{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:45:45Z","timestamp":1790721945982,"version":"4.1.0"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Recent studies have shed light on the molecular makeup of diffuse intrinsic pontine gliomas and led to the identification of potential treatment targets for these lesions, which account for the majority of pediatric brainstem tumors (pedBSTs). Therefore, stereotactic biopsy\u2013driven molecular characterization of pedBSTs may become an important prerequisite for the management of these fatal brain tumors. The authors conducted a systemic review and meta-analysis to precisely determine the safety and diagnostic success of stereotactic biopsy of pedBSTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A systematic search of PubMed, EMBASE, and the Web of Science yielded 944 potentially eligible abstracts. Meta-analysis was conducted on 18 studies (including the authors\u2019 own institutional series), describing a total of 735 biopsy procedures for pedBSTs. The primary outcome measures were diagnostic success and procedure-related complications. Pooled estimates were calculated based on the Freeman-Tukey double-arcsine transformation and DerSimonian-Laird random-effects model. Heterogeneity, sensitivity, and meta-regression analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The weighted average proportions across the analyzed studies were 96.1% (95% CI 93.5%\u201398.1%) for diagnostic success, 6.7% (95% CI 4.2%\u20139.6%) for overall morbidity, 0.6% (95% CI 0.2%\u20131.4%) for permanent morbidity, and 0.6% (95% CI 0.2%\u20131.3%) for mortality. Subgroup analyses at the study level identified no significant correlation between the outcome measures and the distribution of the chosen biopsy trajectories (transfrontal vs transcerebellar), age, year of publication, or the number of biopsy procedures annually performed in each center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Stereotactic biopsy of pedBSTs is safe and allows successful tissue sampling as a prerequisite for the molecular characterization and the identification of potentially druggable targets toward more individualized treatment concepts to improve the outcome for children harboring such lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2017.2.peds1665","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T09:58:27Z","timestamp":1497607107000},"page":"261-268","source":"Crossref","is-referenced-by-count":125,"title":["Update on the diagnostic value and safety of stereotactic biopsy for pediatric brainstem tumors: a systematic review and meta-analysis of 735 cases"],"prefix":"10.3171","volume":"20","author":[{"given":"Christina","family":"Hamisch","sequence":"first","affiliation":[{"name":"Departments of General Neurosurgery,"},{"name":"Center of Integrated Oncology (CIO), University of Cologne; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Kickingereder","sequence":"additional","affiliation":[{"name":"Stereotaxy and Functional Neurosurgery, and"},{"name":"Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Fischer","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology, University Hospital of Cologne;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Simon","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology, University Hospital of Cologne;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian I.","family":"Ruge","sequence":"additional","affiliation":[{"name":"Departments of General Neurosurgery,"},{"name":"Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3171\/jns.1989.70.2.0195","article-title":"Stereotaxic suboccipital transcerebellar biopsy of pontine mass lesions","volume":"70","author":"Abernathey CD","year":"1989","unstructured":"Abernathey CD, Camacho A, Kelly PJ: Stereotaxic suboccipital transcerebellar biopsy of pontine mass lesions. 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