{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:47:01Z","timestamp":1785217621807,"version":"3.55.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Although intracranial vessel remodeling has been observed in moyamoya disease, concerns remain regarding the effect of bypass surgery on hemodynamic changes within the internal carotid artery (ICA). The authors aimed to quantify the surgical effect of bypass surgery on bilateral ICAs in moyamoya disease and to estimate pressure drop (PD) along the length of the ICA to predict surgical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Records of patients who underwent bypass surgery for treatment of moyamoya disease and in whom flow rates were obtained pre- and postsurgery by quantitative MR angiography were retrospectively reviewed. Quantitative MR angiography and computational fluid dynamics were applied to measure morphological and hemodynamic changes during pre- and postbypass procedures. The results for vessel diameter, volumetric flow, PD, and mean wall shear stress along the length of the ICA were analyzed. Subgroup analysis was performed for the circle of Willis (CoW) configurations.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty-three patients were included. The PD in ICAs on the surgical side (surgical ICAs) decreased by 21.18% (SD \u00b1 30.1%) and increased by 11.75% (SD \u00b1 28.6%) in ICAs on the nonsurgical side (contralateral ICAs) (p = 0.001). When the PD in contralateral ICAs was compared between patients with a complete or incomplete CoW, the authors found that the PDI in the former group decreased by 2.45% and increased by 20.88% in the latter (p = 0.05). Regression tests revealed that a greater postoperative decrease in PD corresponded to shrinking of ICAs (R<jats:sup>2<\/jats:sup> = 0.22, p = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>PD may be used as a reliable biomechanical indicator for the assessment of surgical treatment outcomes. The vessel remodeling characteristics of contralateral ICA were related to CoW configurations.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.5.jns163112","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T13:59:51Z","timestamp":1508507991000},"page":"677-683","source":"Crossref","is-referenced-by-count":34,"title":["Quantitative assessment of changes in hemodynamics of the internal carotid artery after bypass surgery for moyamoya disease"],"prefix":"10.3171","volume":"129","author":[{"given":"Fengping","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"},{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qian","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaavya","family":"Karunanithi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital;"},{"name":"State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1161\/STROKEAHA.115.008836","article-title":"Changes in wall shear stress of cerebral arteriovenous malformation feeder arteries after embolization and surgery","volume":"46","author":"Alaraj A","year":"2015","unstructured":"Alaraj A, Shakur SF, Amin-Hanjani S, Mostafa H, Khan S, Aletich VA, : Changes in wall shear stress of cerebral arteriovenous malformation feeder arteries after embolization and surgery. 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