: 1067.29 \u00b1 272.33 pg\/ml\/day; p = 0.007). The AUC of the receiver operating characteristic curve analyses displayed fair to modest accuracy to identify athletes who were starters with the use of serum NF-L following periods of repetitive impacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The different patterns observed in serum NF-L and plasma tau concentrations provide preliminary evidence for the use of blood biomarkers to detect the neurological injury associated with repetitive subconcussive head trauma. Although further investigation is necessary, such findings might lay the foundation for the further development of an objective measure for the detection of neurological injury caused by subconcussive head trauma.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.12.jns172035","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T08:01:14Z","timestamp":1527580874000},"page":"1655-1662","source":"Crossref","is-referenced-by-count":28,"title":["Fluctuations in blood biomarkers of head trauma in NCAA football athletes over the course of a season"],"prefix":"10.3171","volume":"130","author":[{"given":"Jonathan M.","family":"Oliver","sequence":"first","affiliation":[{"name":"Sports Concussion Research Group, Department of Kinesiology, Texas Christian University;"},{"name":"Texas Health Sports Medicine Concussion Center; and"},{"name":"Texas Health Sports Medicine, Fort Worth, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Anzalone","sequence":"additional","affiliation":[{"name":"Sports Concussion Research Group, Department of Kinesiology, Texas Christian University;"},{"name":"Texas Health Sports Medicine Concussion Center; and"},{"name":"Texas Health Sports Medicine, Fort Worth, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Stone","sequence":"additional","affiliation":[{"name":"Sports Concussion Research Group, Department of Kinesiology, Texas Christian University;"},{"name":"Texas Health Sports Medicine Concussion Center; and"},{"name":"Texas Health Sports Medicine, Fort Worth, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Turner","sequence":"additional","affiliation":[{"name":"Sports Concussion Research Group, Department of Kinesiology, Texas Christian University;"},{"name":"Texas Health Sports Medicine Concussion Center; and"},{"name":"Texas Health Sports Medicine, Fort Worth, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damond","family":"Blueitt","sequence":"additional","affiliation":[{"name":"Sports Concussion Research Group, Department of Kinesiology, Texas Christian University;"},{"name":"Texas Health Sports Medicine Concussion Center; and"},{"name":"Texas Health Sports Medicine, Fort Worth, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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