{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:12Z","timestamp":1789785792397,"version":"4.0.1"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Gamma Knife radiosurgery (GKRS) has become an accepted treatment for vestibular schwannoma, with a high rate of tumor control and good clinical outcome. In a small number of cases, additional treatment is needed. This retrospective study examines the clinical outcome, reproducibility of volumetric response patterns, and tumor control rate after administering a second GKRS to treat vestibular schwannomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 38 patients were included: 28 patients underwent a radiosurgical procedure as the initial treatment (Group 1), and 10 patients underwent microsurgical resection with adjuvant radiosurgery on the tumor remnant as the initial treatment (Group 2). The indication for a second GKRS treatment was growth observed on follow-up imaging. The median margin dose was 11.0 Gy for the first procedure and 11.5 Gy for the second procedure. Tumor control after retreatment was assessed through volumetric analysis. Clinical outcome was assessed through medical chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Median tumor volume at retreatment was 3.6 cm<jats:sup>3<\/jats:sup>, with a median treatment interval of 49 months. All patients showed tumor control in a median follow-up period of 75 months after the second radiosurgical procedure. Volumetric tumor response after the second procedure did not correspond to response after the first procedure. After retreatment, persisting House-Brackmann Grade II facial nerve dysfunction was observed in 3 patients (7.9%), facial spasms in 5 patients (13%), and trigeminal nerve hypesthesia in 3 patients (7.9%). Hearing preservation was not evaluated because of the small number of patients with serviceable hearing at the second procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Repeat GKRS after a failed first treatment appears to be an effective strategy in terms of tumor control. The volumetric response after a repeat procedure could not be predicted by the volumetric response observed after first treatment. This justifies considering repeat GKRS even for tumors that do not show any volumetric response and show continuous growth after first treatment. An increased risk of mild facial and trigeminal nerve dysfunction was observed after the second treatment compared with the first treatment.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.3.jns162033","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T13:59:10Z","timestamp":1507298350000},"page":"137-145","source":"Crossref","is-referenced-by-count":39,"title":["Retreatment of vestibular schwannoma with Gamma Knife radiosurgery: clinical outcome, tumor control, and review of literature"],"prefix":"10.3171","volume":"129","author":[{"given":"Victor X.","family":"Fu","sequence":"first","affiliation":[{"name":"Gamma Knife Center Tilburg, Department of Neurosurgery, St. Elisabeth Hospital, Tilburg; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen B.","family":"Verheul","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Tilburg, Department of Neurosurgery, St. Elisabeth Hospital, Tilburg; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus N.","family":"Beute","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Tilburg, Department of Neurosurgery, St. Elisabeth Hospital, Tilburg; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieger","family":"Leenstra","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Tilburg, Department of Neurosurgery, St. Elisabeth Hospital, Tilburg; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henricus P. 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