{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:01:02Z","timestamp":1780736462938,"version":"3.54.1"},"reference-count":60,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Flow diversion has proven to be an efficacious means of treating cerebral aneurysms that are refractory to other therapeutic means. Patients with tandem aneurysms treated with flow diversion have been included in larger, previously reported series; however, there are no dedicated reports on using this technique during a single session to treat this unique subset of patients. Therefore, the authors analyzed the outcomes of patients who had undergone single-session flow diversion for the treatment of tandem aneurysms.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The authors conducted a retrospective review of flow diversion with the Pipeline embolization device (PED) for the treatment of tandem aneurysms in a single session at 2 participating medical centers: University of Utah, Salt Lake City, Utah, and Barrow Neurological Institute, Phoenix, Arizona. Patient demographic data, aneurysm characteristics, treatment strategy and results, complications, and follow-up data were collected from the medical record and analyzed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Between January 2011 and December 2015, 17 patients (12 female, 5 male) with a total of 38 aneurysms (mean size 4.7 \u00b1 2.7 mm, mean \u00b1 SD) were treated. Sixteen patients had aneurysms in the anterior circulation, and 1 patient had tandem aneurysms in the posterior circulation. Twelve patients underwent only placement of a PED, whereas 5 underwent adjunctive coil embolization of at least 1 aneurysm. One PED was used in each of 9 patients, and 2 PEDs were required in each of 8 patients. There were 2 intraprocedural complications; however, in both instances, the patients were asymptomatic at the last follow-up. The follow-up imaging studies were available for 15 patients at a mean of 7 months after treatment (216 days, range 0\u2013540 days). The mean initial Raymond score after treatment was 2.7 \u00b1 0.7, and the mean final score was 1.3 \u00b1 0.7.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n In this series, the use of flow diversion for the treatment of tandem cerebral aneurysms had an acceptable safety profile, indicating that it should be considered as an effective therapy for this complicated subset of patients. Further prospective studies must be performed before more definitive conclusions can be made.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2017.2.focus1731","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T03:36:47Z","timestamp":1496288207000},"page":"E10","source":"Crossref","is-referenced-by-count":12,"title":["Flow diversion of tandem cerebral aneurysms: a multi-institutional retrospective study"],"prefix":"10.3171","volume":"42","author":[{"given":"Al-Wala","family":"Awad","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam","family":"Moon","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus D.","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Yashar S.","family":"Kalani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Taussky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron G.","family":"McDougall","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe C.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","first-page":"165","article-title":"Treatment of ruptured intracranial aneurysms with the Pipeline Embolization Device","volume":"76","author":"Chalouhi N","year":"2015","unstructured":"Chalouhi N, Zanaty M, Whiting A, Tjoumakaris S, Hasan D, Ajiboye N, : Treatment of ruptured intracranial aneurysms with the Pipeline Embolization Device. 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Stroke 32:1998\u20132004, 2001"},{"key":"b23","series-title":"AJNR Am J Neuroradiol","first-page":"1436","article-title":"Treatment of intracranial aneurysms using the pipeline flow-diverter embolization device: a single-center experience with long-term follow-up results","volume":"33","author":"Saatci I","year":"2012","unstructured":"Saatci I, Yavuz K, Ozer C, Geyik S, Cekirge HS: Treatment of intracranial aneurysms using the pipeline flow-diverter embolization device: a single-center experience with long-term follow-up results. 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AJNR Am J Neuroradiol 31:1139\u20131147, 2010"},{"key":"b27","series-title":"Cochrane Database Syst Rev (4)","article-title":"Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage","author":"van der Schaaf I","year":"2005","unstructured":"van der Schaaf I, Algra A, Wermer M, Molyneux A, Clarke M, van Gijn J, : Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev (4):CD003085, 2005"},{"key":"b28","series-title":"Lancet Neurol","first-page":"626","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"Vlak MH","year":"2011","unstructured":"Vlak MH, Algra A, Brandenburg R, Rinkel GJ: Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 10:626\u2013636, 2011"},{"key":"b29","series-title":"J Neurointerv Surg","first-page":"27","article-title":"The safety and efficacy of coiling multiple aneurysms in the same session","volume":"4","author":"Xavier AR","year":"2012","unstructured":"Xavier AR, Rayes M, Pandey P, Tiwari A, Kansara A, Guthikonda M: The safety and efficacy of coiling multiple aneurysms in the same session. 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